Structure–Activity Relationships of Azaquinazolinone Derivatives as ¹⁸F‑Labeled PET Probes Targeting Ghrelin Receptors by Hiroyuki Watanabe (312793)

“…In a biodistribution study using normal mice, [¹⁸F]AQ-12 displayed high uptake in the pancreas, which is one of the GHSR-expressing organs, and its radioactivity was significantly decreased by coinjection with unlabeled AQ-12. …”

Projected global leukemia burden, 1990-2050. by Chengjun Hu (588206)

“…Methods: From 1990 to 2021, we analyzed age-standardized rates (ASR) trends across 204 countries and territories, utilizing the estimated annual percentage change (EAPC). …”

Correlation between HDI and EAPC. by Chengjun Hu (588206)

“…Methods: From 1990 to 2021, we analyzed age-standardized rates (ASR) trends across 204 countries and territories, utilizing the estimated annual percentage change (EAPC). …”

Global leukemia incidence and EAPC, 1990-2021. by Chengjun Hu (588206)

“…Methods: From 1990 to 2021, we analyzed age-standardized rates (ASR) trends across 204 countries and territories, utilizing the estimated annual percentage change (EAPC). …”

Participant retention flowchart. by Carolin Oetzmann (11397968)

“…We identified a 4-class solution: (1) severe with appetite decrease, (2) severe with appetite increase, (3) moderate severity and (4) low severity. …”

DataSheet1_The OsGAPC3 mutation significantly affects grain quality traits and improves the nutritional quality of rice.docx by Bo Peng (273834)

“…The number and volume of type-II protein bodies in the endosperm of the OsGAPC3 mutants, and GPC increase significantly. We report significant increases in chalkiness area and degree, and decreases for starch content, gel consistency, and taste value. …”

Raw data. by Jia Zhu (135506)

“…Biomechanical results revealed that the ROM of the surgical segment had decreased significantly under six basic working conditions following NZ implantation. …”

Cohort characteristics. by Fernanda Talarico (807333)

“…</p><p>Results</p><p>The analysis reveals a significant decrease in all health services utilization from 2016 to 2019, followed by an increase until 2022. …”

Table 1_Dual variants of uncertain significance in a case of hyper-IgM syndrome: implications for diagnosis and management.docx by Nourhen Agrebi (14151222)

“…</p>Objective<p>This study aims to elucidate the clinical implications of concurrent AICDA and IKBKB homozygous variants in a pediatric patient diagnosed with hyper-IgM syndrome.</p>Methods<p>We present immunological and genetic analysis of a Tunisian patient with two homozygous variants of uncertain significance (VUSs) in the IKBKB and AICDA genes, suspected of causing hyper-IgM and immune deficiency. …”

Image 2_Case report: Significant lesion reduction and neural structural changes following ibogaine treatments for multiple sclerosis.jpeg by David Qixiang Chen (8198265)

“…Ibogaine, a psychoactive alkaloid, has been proposed as a potential neuroregenerative agent due to its multifaceted pharmacological profile. We present two case studies of MS patients who underwent a novel ibogaine treatment, highlighting significant neuroimaging changes and clinical improvements. …”

Image 1_Case report: Significant lesion reduction and neural structural changes following ibogaine treatments for multiple sclerosis.jpeg by David Qixiang Chen (8198265)

“…Ibogaine, a psychoactive alkaloid, has been proposed as a potential neuroregenerative agent due to its multifaceted pharmacological profile. We present two case studies of MS patients who underwent a novel ibogaine treatment, highlighting significant neuroimaging changes and clinical improvements. …”

Summary of measured parameters. by Aaron L. Sayler (19797446)

“…Male KO mice also displayed a significant decrease in rearing activity and blood pressure. …”

Raw data. by Aaron L. Sayler (19797446)

“…Male KO mice also displayed a significant decrease in rearing activity and blood pressure. …”

S1 Graphical abstract - by Aman Goyal (19231397)

“…</p><p>Conclusions</p><p>Our analysis showed a significant decrease in mortality from paroxysmal tachycardia since 1999, although there has been a slight increase in recent years. …”

Flowchart of patient selection in this study. by Kazuyoshi Ohkawa (836847)

“…Among the letrozole-treated patients, the mean FIB-4 index tended to decline during letrozole treatment; a significant decrease was observed at 18 and 24 months compared with the baseline values (p = 0.044 and p = 0.013). …”

S1 Data - by Kazuyoshi Ohkawa (836847)

“…Among the letrozole-treated patients, the mean FIB-4 index tended to decline during letrozole treatment; a significant decrease was observed at 18 and 24 months compared with the baseline values (p = 0.044 and p = 0.013). …”

DataSheet1_Significant nocturnal wakefulness after sleep onset in metabolic dysfunction–associated steatotic liver disease.PDF by Sofia Schaeffer (20379954)

“…Further, data from sleep questionnaires proved sleep-wake disruption in patients with MASLD. We objectively assessed sleep-wake rhythms in patients with biopsy-proven MASLD (n = 35) and healthy controls (HC, n = 16) using actigraphy 24/7 for 4 weeks. …”

DataSheet3_Significant nocturnal wakefulness after sleep onset in metabolic dysfunction–associated steatotic liver disease.PDF by Sofia Schaeffer (20379954)

“…Further, data from sleep questionnaires proved sleep-wake disruption in patients with MASLD. We objectively assessed sleep-wake rhythms in patients with biopsy-proven MASLD (n = 35) and healthy controls (HC, n = 16) using actigraphy 24/7 for 4 weeks. …”

DataSheet2_Significant nocturnal wakefulness after sleep onset in metabolic dysfunction–associated steatotic liver disease.PDF by Sofia Schaeffer (20379954)

“…Further, data from sleep questionnaires proved sleep-wake disruption in patients with MASLD. We objectively assessed sleep-wake rhythms in patients with biopsy-proven MASLD (n = 35) and healthy controls (HC, n = 16) using actigraphy 24/7 for 4 weeks. …”

DataSheet4_Significant nocturnal wakefulness after sleep onset in metabolic dysfunction–associated steatotic liver disease.PDF by Sofia Schaeffer (20379954)

“…Further, data from sleep questionnaires proved sleep-wake disruption in patients with MASLD. We objectively assessed sleep-wake rhythms in patients with biopsy-proven MASLD (n = 35) and healthy controls (HC, n = 16) using actigraphy 24/7 for 4 weeks. …”