Search alternatives:
treatment increases » greater increases (Expand Search)
significant i » significant _ (Expand Search), significant anti (Expand Search), significant gap (Expand Search)
nn decrease » _ decrease (Expand Search), a decrease (Expand Search), mean decrease (Expand Search)
i decrease » _ decrease (Expand Search), a decrease (Expand Search), _ decreased (Expand Search)
treatment increases » greater increases (Expand Search)
significant i » significant _ (Expand Search), significant anti (Expand Search), significant gap (Expand Search)
nn decrease » _ decrease (Expand Search), a decrease (Expand Search), mean decrease (Expand Search)
i decrease » _ decrease (Expand Search), a decrease (Expand Search), _ decreased (Expand Search)
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Oxidative Nickel-Catalyzed <i>ortho</i>-C–H Amination of (Iso)quinolines with Alicyclic Amines Directed by a Sacrificial <i>N</i>‑Oxide Group
Published 2024“…Transition metal (TM)-catalyzed direct amination of C–H bonds on free or fused pyridine (Py) rings with free amines still remains scarce because amines and the Py ring tend to adopt a nonproductive N-bound coordination with many TMs, leading to a significant decrease of catalytic reactivity. We herein disclose a nickel-catalyzed and a sacrificial <i>N</i>-oxide group directed oxidative coupling of (iso)quinolyl C–H bonds and alicyclic amines, which furnishes bioimportant amino(iso)quinolines efficiently and selectively in a single step. …”
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