Showing 1 - 20 results of 86,473 for search '(( significantly ((nn decrease) OR (_ decrease)) ) OR ( significant hits increased ))', query time: 1.30s Refine Results
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    Validation of primary screen hits reveals compounds that recapitulate increased spheroid size (swell) or decreased MUC5AC in the lumen. by Pranjali Beri (14945400)

    Published 2023
    “…Compounds that appeared to cause toxicity were identified by observing a significant decrease in spheroid counts in the swell readout or a significant decrease in the total nuclear intensity of the MUC5AC ratio readout. …”
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    Spheroid size changes due to primary mucus reduction hits and mucus changes due to primary swell hits. by Pranjali Beri (14945400)

    Published 2023
    “…Compounds 56 (1μM), 85 (10μM), and 294 (1 and 10μM) significantly increased MUC5AC ratio compared to DMSO + CSE 3% control and were therefore filtered out of swell hit selection. …”
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