Supplementary Material for: Effects of roxadustat on thyroid profiles in patients and animals with chronic kidney disease by Li W. (3610583)

“…Among patients with initially normal thyroid function, 31 developed euthyroid sick syndrome post-roxadustat treatment. Treatment significantly decreased T3, FT3, FT4, and TSH levels, with TSH showing marked reduction within the first 10 weeks. …”

Table 1_Genomic and phenotypic characterization of two novel human-derived Limosilactobacillus reuteri strains with unique probiotic traits.docx by Lijuan Yang (1538233)

“…In co-culture with LS174T cells, both strains decrease the production of Mucin-2, a key component of the gut barrier, with LLR2 showing significantly greater efficacy. …”

Data_Sheet_2_Long-Term Overconsumption of Sugar Starting at Adolescence Produces Persistent Hyperactivity and Neurocognitive Deficits in Adulthood.PDF by Kate Beecher (6688340)

“…The long-term effects on cognitive processes and hyperactivity from sugar overconsumption, beginning at adolescence are not known. Using a well-validated mouse model of sugar consumption, we found that long-term sugar consumption, at a level that significantly augments weight gain, elicits an abnormal hyperlocomotor response to novelty and alters both episodic and spatial memory. …”

Data_Sheet_1_Long-Term Overconsumption of Sugar Starting at Adolescence Produces Persistent Hyperactivity and Neurocognitive Deficits in Adulthood.PDF by Kate Beecher (6688340)

“…The long-term effects on cognitive processes and hyperactivity from sugar overconsumption, beginning at adolescence are not known. Using a well-validated mouse model of sugar consumption, we found that long-term sugar consumption, at a level that significantly augments weight gain, elicits an abnormal hyperlocomotor response to novelty and alters both episodic and spatial memory. …”

Data Sheet 1_Study on the function of TTG1 gene in Camellia oleifera.docx by Chengcheng Xiang (5512442)

“…Heterologous expression resulted in: (1) significantly increased leaf trichome density (up to 114 trichomes/50 mm²); (2) enhanced seed anthocyanin accumulation (199–318% increase); and (3) substantial alterations in fatty acid composition, including 79% elevation in oleic acid (C18:1), 113% increase in gondoic acid (C20:1), 35% reduction in both linolenic (C18:3) and palmitic acids (C16:0), and 87% decrease in erucic acid (C22:1). …”

Table 1_Study on the function of TTG1 gene in Camellia oleifera.xlsx by Chengcheng Xiang (5512442)

“…Heterologous expression resulted in: (1) significantly increased leaf trichome density (up to 114 trichomes/50 mm²); (2) enhanced seed anthocyanin accumulation (199–318% increase); and (3) substantial alterations in fatty acid composition, including 79% elevation in oleic acid (C18:1), 113% increase in gondoic acid (C20:1), 35% reduction in both linolenic (C18:3) and palmitic acids (C16:0), and 87% decrease in erucic acid (C22:1). …”

Data Sheet 2_Phase 2 trial (NCI-COTC030) of adjuvant inhaled recombinant human IL-15 combined with amputation and adjuvant chemotherapy in dogs with appendicular osteosarcoma.pdf by Robert B. Rebhun (8479020)

“…Cytotoxicity assays of PBMCs showed significant decreases after both surgery and chemotherapy with an overall decrease from the start to end of therapy (-18.2 ± 16.1%, P<0.001). …”

Data Sheet 1_Phase 2 trial (NCI-COTC030) of adjuvant inhaled recombinant human IL-15 combined with amputation and adjuvant chemotherapy in dogs with appendicular osteosarcoma.pdf by Robert B. Rebhun (8479020)

“…Cytotoxicity assays of PBMCs showed significant decreases after both surgery and chemotherapy with an overall decrease from the start to end of therapy (-18.2 ± 16.1%, P<0.001). …”

Supplementary file 1_Global, regional, and national burden of older adult atopic dermatitis in 204 countries and territories worldwide.docx by Yi Ou (9116831)

“…SDI relative and frontier analysis exhibited that incidence, prevalence and DALYs rates were positively correlated with SDI levels, while SDI-related inequalities had a significant decrease. Predictions up to 2050 anticipated increasing older adult AD incidence, prevalence, and DALYs numbers, while only age-standardized disability-adjusted life-year rates (ASDRs) were expected to decline.…”

Table1_Tle6 deficiency in male mice led to abnormal sperm morphology and reduced sperm motility.docx by Kousuke Kazama (19937214)

“…Tle6 knockout males exhibited a reduced total sperm count compared to wild-type mice, with a marked decrease in highly motile sperm. …”

Supplementary Material for: Acute myelin oligodendrocyte glycoprotein (MOG)-IgG optic neuritis without optic nerve enhancement by Jeyanathan B. (20374227)

“…While acute MOG-ON usually presents with optic nerve enhancement, recognizing atypical presentations is critical in accurate diagnosis and effective management. Case Presentation: We herein present a case of a 67-year-old woman presenting with sudden decrease in vision in the right eye. …”

Image 1_Multi-omics analysis reveals neutrophil heterogeneity and key molecular drivers in sepsis-associated acute kidney injury.jpg by Tianle Cheng (20788417)

“…We identified four neutrophil subtypes—pro-inflammatory, anti-inflammatory, mature, and immature—revealing a significant increase in pro-inflammatory neutrophils in sepsis (40.53% versus 4.19% in controls) and a decrease in anti-inflammatory neutrophils (18.43% versus 27.04%). …”

Image 2_Multi-omics analysis reveals neutrophil heterogeneity and key molecular drivers in sepsis-associated acute kidney injury.jpg by Tianle Cheng (20788417)

“…We identified four neutrophil subtypes—pro-inflammatory, anti-inflammatory, mature, and immature—revealing a significant increase in pro-inflammatory neutrophils in sepsis (40.53% versus 4.19% in controls) and a decrease in anti-inflammatory neutrophils (18.43% versus 27.04%). …”

Neural timescales increase with cognitive demands. by Isabel Raposo (21615517)

“…Timescales in the period following search display onset (red dashed line) and after button press (black dashed line) decrease in pop-out condition relative to visual search condition returning to baseline around 1s (black bar represents significant time points <i>p</i> < 0.05). …”

Table 1_Trends and projections of the burden of disease for male infertility in China from 1990 to 2021: an analysis from the Global Burden of Disease 2021 study.xlsx by Ran Xu (316855)

“…In addition, the trend for both was a gradual increase over time until 1994 and a gradual decrease over time after 1994. …”

Data Sheet 1_Cytosine methylase and hydroxymethylase activity in mammalian mitochondria.pdf by Lisa S. Shock (14913542)

“…CRISPR/Cas9-mediated inactivation of mtDNMT1 and/or DNMT3b activity resulted in a stepwise decrease in mitochondrial methylation across the heavy and light strand promoters of mtDNA, with a significant reduction in transcription of several mtDNA-encoded OXPHOS genes. …”

Table1_Bidirectional two-sample Mendelian randomization analysis investigates causal associations between cathepsins and inflammatory bowel disease.DOCX by Na Wang (193263)

“…Reverse Mendelian randomization analyses suggested that UC might lead to elevated cathepsin G levels [inverse-variance weighted (IVW): p = 0.038, b = 9.966], and CD might cause a decrease in cathepsin B levels [IVW: p = 0.002, b = −10.525] and cathepsin L1 levels [IVW: p = 0.045, b = −4.742].…”

Data Sheet 1_Non-stationary response of Pacific saury (Cololabis saira) in the northwestern Pacific to climate variability.docx by Chang Cao (2592700)

“…The dynamics of Pacific saury from 1970 to 2021 could be divided into four periods: the 1970s and 1980s when the Siberian High and the intensification of the East Asian winter monsoon drove down the water temperature, providing a suitable habitat and resulting in an increase in resource abundance; In the 1990s, the rise in temperature led to a reduction in resource abundance; At the beginning of the 21st century, the enhancement of the Siberian High brought about a suitable habitat, and the resource abundance showed a significant increase; The unfavorable high water temperature environment in the 2010s caused the resource abundance to decrease once again. …”

DataSheet1_Bidirectional two-sample Mendelian randomization analysis investigates causal associations between cathepsins and inflammatory bowel disease.DOCX by Na Wang (193263)

“…Reverse Mendelian randomization analyses suggested that UC might lead to elevated cathepsin G levels [inverse-variance weighted (IVW): p = 0.038, b = 9.966], and CD might cause a decrease in cathepsin B levels [IVW: p = 0.002, b = −10.525] and cathepsin L1 levels [IVW: p = 0.045, b = −4.742].…”

DataSheet2_Bidirectional two-sample Mendelian randomization analysis investigates causal associations between cathepsins and inflammatory bowel disease.DOCX by Na Wang (193263)

“…Reverse Mendelian randomization analyses suggested that UC might lead to elevated cathepsin G levels [inverse-variance weighted (IVW): p = 0.038, b = 9.966], and CD might cause a decrease in cathepsin B levels [IVW: p = 0.002, b = −10.525] and cathepsin L1 levels [IVW: p = 0.045, b = −4.742].…”