Data Sheet 1_Cannabinoid receptor 2 selective agonist ameliorates adjuvant-induced arthritis by modulating the balance between Treg and Th17 cells.docx by Na Tian (296333)

“…Western blot analysis indicated that HU-308 modulated immune balance through the JAK/STAT5 and TGF-β/SMAD signaling pathways, increasing Foxp3 and TGF-β expression.</p>Conclusion<p>HU-308 demonstrates significant anti-inflammatory effects in AIA by restoring Th17/Treg balance and reducing joint damage. …”

Supplementary file 1_Responses of fish population structure to barrage re-opening in an estuarine ecosystem.docx by Jeong-Soo Gim (18058588)

“…The Nakdong River Estuary (NRE), South Korea, provides a unique opportunity to assess the effects of temporary barrage re-opening on fish population structure.…”

Image1_Oleic acid attenuates asthma pathogenesis via Th1/Th2 immune cell modulation, TLR3/4-NF-κB-related inflammation suppression, and intrinsic apoptotic pathway induction.tif by Soon-Young Lee (4721136)

“…The incidence is expected to increase as the average life expectancy increases, highlighting asthma as a significant health challenge in an aging society. …”

<i>mig-21</i> sensitizes adult DTCs to polarizing signals. by Xin Li (51274)

“…However, migration cessation is not rescued; a significant increase in “overmigration” defects is observed between marked control (n=4/57) and <i>mig-21(u787)</i> on <i>vab-3</i> RNAi (n=17/65), p < 0.05. …”

Data Sheet 1_Global burden of disease among adolescents and young adults with drug use disorders, 1990–2021: based on GBD 2021.doc by Ming Wang (172316)

“…Additionally, gender plays a significant role in the distribution of this burden, with males experiencing a higher burden than females. …”

Table 2_The global burden of pediatric infective endocarditis (5–14 years): epidemiological patterns from 1990 to 2021 and projected trajectories.pdf by Ying Xiao (6517)

“…</p>Results<p>Globally, the incidence of pediatric IE declined by 27.6% (95% UI, −30.9% to −24.9%) and mortality by 21.4% (95% UI, −35.2% to −0.8%) between 1990 and 2021, with an estimated annual percentage change (EAPC) of −1.37% (95% CI, −1.49% to −1.24%) and −0.64% (95% CI, −0.75% to −0.54%), respectively. DALYs decreased by 19.2% (95% UI, −33.2% to 1.9%). Marked disparities persisted, with high-SDI regions, notably China, achieving the greatest reductions in burden, while sub-Saharan Africa and Eastern Europe exhibited stagnant or increasing rates. …”

Data Sheet 1_Impact of artificial intelligence on electronic health record-related burnouts among healthcare professionals: systematic review.pdf by Berna Sarraf (21651629)

“…Nevertheless, EHR-related workload has been considered as a significant contributor to healthcare professionals’ burnout, a syndrome associated with emotional exhaustion, depersonalization, and reduced personal accomplishment. …”

Table 1_The global burden of pediatric infective endocarditis (5–14 years): epidemiological patterns from 1990 to 2021 and projected trajectories.pdf by Ying Xiao (6517)

“…</p>Results<p>Globally, the incidence of pediatric IE declined by 27.6% (95% UI, −30.9% to −24.9%) and mortality by 21.4% (95% UI, −35.2% to −0.8%) between 1990 and 2021, with an estimated annual percentage change (EAPC) of −1.37% (95% CI, −1.49% to −1.24%) and −0.64% (95% CI, −0.75% to −0.54%), respectively. DALYs decreased by 19.2% (95% UI, −33.2% to 1.9%). Marked disparities persisted, with high-SDI regions, notably China, achieving the greatest reductions in burden, while sub-Saharan Africa and Eastern Europe exhibited stagnant or increasing rates. …”

Table 3_The global burden of pediatric infective endocarditis (5–14 years): epidemiological patterns from 1990 to 2021 and projected trajectories.pdf by Ying Xiao (6517)

“…</p>Results<p>Globally, the incidence of pediatric IE declined by 27.6% (95% UI, −30.9% to −24.9%) and mortality by 21.4% (95% UI, −35.2% to −0.8%) between 1990 and 2021, with an estimated annual percentage change (EAPC) of −1.37% (95% CI, −1.49% to −1.24%) and −0.64% (95% CI, −0.75% to −0.54%), respectively. DALYs decreased by 19.2% (95% UI, −33.2% to 1.9%). Marked disparities persisted, with high-SDI regions, notably China, achieving the greatest reductions in burden, while sub-Saharan Africa and Eastern Europe exhibited stagnant or increasing rates. …”

Experiment 3 –trial E. by Ottavia Benedicenti (9100619)

“…RNA or DNA yields are shown in terms of cycle quantification (Cq) values, where the y-axis is reversed from high to low numbers since RNA or DNA yield increases with decreased Cq-values. Trial E tested two different filtration flow rates: 200 mL/min (peristaltic pump) and 3.8 to 4.0 L/min (vacuum pump). …”

Understanding the role of moths (Insecta: Lepidoptera) as pollinators of apple (<i>Malus domestica</i>) by Pallab Chatterjee (20394206)

“…Climate change and various human activities have decreased pollinator diversity in apple orchards, leading many farmers to use honeybee colonies to increase productivity. …”

Implementation and clinical impact of an interdisciplinary tool to promote skin integrity after flap surgery in Veterans with spinal cord injury by Byron Eddy (6281057)

“…This paper describes the development and implementation of the Minneapolis Spinal Cord Optimization, Rehabilitation and Empowerment (SCORE), a preoperative interdisciplinary tool for risk assessment and mitigation, and reports its effect on the one-year flap failure rate (significant breakdown).…”

Image 1_Application and validation of the machine learning-based multimodal radiomics model for preoperative prediction of lateral lymph node metastasis in papillary thyroid carcin... by Jia-Wei Feng (10754067)

“…Background<p>Papillary thyroid carcinoma (PTC) frequently develops lateral lymph node metastasis (LLNM) in 12.6%-32.8% of patients, increasing recurrence risk and mortality. Current diagnostic methods show significant limitations, with occult LLNM rates of 41.0%-51.7% requiring secondary surgeries. …”

Supplementary file 1_Spatiotemporal monitoring in beidagang wetland using Landsat time-series images and Google Earth Engine during 2000–2022.docx by Xinyue Zhang (271120)

“…This study presents a promising method combining Landsat time-series images, DT and GEE for continuous land cover monitoring. …”

Digitized maps of vascular plant species distributions in Denmark in the early 20th century by Ditte Marie Christiansen (12182972)

“…<p dir="ltr"><b>Historic data are essential for quantifying changes in biodiversity and drivers thereof. A large part of such legacy data are stored undigitized in archives at e.g., natural history museums, and make up significant untapped resources for insights into past biodiversity patterns. …”

PRMT5 isoforms during zebrafish developmental stages by Zain Zakaria (20354028)

“…</p><p dir="ltr">Similarly, real-time RT-PCR analysis at the same developmental stages showed that prmt5 mRNA can be detected 1 hpf and its levels increase slightly by 18 to 72 hpf. Remarkably, despite the lack of any significant change in prmt5 mRNA levels between 18 and 72 hpf, Prmt5 protein expression showed dynamic changes at 18 and 72 hpf, which were accompanied by a change in mobility of Prmt5 protein at 72 hpf compared to other developmental stages.…”

Experiment 2, trial D. by Ottavia Benedicenti (9100619)

“…RNA or DNA yields are shown in terms of cycle quantification (Cq) values, where the y-axis is reversed from high to low numbers since RNA or DNA yield increases with decreased Cq-values. Trial D tested four different lysis buffers in 4 mL volume (NucliSENS®, MagNA Pure 96 Bacteria, MagNA Pure 96 External, and DNA/RNA Shield™) using 200 mL/min flow rate setting (peristaltic pump) and “sandwich” filtration. …”

Data Sheet 1_Boundary currents in the Bransfield Strait: near-surface interbasin water volume and heat exchange.pdf by Marta Veny (20937656)

“…Heat transport analyses reveal significant asymmetries: the Bransfield Current contributes up to 5.44x10¹² W eastward in summer based on a hydrographic climatology constructed from CTD, MEOP, and Argo float measurements (0–100 m depth) and 6.67x10¹¹ W using remotely-sensed sea surface temperature (0–10 m depth). …”

Excel raw data. by Michael Getie (12400923)

“…P-values below 0.05 were seen as a sign of a statistically significant difference.…”

Table 1_Unveiling the global impact of hypertensive heart disease among individuals aged ≥ 65 years: metabolic risk factors and future projections for 2050.xlsx by Ning An (618997)

“…Metabolic risks, particularly high systolic blood pressure, were significant contributors to HHD-related mortality and DALYs, with a pronounced impact in high-SDI regions. …”