Image_2_ATG5 and ATG7 Expression Levels Are Reduced in Cutaneous Melanoma and Regulated by NRF1.jpg حسب Živa Frangež (5946392)

"…Results from immunohistochemistry show that the expression of ATG5 and ATG7 is significantly reduced in melanoma tissues compared to benign nevi. …"

Data Sheet 1_Distribution of different plant life forms on tropical islands: patterns and underlying mechanisms.docx حسب Chengfeng Yang (3333489)

"…Introduction<p>Island biogeography theory posits that both island area and isolation significantly influence species distribution patterns and community structure. …"

Table_1_ATG5 and ATG7 Expression Levels Are Reduced in Cutaneous Melanoma and Regulated by NRF1.docx حسب Živa Frangež (5946392)

"…Results from immunohistochemistry show that the expression of ATG5 and ATG7 is significantly reduced in melanoma tissues compared to benign nevi. …"

Supplementary file 1_Burden of ageing spectrum of diseases in China, 1990–2021: a systematic analysis of global burden of disease study 2021.pdf حسب Li Yang (6520)

"…</p>Results<p>From 1990 to 2021, The ASR of all-cause DALYs in China decreased by 35.94% overall and by 33.99% among individuals ≥65 years. …"

Data Sheet 4_The power of GM-CSF: immune regulation in the defense against Phialophora verrucosa infection.pdf حسب Qi Dong (119569)

"…</p>Results<p>Compared to WT mice, GM-CSF deficiency significantly delayed fungal clearance and prolonged disease progression, accompanied by reduced inflammatory responses and decreased neutrophil infiltration. …"

Data Sheet 1_Early boosting of p38 MAPK signaling pathway by lycorine hydrochloride potently inhibits PRRSV proliferation in primary and established cells.pdf حسب Lizhan Su (19936980)

"…Mechanistically, LH treatment induced a rapid up-regulation of p38 MAPK signaling pathway in both infected and uninfected cells, which enhanced the expressions of NLRP3 and Caspase-1 proteins, thereby promoting the conversion of pro-IL-1β to IL-1β, which led to decreased PRRSV replication. In summary, this study reveals that early boosting of p38 MAPK signaling pathway induced by LH treatment significantly suppresses PRRSV propagation, and LH has the potential to be used as a novel antiviral agent against PRRSV infections.…"

Table 3_Speckle tracking technology and investigation of risk factors for premature ventricular contraction-induced cardiomyopathy.pdf حسب Qiao Ma (136536)

"…Regression analysis revealed that asymptomatic PVCs, paired/interpolated PVCs, wide QRS duration (≥150 ms), and higher PVC burden were significantly associated with decreased GLS and GCS magnitude. …"

Data Sheet 1_The CaSBP11 gene functions as a negative regulator in pepper drought stress.doc حسب Huai-Xia Zhang (8493453)

"…Our results revealed that drought conditions significantly upregulated CaSBP11 expression, whereas ABA treatment suppressed it. …"

Health Risks of Low-Dose Dietary Exposure to Triphenyl Phosphate and Diphenyl Phosphate in Mice: Insights from the Gut–Liver Axis حسب Jing Cao (287196)

"…TPHP intake affected the levels of short-chain fatty acids and bile acids in the gut, enhancing the production of 29 medium- and long-chain fatty acids in the liver by 3.72-fold and significantly increasing hepatic lipid and cholesterol levels. …"

Four-site distal paravertebral blocks improve physiologic indicators of analgesia in the immediate postoperative period as opposed to a three-site distal paravertebral block حسب Kelley Varner (16899048)

"…Clinical Relevance: Adding a fourth injection site at L3 decreases physiologic indicators of postoperative discomfort.…"

Image_3_Loss of Cdc42 causes abnormal optic cup morphogenesis and microphthalmia in mouse.JPEG حسب Katrina S. Hofstetter (17545425)

"…EdU incorporation is significantly downregulated. In addition, mitotic retinal progenitor cells mislocalize deeper, basal regions, likely contributing to decreased proliferation. …"

Image 1_Impact of social factors and health campaigns on the burden of idiopathic epilepsy: an inequality, decomposition, generalized and synthetic difference-in-differences study.... حسب Xuewen Rong (6242657)

"…The slope index of inequality for the mortality burden decreased from 1.97 to 1.62. After the policy shock, the age-standardized rate (ASR) of years lived with disability (YLD) in the Caribbean increased significantly to 4.59 (95% CI: 0.96 to 8.22), while the all-age YLD rate in the U.S. increased (5.18, 95% CI: 0.66 to 9.70) for both sexes.…"

Tobacco and alcohol use are the risk factors responsible for the greatest burden of head and neck cancers: a study from the Global Burden of Disease Study 2019 حسب Yue Yuan (113839)

"…Interestingly, the ASIRs for laryngeal cancer showed a decreasing trend over the studied time frame from 1990 to 2019. …"

Supplementary file 1_Transcriptional and neurotransmitter signatures of cerebral spontaneous neural activity in nurses with burnout.docx حسب Chun-Mei Song (21716903)

"…</p>Results<p>Nurses with burnout exhibited significantly decreased precuneus fALFF and reduced precuneus-right dorsolateral prefrontal cortex (DLPFC) FC compared to controls. …"

Data Sheet 1_Effects of pathogen infection and Rhizobium inoculation on instantaneous and long-term water use efficiency of peanut with and without drought.docx حسب Girmaye Benti Regassa (21592523)

"…Inoculation Fusarium sp. and co-inoculation Rhizobium and Fusarium sp. reduced WUE_i by decreasing plant height with drought. Inoculation Rhizobium and Fusarium sp. significantly reduced WUE_L by lowering intercellular CO₂ concentration without drought. …"

Supplementary Material for: Quality of Life After Alloplastic vs. Autologous Breast Reconstruction: 'The Influence of Patient Characteristics on Outcomes' حسب Holt-Kedde I.L. (20616542)

"…Conclusion: This study confirms that even when adjusted for confounders, scores on two QoL sub-scales autologous breast reconstruction patients score significantly higher over time. Although autologous reconstruction remained superior regarding “Satisfaction with Breasts”, scores decreased in autologous reconstruction patients when they were depressed at baseline, underwent radiotherapy, had a history of breast cancer, or faced major complications.…"

Data Sheet 1_Inhibition SIRT1 to regulate FOXP3 or RORγt can restore the balance of Treg/Th17 axis in ulcerative colitis and enhance the anti-inflammatory effect of moxibustion.pdf... حسب Yuanbing Zhu (20538638)

"…Differential gene expression and immune infiltration analysis showed that upstream transcription factors, including Forkhead box P3 (FOXP3), were significantly disrupted. In vitro cytology experiments, the results indicate that SIRT1 is activated in LPS induced inflammation, subsequently perturbing the Treg/Th17 immune balance axis. …"

Data Sheet 1_Efgartigimod for the treatment of immune checkpoint inhibitor-associated myocarditis complicated with impending crisis state of myasthenia gravis: a case report.pdf حسب Mingjia Lu (21593324)

"…Treatment with efgartigimod (10 mg/kg) significantly improved myasthenic symptoms, with Myasthenia Gravis–Activities of Daily Living (MG-ADL) and Quantitative Myasthenia Gravis (QMG) scores decreasing from 11 to 5 and 26 to 11, respectively. …"

Table 1_Age-Period-Cohort analysis and 2036 projections of the burden of ischemic stroke in Finland, Korea, Singapore and China, 1990–2021.docx حسب Jiayue Zhang (7832669)

"…</p>Results<p>The global all-age disability-adjusted life year (DALY) rate of ischemic stroke decreased by 34.90% between 1990 and 2021, with the highest disease burden in China, especially in males. …"

Data Sheet 1_KAE ameliorates LPS-mediated acute lung injury by inhibiting PANoptosis through the intracellular DNA-cGAS-STING axis.zip حسب Yonghu Chen (2040136)

"…</p>Results<p>KAE significantly alleviated lipopolysaccharide-induced pulmonary injury by reducing inflammatory cell infiltration, alleviating pulmonary edema, enhancing antioxidant capacity, and decreasing levels of inflammatory cytokines in mouse lung tissues. …"