Discovery of an Orally Active PDE1 Inhibitor for Disease-Modifying Treatment of Postmenopausal Osteoporosis via Dual Anabolic-Antiresorptive Mechanisms by Farman M. Abbasi (22318766)

“…In ovariectomized mice, <b>5cc</b> administration (5 mg/kg) improved the trabecular microarchitecture, bone mineral density, and strength, at levels comparable to teriparatide, while significantly reducing bone resorption markers. With 13.57% oral bioavailability and selectivity for PDE1A1 (32% inhibition at 500 nM), <b>5cc</b> offers an innovative therapeutic candidate for PMO with a dual anabolic-antiresorptive profile and oral efficacy, warranting further clinical development.…”

Discovery of an Orally Active PDE1 Inhibitor for Disease-Modifying Treatment of Postmenopausal Osteoporosis via Dual Anabolic-Antiresorptive Mechanisms by Farman M. Abbasi (22318766)

“…In ovariectomized mice, <b>5cc</b> administration (5 mg/kg) improved the trabecular microarchitecture, bone mineral density, and strength, at levels comparable to teriparatide, while significantly reducing bone resorption markers. With 13.57% oral bioavailability and selectivity for PDE1A1 (32% inhibition at 500 nM), <b>5cc</b> offers an innovative therapeutic candidate for PMO with a dual anabolic-antiresorptive profile and oral efficacy, warranting further clinical development.…”

Discovery of an Orally Active PDE1 Inhibitor for Disease-Modifying Treatment of Postmenopausal Osteoporosis via Dual Anabolic-Antiresorptive Mechanisms by Farman M. Abbasi (22318766)

“…In ovariectomized mice, <b>5cc</b> administration (5 mg/kg) improved the trabecular microarchitecture, bone mineral density, and strength, at levels comparable to teriparatide, while significantly reducing bone resorption markers. With 13.57% oral bioavailability and selectivity for PDE1A1 (32% inhibition at 500 nM), <b>5cc</b> offers an innovative therapeutic candidate for PMO with a dual anabolic-antiresorptive profile and oral efficacy, warranting further clinical development.…”

Effect of parasitism and PDV injection on triglyceride concentration and lipid metabolism-related gene expression in FAW larvae. by Xian Li (201841)

Box plots to show various parameters of GI motility in the anterior, mid, and posterior intestine of ED, HFD and SDG larvae compared with the SD controls, at 7 dpf. by Jessica C. M. Hui (20370522)

Key CHWs’ performance indicators by focus and time period. by Nicole Michelén Ströfer (19269154)

Box plots to show various parameters of GI motility in the anterior, mid, and posterior intestine of ED, HFD and SDG larvae compared with the SD controls, at 7 dpf. by Jessica C. M. Hui (20370522)

NMP inhibits the incorporation of ¹⁴C-palmitic acid into glycopeptidolipids, phosphatidylethanolamine and cardiolipin in <i>M</i>. <i>abscessus</i>. by Timilehin Faboro (20175963)

Box plots to show various parameters of the rectal waves ED, HFD and SDG larvae compared with the SD controls, at 7 dpf. by Jessica C. M. Hui (20370522)

ASFV-ΔI7L induces higher immune responses than does ASFV-WT in pigs. by Meilin Li (1832905)

List of captured wild pollinator species. by Carmelo Gómez-Martínez (9384385)

“…Overall pollinator abundance was slightly higher in ecological than conventional orchards, but the difference was not significant. High male-to-female ratio enhanced overall pollinator abundance and shaped pollinator composition, by increasing hoverfly abundance and decreasing wasp and fly abundance. …”

Map of the 20 study orchards. by Carmelo Gómez-Martínez (9384385)

“…Overall pollinator abundance was slightly higher in ecological than conventional orchards, but the difference was not significant. High male-to-female ratio enhanced overall pollinator abundance and shaped pollinator composition, by increasing hoverfly abundance and decreasing wasp and fly abundance. …”

Pictures of carob tree flowers and orchard. by Carmelo Gómez-Martínez (9384385)

“…Overall pollinator abundance was slightly higher in ecological than conventional orchards, but the difference was not significant. High male-to-female ratio enhanced overall pollinator abundance and shaped pollinator composition, by increasing hoverfly abundance and decreasing wasp and fly abundance. …”

Differential expression profiling in the ASFV-ΔI7L-infected primary porcine alveolar macrophages (PAMs) by RNA sequencing analysis. by Meilin Li (1832905)

Effect of parasitism and PDV injection on lipid droplet size in the fat body of FAW larvae. by Xian Li (201841)

Role of YAP/TAZ in FAT1-regulated HNSCC growth. by Rui Li (4631)

pI7L suppresses the IFN-γ-triggered JAK-STAT signaling pathway. by Meilin Li (1832905)

The <i>I7L</i> gene is involved in ASFV pathogenicity in pigs. by Meilin Li (1832905)

Measurements of body mass index (BMI) and adipose deposits. by Jessica C. M. Hui (20370522)

Loss of FAT1 expression results in increased YAP/TAZ protein levels. by Rui Li (4631)