Combating Chemoresistance in Breast Cancer: Exploring Tumor Microenvironment, Combination Therapies, and Drug Repurposing Strategies حسب Shazia Sofi (17764488)

"…Chemoresistance in cancer can arise from a variety of molecular mechanisms, including active drug expulsion (drug efflux), decreased drug uptake, enhanced DNA repair mechanisms, the ability of cancer cells to evade programmed cell death (apoptosis), the diversity in the population of cancer cells within a tumor (tumor heterogeneity), and significant alterations in the tumor microenvironment (TME), where interactions between cancer cells, cancer-associated fibroblasts, immune cells, and the extracellular matrix contribute to a supportive environment that allows tumors to survive treatment and escape therapy. …"

Table 1_Psychometric analysis of the social connectedness instrument.docx حسب Brian Kelley (1271004)

"…Introduction<p>Social connectedness is decreasing, especially among young adults, which poses a significant public mental and physical health threat globally. …"

Supplementary file 1_Monitoring the dual-season hydrological dynamics of the Pong reservoir in Himachal Pradesh, India.docx حسب Rajesh Sarda (13162317)

"…The study employed a spatial linear trend modelling approach to identify trends in relative water depth, revealing a decreasing trend and a quantifiable reduction in the reservoir’s depth for both seasons. …"

Supplemental Tables S1-S5 حسب Kevin Gries (21956942)

"…These findings indicate that a single day of reduced physical activity can elicit modest but significant changes in the metabolic and transcriptomic exercise response. …"

Unveiling the molecular legacy of transient insulin resistance: Implications for hepatic metabolic adaptability (Sup Tables). Berthier et al. J. Hepatol. 2025 حسب Alexandre Berthier (16876311)

"…</p><h3>Results</h3><p dir="ltr">Our study shows that temporarily blocking the insulin receptor in young mice leads to later-life liver issues by hindering PPARα-mediated adaptation to a high-fat diet. This is linked to decreased histone active marks at PPARα sites and reduced endogenous PPARα ligands. …"

Supplementary file 1_Collaborative optimal operation control of HVAC systems based on multi-agent.docx حسب Chen Fu (165356)

"…<p>The HVAC system of public buildings, as a thermostatically controlled load, accounting for a relatively significant proportion of building energy consumption. …"

Effects of incubation temperature and sex on local and systemic immune parameters in broiler chickens حسب K. Papanikolaou (22476654)

"…The 36.5°C treatment showed a potential improvement in immune function by increasing the opsonisation potential of blood serum indicating a potential beneficial effect of the lowered temperature.…"

Alcohol perceptions and driving decisions among adolescents: Exploring the role of peer and parental influences in Virginia حسب Asmaa Namoos (21304297)

"…Though parent distracted driving positively influenced adolescent driving behavior, this effect was not statistically significant (coefficient = 0.008, <i>P</i> = .320).</p> <p>The findings indicate a significant reduction in risky behaviors such as drinking and driving and an increase in seat belt use among adolescents. …"

Table 1_CyTOF reveals platelet subtype changes predicting the efficacy of combined immunotherapy and targeted therapy in liver cancer.docx حسب Wenjing Wang (181404)

"…However, some patients still exhibit poor therapeutic outcomes. Platelets, as a critical component of blood, play a significant role in liver cancer progression by influencing angiogenesis and the tumor immune microenvironment.…"

GPCR kinase, <i>Ppa</i>-GRK-2 is required for light avoidance. حسب Kenichi Nakayama (2354653)

"…<i>Ppa-grk-2</i> mutants had decreased light avoidance. One-way ANOVA, Dunnett’s multiple comparison tests, compared with wild type. n.s = not significant, ***<i>P</i> < 0.001, ****<i>P</i> < 0.0001.…"

PVD neurons show reduced lysosome function during aging and in the <i>hlh-30</i> mutant. حسب Ruiling Zhong (22339779)

"…<p><b>(A–D)</b> A fluorescent reporter for luminal acidity of neuronal lysosomal compartments shows that acidity decreases with aging and in the <i><i>hlh-30</i></i> mutant. …"

Table 4_Scalability of spheroid-derived small extracellular vesicles production in stirred systems.xlsx حسب Thibaud Dauphin (21196820)

"…Implementing upstream processes in a chemically defined media in stirred-tank bioreactors (STBr) is mandatory to closely control the cell environment, and to scale-up production, but it remains a significant challenge for anchorage-dependent cells.…"

Table 2_Scalability of spheroid-derived small extracellular vesicles production in stirred systems.xlsx حسب Thibaud Dauphin (21196820)

"…Implementing upstream processes in a chemically defined media in stirred-tank bioreactors (STBr) is mandatory to closely control the cell environment, and to scale-up production, but it remains a significant challenge for anchorage-dependent cells.…"

Table 1_Scalability of spheroid-derived small extracellular vesicles production in stirred systems.docx حسب Thibaud Dauphin (21196820)

"…Implementing upstream processes in a chemically defined media in stirred-tank bioreactors (STBr) is mandatory to closely control the cell environment, and to scale-up production, but it remains a significant challenge for anchorage-dependent cells.…"

Table 3_Scalability of spheroid-derived small extracellular vesicles production in stirred systems.xlsx حسب Thibaud Dauphin (21196820)

"…Implementing upstream processes in a chemically defined media in stirred-tank bioreactors (STBr) is mandatory to closely control the cell environment, and to scale-up production, but it remains a significant challenge for anchorage-dependent cells.…"

Yeast strains used in this study. حسب Hilary T. Brewis (11798006)

"…Furthermore, as H2A.Z mutants only display significant growth defects in genotoxic stress conditions, a more substantive role for H2A.Z in gene expression may only be uncovered after exposure to cellular stress. …"

Figure 5 from KDM6 Demethylases Contribute to EWSR1::FLI1-Driven Oncogenic Reprogramming in Ewing Sarcoma حسب Elisabet Figuerola-Bou (22618659)

"…<p>KDM6A KO decreases Ewing sarcoma tumor growth. <b>A,</b> Colony formation assay of KDM6A KO cells (sgRNA#1 and sgRNA#2) compared with parental cells and sgCTRL in A-673. …"

Supplementary Tables 1-7 from Androgen Receptor Inhibition Increases MHC Class I Expression and Improves Immune Response in Prostate Cancer حسب Lisa N. Chesner (19677087)

"…<p>Table S1: List of top 20 significant (p< 0.05) genes from a whole-genome CRISPRi FACS-based screen which increased or decreased MHC Class I expression upon knockdown. …"

Supplementary Tables 1-7 from Androgen Receptor Inhibition Increases MHC Class I Expression and Improves Immune Response in Prostate Cancer حسب Lisa N. Chesner (19677087)

"…<p>Table S1: List of top 20 significant (p< 0.05) genes from a whole-genome CRISPRi FACS-based screen which increased or decreased MHC Class I expression upon knockdown. …"

Effects of liposomal bupivacaine (LB) and provider experience with LB on service utilization, clinical outcomes, and Medicare expenditures among fee-for-service (FFS) beneficiaries حسب Sarmistha Pal (13348959)

"…</p> <p></p><p>Liposomal bupivacaine (LB) represents a significant advancement in postoperative pain management, with studies demonstrating its ability to reduce opioid consumption and improve recovery outcomes. …"