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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
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apoA2 correlates to gestational age with decreased apolipoproteins A2, C1, C3 and E in gestational diabetes
Published 2021“…</p><h3>Conclusions</h3><p dir="ltr">Apoproteins apoA2, apoC1, apoC3 and apoE are decreased in women with GDM and may have a role in inflammation, as apoA2 and C3 correlated with CRP. …”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…<p dir="ltr">Coronavirus Disease of 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has resulted in a massive health crisis across the globe, with some genetic variants gaining enhanced infectivity and competitive fitness, and thus significantly aggravating the global health concern. …”
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
Published 2019“…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …”
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Burden and disease pathogenesis of influenza and other respiratory viruses in diabetic patients
Published 2022“…Vaccinating diabetic patients against influenza would significantly reduce hospitalization due to disease severity. …”
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”
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The Epidemiology of Herpes Simplex Virus Type 1 in Asia: Systematic Review, Meta-analyses, and Meta-regressions
Published 2018“…<h3>Background</h3><p dir="ltr">Herpes simplex virus type 1 (HSV-1) epidemiology in Asia was characterized by assessing seroprevalence levels and extent to which HSV-1 is isolated from clinically diagnosed genital ulcer disease (GUD) and genital herpes.…”
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Household food insecurity and nutritional status of pre-school children following relaxation of corona virus disease-2019 (COVID-19) restrictions
Published 2025“…Background & aimsStudies found a high prevalence of household food insecurity (HFI) and malnutrition and an association between them during the movement restriction period of the corona virus disease-2019 (COVID-19) pandemic. This nutritional status should have improved by now as movement restrictions, including quarantine, have been lifted. …”
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Presence of high-risk HPVs, EBV, and MMTV in human triple-negative breast cancer
Published 2021“…<p dir="ltr">Breast cancer, the most frequent disease amongst women worldwide, accounts for the highest cancer-related mortality rate. …”
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Impact of COVID‑19 pandemic restrictions and subsequent relaxation on the prevalence of respiratory virus hospitalizations in children
Published 2024“…Rhinovirus was the dominant virus during the COVID-19 (39.1%) and post-COVID-19 seasons (61%) compared to the pre-COVID-19 season (31.4%) (<i>P</i> < 0.001). …”
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Indomethacin as a Rescue Therapy for Patent Ductus Arteriosus in Extremely Premature Infants after Failed Ibuprofen Treatment
Published 2023“…<p dir="ltr">Hemodynamically significant patent ductus arteriosus (hsPDA) is a major cause of neonatal morbidity and mortality in extremely low birth weight (ELBW) infants. …”
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Eradication of hepatitis C virus infection in kidney transplant recipients using direct‐acting antiviral therapy: Qatar experience
Published 2020“…<h3>Introduction</h3><p dir="ltr">Hepatitis C virus (HCV) infection has detrimental effects on patient and graft survival after kidney transplantation. …”
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Epidemiological and genetic characterization of pH1N1 and H3N2 influenza viruses circulated in MENA region during 2009–2017
Published 2019“…</p><h3>Conclusions</h3><p dir="ltr">Molecular characterization of H1N1 and H3N2 viruses over 9 years revealed significant differences with regard to position and function of characterized substitutions. …”
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The Monkeypox Outbreak and Implications for Dental Practice
Published 2022“…<h3>Objectives</h3><p dir="ltr"><u>Monkeypox (MPX)</u> caused by the <u>MPX virus</u>, is a contagious disease confined mainly to African regions, and is currently making multiple appearances outside of disease-endemic countries. …”
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Plant Leaf Disease Detection Using Ensemble Learning and Explainable AI
Published 2024“…Much like human health, plants face susceptibility to diseases induced by viruses and bacteria, necessitating careful attention to plant care and disease identification. …”
