Table 4_The dysbiosis of gut microbiota and dysregulation of metabolites in IgA nephropathy and membranous nephropathy.xlsx by Lei Zhang (38117)

“…Notably, both IgAN and MN patients showed a decrease in the abundance of certain specific microbial taxa. …”

Data Sheet 1_Cepharanthine may inhibit the proliferation of prostate cells by blocking the EGFR/PI3K/AKT signaling pathway: comprehensive network analysis, molecular docking, and e... by Yin Huang (179237)

“…Celigo counting revealed a significant decrease in both cell lines after 24–96 h of CEP treatment. …”

Table1_Safety evaluation of medroxyprogesterone acetate: a pharmacovigilance analysis using FDA adverse event reporting system data.DOCX by Luyang Su (20411552)

“…Unforeseen significant AEs such as unintended pregnancy (n = 623; ROR, 6.65; ROR025, 6.1; χ², 2,482.38; PRR, 6.41; EBGM, 5.69; EBGM05, 5.29), bone pain (n = 35; ROR, 13.78; ROR025, 9.4; χ², 311.2; PRR, 13.75; EBGM, 10.59; EBGM05, 7.69), gait disturbance (n = 34; ROR, 2.82; ROR025, 1.99; χ², 37.31; PRR, 2.88; EBGM, 2.7; EBGM05, 2.02), dental caries (n = 15; ROR, 23.16; ROR025, 12.32; χ², 204.26; PRR, 23.14; EBGM, 15.23; EBGM05, 8.98), decrease in blood pressure (n = 15; ROR, 3.88; ROR025, 2.29; χ², 29.35; PRR, 3.88; EBGM, 3.63; EBGM05, 2.33), and osteonecrosis (n = 9; ROR, 23.44; ROR025, 10.36; χ², 123.67; PRR, 23.43; EBGM, 15.35; EBGM05, 7.75) were identified as AEs that were not previously outlined in the prescribing information of the medication.…”

Data_Sheet_2_Long-Term Overconsumption of Sugar Starting at Adolescence Produces Persistent Hyperactivity and Neurocognitive Deficits in Adulthood.PDF by Kate Beecher (6688340)

“…The deficits in hippocampal-dependent learning and memory were accompanied by altered hippocampal neurogenesis, with an overall decrease in the proliferation and differentiation of newborn neurons within the dentate gyrus. …”

Bioassay and NMR-HSQC-Guided Isolation and Identification of Phthalide Dimers with Anti-Inflammatory Activity from the Rhizomes of Angelica sinensis by Hongyan Wen (9226895)

“…Among them, compound <b>9</b> showed a remarkable inhibitory activity with IC₅₀ values of 425 nM and could significantly decrease IL-1β and IL-6 transcription levels. …”

Discovering a novel dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) inhibitor and its impact on tau phosphorylation and amyloid-β formation by Huang-Ju Tu (630766)

“…Although the development of DYRK1A inhibitors has significantly advanced in recent years, the selectivity of these drugs remains a critical challenge, potentially impeding further progress. …”

Data_Sheet_1_Long-Term Overconsumption of Sugar Starting at Adolescence Produces Persistent Hyperactivity and Neurocognitive Deficits in Adulthood.PDF by Kate Beecher (6688340)

“…The deficits in hippocampal-dependent learning and memory were accompanied by altered hippocampal neurogenesis, with an overall decrease in the proliferation and differentiation of newborn neurons within the dentate gyrus. …”

Bioassay and NMR-HSQC-Guided Isolation and Identification of Phthalide Dimers with Anti-Inflammatory Activity from the Rhizomes of Angelica sinensis by Hongyan Wen (9226895)

“…Among them, compound <b>9</b> showed a remarkable inhibitory activity with IC₅₀ values of 425 nM and could significantly decrease IL-1β and IL-6 transcription levels. …”

Effects of Nitro-Substitution on the Spectroscopic and Self-Assembly Properties of BODIPY Dyes by Caroline Gwaro (21012411)

“…In a polar organic solvent, nitro-substitution tends to quench the characteristic fluorescence of BODIPYs, while in a nonpolar solvent, significantly higher absolute fluorescence quantum yields are observed. …”

Presentation_1_Src Inhibition Attenuates Neuroinflammation and Protects Dopaminergic Neurons in Parkinson’s Disease Models.PDF by Hanyu Yang (8374881)

“…The results showed that inhibition of Src could significantly relieve microgliosis and decrease levels of inflammatory factors. …”

Predicting the potential distribution of <i>Arisaema heterophyllum</i> in China under current and future climate change based on ArcGIS and MaxEnt model by Jing Xu (15337)

“…<p>Climate change significantly affects the distribution of medicinal plants, necessitating accurate models to predict future shifts in their habitats. …”

OMT by Jingmin Ou (19669426)

“…<p dir="ltr">In this study, we performed a series of experiments to investigate the effects of oxymatrine (OMT) on hemangioma cells and its mechanisms. OMT was found to significantly increase the apoptosis rate of endothelial cells (ECs) treated with oxidised low-density lipoprotein (ox-LDL), as measured by caspase-3 activity assay and flow cytometry. qRT-PCR results showed that OMT treatment decreased the expression of miR-199a-5p in ECs.Transfection of miR-199a-5p mimics enhanced the apoptotic effect, whereas miR-199a-5p inhibitors attenuated apoptosis, suggesting that miR-199a-5p has a key regulatory role in EC apoptosis. …”

Data Sheet 1_A ROS-responsive, aptamer-targeted graphene oxide nanocomposite for site-specific glutathione release in cerebral ischemia-reperfusion injury.docx by Meiying Li (6051287)

“…In vitro, GO@GSH-FA significantly restored viability in oxygen-glucose-deprived SH-SY5Y cells (from 31% up to near control levels), reduced inflammatory cytokines, and lowered intracellular ROS. …”

DataSheet1_FOXO1-mediated autophagy regulation by miR-223 in sepsis-induced immunosuppression.ZIP by Guoan Xiang (383282)

“…</p>Results<p>We found that when the expression of miR-223 increased, FOXO1 expression decreased and autophagy decreased; whereas, when FOXO1 expression was inhibited, autophagy decreased significantly in different cell models after LPS induction.…”

Data from "A Historical Misstep: Niche Shift to Specialisation Is Pushing Insular Ginger Towards an Evolutionary Dead End" by Min-Wei Chai (15899033)

“…<i>Z. shuanglongense</i>, as the specialist, despite an initial increase during the Last Glacial Maximum (~22 Kya), has been subjected to a long-term decrease in effective population size (<i>Ne</i>), while <i>Z. pleiostachyum</i> is on the contrary increasing, leading to a significantly larger current <i>Ne</i>. …”

Data Sheet 1_Causal relationship between inflammatory bowel disease and sex: a Mendelian randomization study.pdf by Kaiwen Wang (838527)

“…</p>Results<p>There was no causal relationship between sex hormones and IBD in women (P > 0.05), and there was a causal and positive correlation between SHBG and testosterone and IBD in men.The OR for SHBG was 1.22 (95% CI: 1.09-1.37, P = 0.0004), and for testosterone was 1.20 (95% CI: 1.04-1.39, P = 0.0145).IBD did not significantly interact with female sex hormones but resulted in a decrease in SHBG (OR = 1.02, 95% CI: 1.00-1.04, P = 0.0195) and testosterone (OR = 1.01, 95% CI: 1.00 -1.02, P = 0.0200) in men.…”

A rapid behavioral toxicity test using common periwinkle <i>Littorina littorea</i> (Gastropoda: Littorinidae) by Bjørn Henrik Hansen (1636042)

“…The exposure resulted in a concentration-dependent decrease in active suction, with snails retracting into their shells, which significantly reduced their oxygen consumption, indicating avoidance behavior. …”

Data Sheet 1_Assessment of heat-killed E. coli expressing Chikungunya virus E2 protein as a candidate vaccine for dual protection against Chikungunya virus and E. coli.docx by Surajit Patra (18400578)

“…Similarly, the vaccine formulation also elicited a significantly higher IgG immune response against E. coli. …”

Table3_Multi-omics analysis provides insights into the mechanism underlying fruit color formation in Capsicum.docx by Zhao Song (7135202)

“…Additionally, missense mutation of LCYB2 is likely to lead to a decrease in β-carotene content in immature CSJ009 fruits, whereas CCS may directly catalyze the conversion of lycopene to β-carotene in mature fruits. …”

DataSheet2_FOXO1-mediated autophagy regulation by miR-223 in sepsis-induced immunosuppression.ZIP by Guoan Xiang (383282)

“…</p>Results<p>We found that when the expression of miR-223 increased, FOXO1 expression decreased and autophagy decreased; whereas, when FOXO1 expression was inhibited, autophagy decreased significantly in different cell models after LPS induction.…”