Data Sheet 1_Unveiling the anti-inflammatory potential of olive leaf phenolic extracts in diabetes-related endothelial dysfunction.docx by Ilaria Cappellacci (12997431)

“…VCAM-1 protein expression and TNFα-induced monocyte adhesion were also significantly decreased following extract treatment. …”

Image 1_CD155 as a therapeutic target in alveolar echinococcosis: insights from an Echinococcus multilocularis infection mouse model.tif by Xue Zhang (166886)

“…</p>Results<p>CD155 expression in hepatocytes was significantly increased—approximately 2-fold compared to Sham controls—and predominantly localized near lesion sites. …”

DataSheet1_Sodium danshensu modulates skeletal muscle fiber type formation and metabolism by inhibiting pyruvate kinase M1.docx by Yunxia Zhang (30848)

“…Muscle mass, the percentage of slow oxidative fibers, succinic dehydrogenase activity, muscle endurance, glucose tolerance, and the expression of the MyHC1 and MyHC2a genes increased while MyHC2b expression, lactate dehydrogenase activity, and the percentage of glycolytic muscle fibers decreased in SDSS-treated mice. Mechanistically, SDSS bound to the pyruvate kinase PKM1 and significantly repressed its activity. …”

Data Sheet 14_Congrong Shujing Granules ameliorates mitochondrial associated membranes to against MPP+-induced neurological damage in the cellular model of Parkinson’s disease.pdf... by Chutian Zhang (10732350)

“…The serum effectively mitigated damage within the MAMs region and reduced both the mitochondrial-Ca²⁺ fluorescence intensity and the expression of the IP₃R-VDAC-MCU complex in MPP⁺-induced neuronal cells. Additionally, it significantly decreased the levels of ROS, the decline in MMP, and apoptosis rates in these cells.…”

Image 1_N1-methylnicotinamide promotes age-related cochlear damage via the overexpression of SIRT1.tif by Toru Miwa (8528715)

“…Auditory brainstem response (ABR) thresholds were significantly elevated, and distortion-product otoacoustic emissions (DPOAE) indicated outer hair cell dysfunction. …”

Table 8_Interactions between the intestinal microbiome and host genes in regulating vibriosis resistance in Cynoglossus semilaevis.xlsx by Weiwei Zheng (140828)

“…</p>Results<p>Obvious histopathological differences were observed between the resistant and susceptible groups in terms of inflammatory cells infiltration, and tissue dissociation of mucosal layer. 16S rRNA sequencing analysis indicated that Vibrio increased but Stenotrophomonas, Chryseobacterium, Delftia, and Salinivibrio decreased in the susceptible group. Compared to the control group, 1,986 differentially expressed genes (DEGs) were detected in the susceptible group, significantly more than the 310 DEGs found in the resistant group. …”

pone.0337200.t001 - by Razia Rashid Rahil (22772495)

“…Moreover, GW4869 (SMase inhibitor) and evogliptin significantly reduced SMase activity in sphingomyelin (SM)-induced VSMCs as compared to both P_i and SM only-treated groups. …”

Supplementary Material for: Bidirectional Impact of Varying Severity of Acute Kidney Injury on Calcium Oxalate Stone Formation by Yang Y. (3237684)

“…Transcriptomic analysis revealed that genes associated with inflammation and cell adhesion pathways were significantly upregulated after severe AKI, while genes related to energy metabolism pathways were significantly upregulated after mild AKI. …”

Table 6_Interactions between the intestinal microbiome and host genes in regulating vibriosis resistance in Cynoglossus semilaevis.xlsx by Weiwei Zheng (140828)

“…</p>Results<p>Obvious histopathological differences were observed between the resistant and susceptible groups in terms of inflammatory cells infiltration, and tissue dissociation of mucosal layer. 16S rRNA sequencing analysis indicated that Vibrio increased but Stenotrophomonas, Chryseobacterium, Delftia, and Salinivibrio decreased in the susceptible group. Compared to the control group, 1,986 differentially expressed genes (DEGs) were detected in the susceptible group, significantly more than the 310 DEGs found in the resistant group. …”

Table 7_Interactions between the intestinal microbiome and host genes in regulating vibriosis resistance in Cynoglossus semilaevis.xlsx by Weiwei Zheng (140828)

“…</p>Results<p>Obvious histopathological differences were observed between the resistant and susceptible groups in terms of inflammatory cells infiltration, and tissue dissociation of mucosal layer. 16S rRNA sequencing analysis indicated that Vibrio increased but Stenotrophomonas, Chryseobacterium, Delftia, and Salinivibrio decreased in the susceptible group. Compared to the control group, 1,986 differentially expressed genes (DEGs) were detected in the susceptible group, significantly more than the 310 DEGs found in the resistant group. …”

Table 1_Systematic pharmacology-based strategy to investigate the mechanism of beta-sitosterol for the treatment of rheumarthritis.docx by Xiaodong Wang (66801)

“…The experimental results showed that β-sitosterol could significantly inhibit the excessive proliferation of MH7A cells (p< 0.05). …”

Data Sheet 2_Congrong Shujing Granules ameliorates mitochondrial associated membranes to against MPP+-induced neurological damage in the cellular model of Parkinson’s disease.pdf by Chutian Zhang (10732350)

“…The serum effectively mitigated damage within the MAMs region and reduced both the mitochondrial-Ca²⁺ fluorescence intensity and the expression of the IP₃R-VDAC-MCU complex in MPP⁺-induced neuronal cells. Additionally, it significantly decreased the levels of ROS, the decline in MMP, and apoptosis rates in these cells.…”

Table_3_Effects of clear corneal incision location and morphology on corneal surgically induced astigmatism and higher-order aberrations after ICL V4c implantation.DOCX by Jun Wang (5906)

“…Anterior corneal SIA was significantly correlated to Dis-En and Dis-Ex in the superior CCI group. …”

Image_1_Effects of clear corneal incision location and morphology on corneal surgically induced astigmatism and higher-order aberrations after ICL V4c implantation.JPEG by Jun Wang (5906)

“…Anterior corneal SIA was significantly correlated to Dis-En and Dis-Ex in the superior CCI group. …”

Data Sheet 2_The global, regional, and national burden of colorectal cancer and its attributable risk factors in 204 countries and territories, 1990-2021: a systematic analysis for... by Shen Tian (4424170)

“…Key risk factors included behavioral and metabolic factors, among which a diet low in whole grains significantly increased CRC incidence.</p>Conclusion<p>From 1990 to 2021, the global CRC burden increased significantly, with notable variations across SDI regions. …”

Image 1_Effectiveness of Mindfulness and Qigong Training for Self-Healing in patients with Hwabyung and depressive disorder: a randomized controlled trial.tif by Seok-In Yoon (13879160)

“…</p>Results<p>MQT-SH significantly decreased Hwabyung, depression, anxiety, and anger while increasing subjective vitality, and the effectiveness of the intervention were maintained at a short-term follow-up of 6 weeks. …”

Table 2_Qinggan Yipi capsule ameliorates hepatic fibrosis in rats by down-regulating the TGF-β1/Smad2/3 signaling pathway and improving gut microbiota imbalance.docx by Wenjing Xue (2880686)

“…GO and KEGG analyses indicated that QgYp significantly affects TGF-β signaling pathway. In addition, the results of qPCR and Western blot analysis from both in vitro and in vivo experiments indicated that QgYp significantly downregulated the expression of proteins and mRNA associated with the TGF-β1/Smad2/3 pathway. …”

Data Sheet 12_Congrong Shujing Granules ameliorates mitochondrial associated membranes to against MPP+-induced neurological damage in the cellular model of Parkinson’s disease.zip... by Chutian Zhang (10732350)

“…The serum effectively mitigated damage within the MAMs region and reduced both the mitochondrial-Ca²⁺ fluorescence intensity and the expression of the IP₃R-VDAC-MCU complex in MPP⁺-induced neuronal cells. Additionally, it significantly decreased the levels of ROS, the decline in MMP, and apoptosis rates in these cells.…”

Data Sheet 2_Qinggan Yipi capsule ameliorates hepatic fibrosis in rats by down-regulating the TGF-β1/Smad2/3 signaling pathway and improving gut microbiota imbalance.pdf by Wenjing Xue (2880686)

“…GO and KEGG analyses indicated that QgYp significantly affects TGF-β signaling pathway. In addition, the results of qPCR and Western blot analysis from both in vitro and in vivo experiments indicated that QgYp significantly downregulated the expression of proteins and mRNA associated with the TGF-β1/Smad2/3 pathway. …”

Supplementary Material for: Does oXiris Matter? A Comparative Outcome Study in CRRT-Treated Septic ICU Patients by figshare admin karger (2628495)

“…Inflammatory markers (CRP, PCT) remained elevated in oXiris patients through day 5, while hemodynamic stabilization (lactate decline, norepinephrine reduction) was more pronounced. Platelet counts decreased in both groups without recovery. Conclusions: Our study demonstrated that patients with sepsis treated using the oXiris filter exhibited significantly higher ICU survival rates, despite higher mechanical ventilation duration and ICU length of stay. …”