Data Sheet 1_Hypothalamic FTO upregulates BDNF to promote GnRH expression through the PI3K/Akt pathway, leading to precocious puberty.pdf by Shaolian Zang (11987905)

“…</p>Results<p>Hypothalamic GnRH and FTO expression progressively increased whereas m6A methylation decreased during puberty. …”

Table 1_Hypothalamic FTO upregulates BDNF to promote GnRH expression through the PI3K/Akt pathway, leading to precocious puberty.docx by Shaolian Zang (11987905)

“…</p>Results<p>Hypothalamic GnRH and FTO expression progressively increased whereas m6A methylation decreased during puberty. …”

Image 3_Hypothalamic FTO upregulates BDNF to promote GnRH expression through the PI3K/Akt pathway, leading to precocious puberty.tif by Shaolian Zang (11987905)

“…</p>Results<p>Hypothalamic GnRH and FTO expression progressively increased whereas m6A methylation decreased during puberty. …”

Image 2_Hypothalamic FTO upregulates BDNF to promote GnRH expression through the PI3K/Akt pathway, leading to precocious puberty.tif by Shaolian Zang (11987905)

“…</p>Results<p>Hypothalamic GnRH and FTO expression progressively increased whereas m6A methylation decreased during puberty. …”

Image 1_Hypothalamic FTO upregulates BDNF to promote GnRH expression through the PI3K/Akt pathway, leading to precocious puberty.tif by Shaolian Zang (11987905)

“…</p>Results<p>Hypothalamic GnRH and FTO expression progressively increased whereas m6A methylation decreased during puberty. …”

3D culture raw data by Yaojun Luo (20296512)

“…Notably, N⁶-methyladenosine (m⁶A), the predominant internal modification on mRNAs in eukaryotes, was significantly decreased in 3D cultured eWAT preadipocytes at day 1 post-treatment with the MDI cocktail. …”

<i>Neisseria</i> species on the tonsillar surface predicts favorable clinical outcomes in patients with Immunoglobulin A nephropathy who underwent tonsillectomy by Ryosuke Sato (615801)

“…<p>An aberrant mucosal immune response against commensal bacteria in the tonsils is hypothesized to be one of the pathogenic mechanisms underlying immunoglobulin A nephropathy (IgAN). However, the bacteria involved in the pathogenesis of IgAN have not been fully elucidated. …”

Agreement between microscopy and qPCR analysis of MarBTN progression. by Rachael M. Giersch (22331947)

Detection of MarBTN-specific eDNA in tank water at late stages of MarBTN progression. by Rachael M. Giersch (22331947)

MarBTN-specific eDNA detection in each clam that was followed for MarBTN in hemolymph and eDNA. by Rachael M. Giersch (22331947)

Modeling the relationship between cancer level in hemolymph and MarBTN in tank eDNA. by Rachael M. Giersch (22331947)

Survival of soft-shell clams with MarBTN compared to control clams. by Rachael M. Giersch (22331947)

“…(<i>B</i>) Analysis of long-term non-progressing clams (n = 11, light red line), along with their respective paired controls (blue line), shows no difference in survival with maintained low-level infection. (C) A sub-analysis of low-positive clams in which MarBTN progressed and did not regress (n = 9, dark red line), with survival starting at the time the clam was detected with >10% cancer, compared with their paired control clams starting at the same date (blue line), shows a significant decrease in time-to death. “+” marks the dates at which two negative control animals were culled before natural death (these events were censored in the survival analysis).…”

Mod is required to maintain nucleolar architecture. by Amalia S. Parra (4173004)

Development of <i>Drosophila</i> Neuroblasts (NB). by Amalia S. Parra (4173004)

RNA targets of Mod identified by RiP-Seq. by Amalia S. Parra (4173004)

“…Mod is expressed in larval brains and its loss leads to a significant decrease in the number of central brain NBs. …”

Data for Fig 1. by Rachael M. Giersch (22331947)

“…We observed variable outcomes, with about half of clams (9/21) progressing to high levels of cancer and death, about half exhibiting long-term non-progression (11/21), and a single animal showing regression of cancer. We also observe a significant decrease in survival in animals that progress to >10% cancer in their hemolymph, while we see no effect on survival in clams with BTN that are long-term non-progressors. …”

Changepoint analysis in comparison of MarBTN-specific eDNA and cancer in hemolymph. by Rachael M. Giersch (22331947)

S1 Data - by Richard Junior Zapata Dongo (17912565)

“…This interaction was further supported by a significant decrease of ALK phosphorylation in single and combination treatment with 300nM ABT-199. …”

Loss of Mod does not affect NB asymmetric cell division. by Amalia S. Parra (4173004)

Negative (Prednisone) and basal (ATP) control compounds binding to ALK protein. by Richard Junior Zapata Dongo (17912565)