Image 3_Unraveling impact and potential mechanisms of baseline pain on efficacy of immunotherapy in lung cancer patients: a retrospective and bioinformatic analysis.jpg by Zexin Zhang (7507979)

“…ELISA assay results indicated that the level of CXCL12 significantly decreased compared to baseline after pain was relieved.…”

Tanshinone I as a novel therapeutic agent targeting von Willebrand factor-binding protein to mitigate <i>Staphylococcus aureus</i> pathogenicity by Shiyu Zhou (457967)

“…This study underscores the potential of tanshinone I as a therapeutic agent against <i>S. aureus</i> infections, offering a novel strategy to combat bacterial infections while decreasing the critical issue of antibiotic resistance.…”

Supplementary Material for: Global, regional, and national burden of motor neuron disease: a systematic analysis of prevalence, incidence, deaths, and DALYs with projections to 203... by figshare admin karger (2628495)

“…Results: From 1990 to 2021, the global number of MND cases, deaths, and DALYs increased significantly, while the age - standardized prevalence and incidence rates decreased. …”

Table 1_Effects of biochar on phosphorus fraction, phosphatase activity, and phosphorus-solubilizing bacterial abundance: a phosphorus-depleted biochar design.docx by Hongyi Qin (5943515)

“…Acid phosphatase activity was inhibited by PDB in upland soils (a peach orchard, a tea plantation, and a vegetable field). phoD-based sequencing indicated an increased relative abundance of dominant PSB genera in upland soils but a decreased abundance in paddy soils under PDB treatment. …”

Data Sheet 1_The relationship between hearing loss and frailty in older adults at risk of cognitive decline: a cross-sectional study.pdf by Rong Tian (397491)

“…Objectives<p>To investigate the association between hearing loss and frailty among a group of older community volunteers with mild cognitive impairment.…”

Table 1_Understanding the biochemical impact of leukoreduction on canine pRBC storage: a focus on reactive oxygen species and storage lesions.docx by Sun Woo Shin (22183162)

“…<p>Transfusion therapy is vital for both humans and animals, though it poses significant risks, including the development of storage lesions in packed red blood cells (pRBCs). …”

Table 2_Understanding the biochemical impact of leukoreduction on canine pRBC storage: a focus on reactive oxygen species and storage lesions.xlsx by Sun Woo Shin (22183162)

“…<p>Transfusion therapy is vital for both humans and animals, though it poses significant risks, including the development of storage lesions in packed red blood cells (pRBCs). …”

Table 1_Dupilumab relieves pruritus both in uremic pruritus and in atopic dermatitis with chronic kidney disease: a retrospective real-world study.docx by Qian Wang (32718)

“…</p>Results<p>After dupilumab treatment, the PP-NRS and 5D-IS scores of 12 AD patients with CKD and 10 UP patients were significantly decreased. The percentages of UP patients who achieved PP-NRS ≥ 4-point improvement and 5D-IS ≤ 10-point at week 4, 12, and 16 did not significantly differ from those of AD patients with CKD (p > 0.05). …”

Table 1_Association between platelet count and 30-day in-hospital mortality among intensive care unit patients with sepsis: a multicenter retrospective cohort study.docx by Jun Wang (5906)

“…Below this threshold, each 10 × 10⁹/L increase in platelet count was associated with a 6% decrease in mortality risk (adjusted OR 0.94, 95% CI 0.93–0.95, p < 0.0001), while above it, each 10 × 10⁹/L increase was associated with a 1% increase in mortality risk (adjusted OR 1.01, 95% CI 1.00–1.01, p = 0.0153).…”

<b>Identification and Validation of LOXL2 as a Prognostic Biomarker and Therapeutic Target in Lung Adenocarcinoma through Multi-Omics and Functional Analysis</b> by Ge Qiao (21802511)

“…A Cox proportional hazards model was employed to evaluate the prognostic significance and survival impact of these genes. …”

Image 1_Anlotinib combined with tislelizumab in the treatment of primary small cell neuroendocrine carcinoma of the prostate: a case report and literature review.jpeg by Xin Fei (20466992)

“…The patient was then administered a combination of anlotinib and tislelizumab. After treatment, the patient’s symptoms were controlled, tumor marker levels decreased, and imaging showed significant improvement. …”

Supplementary Material for: Delayed Onset of Central Serous Chorioretinopathy (CSCR) following corticosteroid treatment for Giant Cell Arteritis (GCA): A Case Report by figshare admin karger (2628495)

“…Case Presentation: We present a case of a 71-year-old man who developed CSCR following six months of corticosteroid treatment for GCA. …”

Table 1_Loneliness and mental burden among German medical students during the fading COVID-19 pandemic: a mixed-methods approach.docx by Marvik Leich (20930363)

“…Binary regression models indicated a shift in loneliness risk factors: in winter 2021/22, being single, higher self-perceived stress levels, and decreased study motivation were associated with increased loneliness. …”

Table 1_CD3zeta-mediated modulation of TCR signaling: a novel strategy for neuroprotection in retinal ganglion cell degeneration.docx by Kexin Xu (757891)

“…The neuroprotective effect of CD3ζ knockdown was accompanied by the restoration of MAPK signaling, specifically the phosphorylation of ERK and p38, and attenuation of NF-κB activation, indicated by decreased p65 phosphorylation. Furthermore, CD3ζ knockdown reduced the levels of proinflammatory mediators (IL-1β, TNF-α, and MMP-9) and increased that of the anti-inflammatory cytokine IL-10, creating a retinal microenvironment conducive to neuroprotection.…”

Data Sheet 1_Predict and prevent microvascular complications of type 2 diabetes: a cross-sectional and longitudinal study in Chinese communities.docx by Zhaoxiang Liu (9019424)

“…The risk of DKD increased more rapidly as HbA1c exceeded 7.5% and decreased as blood pressure was maintained below 120/70 mmHg. …”

Data Sheet 1_Evaluation of Lactiplantibacillus plantarum CRS 33 to therapeutic effects on a murine model of Escherichia coli-induced endometritis.zip by Mingchao Liu (1390666)

“…Introduction<p>Bovine endometritis is a common postpartum uterine disease in dairy cows that is traditionally treated with antibiotics. …”

Data Sheet 1_Identification of key genes and immune infiltration mechanisms in limb ischemia-reperfusion injury: a bioinformatics and experimental study.docx by Qiyun Shi (5531150)

“…</p>Results<p>From 169 differentially expressed genes (116 upregulated, 53 downregulated), machine learning identified four key genes (WNT5A, PLCG, ITPR1, CAMK2A), significantly upregulated in experimental limb IRI (P<0.01). …”

Table 2_Interaction between dietary selenium intake and age on severe headache or migraine in the United States: a population-based study.docx by Xinping Yu (555177)

“…The OR of developing migraine was 0.97 (95% CI: 0.94–0.98) in individuals with selenium intake ≥101.9 ug/day in adults with 20–50 years.</p>Conclusion<p>A higher dietary selenium intake is significantly associated with a decreased prevalence of migraine, and age can modify the association between them. …”

Data Sheet 1_Metastatic organ count stratifies survival in immunotherapy-treated metastatic colorectal cancer: a retrospective cohort study.docx by Hai-Yan Fu (1586935)

“…</p>Conclusions<p>Increased metastatic organ count in patients with mCRC was associated with decreased immunotherapy ORR and worse prognosis, with a particularly pronounced effect observed in patients with lung metastasis.…”

Image 1_CD3zeta-mediated modulation of TCR signaling: a novel strategy for neuroprotection in retinal ganglion cell degeneration.jpeg by Kexin Xu (757891)

“…The neuroprotective effect of CD3ζ knockdown was accompanied by the restoration of MAPK signaling, specifically the phosphorylation of ERK and p38, and attenuation of NF-κB activation, indicated by decreased p65 phosphorylation. Furthermore, CD3ζ knockdown reduced the levels of proinflammatory mediators (IL-1β, TNF-α, and MMP-9) and increased that of the anti-inflammatory cytokine IL-10, creating a retinal microenvironment conducive to neuroprotection.…”