Table 1_Coptis japonica Makino ethanol extracts attenuates cancer cachexia induced muscle and fat wasting through inhibition of the STAT3 signaling pathway.docx by Yo Sep Hwang (17967916)

“…This research aimed to explore the potential of CJM extracts (CJME) in mitigating cancer cachexia in both myotubes treated with CT26 conditioned medium (CM) and in a CT26-induced cancer cachexia mouse model. Our results demonstrated that CJME significantly decreased the mRNA and protein levels of muscle-specific E3 ubiquitin ligases Atrogin-1 and MuRF1 in myotubes exposed to CT26 CM. …”

Table 2_Role of miR-144-5p in modulating lipid metabolism and potentially alleviating obesity via the PGC-1α/AMPK pathway.xlsx by Siriguleng Yu (14555900)

“…Introduction<p>MiR-144-5p is differentially expressed in plasma exosomes from Bactrian camels of varying body sizes, with GO and KEGG analyses indicating that its target genes play crucial roles in lipid metabolism. PGC-1α, confirmed as a key target through RNA pull-down and dual-luciferase reporter assays, is a significant regulator of this process. …”

Image 1_Clinical study of PLA2R epitope spreading for predicting proteinuria remission in primary membranous nephropathy.pdf by Xueyang Cheng (22473883)

“…In the RTX group, epitope spreading significantly decreased at M6 (P = 0.004), and four patients (22.2%) with no clinical remission were ARA-positive. …”

Data Sheet 1_Resistance characteristics of culture-positive tuberculosis from 2015 to 2022.xlsx by Zhenzhen Wang (250368)

“…The overall TB resistance rates were significantly higher in the main urban areas. During the study period, the proportion of mono-resistance tuberculosis (MR-TB), multidrug-resistant tuberculosis (MDR-TB) and polydrug-resistant tuberculosis (PDR-TB) decreased by 59.2% (12.9–5.3%), 40.3% (12.4–7.4%), and 68.3% (6.9–2.2%), respectively. …”

Table2_Global, regional, and national time trends in ischaemic heart disease incidence over three decades (1990–2019): an age-period-cohort analysis of the global burden of disease... by Juan Tang (437969)

“…Age effects across all countries and genders demonstrated an increasing trend over time, indicating age as a significant risk factor for IHD. Moreover, period and cohort effects in higher SDI countries exhibited a more rapid decline in both genders compared to lower SDI countries. …”

Table1_Global, regional, and national time trends in ischaemic heart disease incidence over three decades (1990–2019): an age-period-cohort analysis of the global burden of disease... by Juan Tang (437969)

“…Age effects across all countries and genders demonstrated an increasing trend over time, indicating age as a significant risk factor for IHD. Moreover, period and cohort effects in higher SDI countries exhibited a more rapid decline in both genders compared to lower SDI countries. …”

Datasheet1_Global, regional, and national time trends in ischaemic heart disease incidence over three decades (1990–2019): an age-period-cohort analysis of the global burden of dis... by Juan Tang (437969)

“…Age effects across all countries and genders demonstrated an increasing trend over time, indicating age as a significant risk factor for IHD. Moreover, period and cohort effects in higher SDI countries exhibited a more rapid decline in both genders compared to lower SDI countries. …”

<i>Salmonella </i>Typhimurium <i>StiP</i>-mediated upregulation of membrane protein Alx drives complement evasion via CFI-dependent C3b degradation by jin guan (21792620)

“…Typhimurium, among which the <i>StiP</i> deletion strain (263<i>ΔStiP</i>) showed the greatest serum resistance reduction (2.49-fold). We further explored the role of <i>StiP</i> in host blood environment adaptation and found that 263<i>ΔStiP</i> displayed 3.12-fold reduced HeLa cell adhesion, 3.74-fold lower HeLa cell invasion, 1.92-fold decreased intra-macrophage survival, and 50% reduced serum resistance versus wild-type 263 (WT263), collectively indicating that <i>StiP</i> is critical for host blood environment adaptation in invasive <i>S</i>. …”

Identifying cyst initiation candidate genes through mRNA sequencing <i>Pkd2</i> mouse kidneys at pre-cystic and early cystic time points. by Abigail O. Smith (11883787)

“…Colored dots indicate FDR <0.05, red indicates increased expression and blue decreased expression in Experimental vs Control. (C) The intersection between P6 DEGs (91) and P10 DEGs (5,309) includes 74 genes which we defined as cyst initiation candidates (CICs). …”

Table 1_Lannea edulis lowers blood glucose by modulating absorption, utilization, and pancreatic function in diabetic rats.docx by Gilbert Lutangu (21898643)

“…Treatment with 0.5 mg/mL of the leaf extract significantly decreased the movement of glucose from the mucosal side to the serosa in the everted rat jejunum (p < 0.001) and significantly increased glucose uptake by the hemidiaphragm at 1 mg/mL (p = 0.0029) and 2 mg/mL (p = 0.0479). …”

Data Sheet 1_Wilt disease reshapes rhizosphere microbiota in small yellow ginger soils.docx by Qing Sun (492552)

“…</p>Results<p>Ginger wilt disease significantly altered the rhizosphere soil bacterial community structure and composition: the relative abundance of Proteobacteria increased significantly, primarily due to the enrichment of the genus Ralstonia; conversely, the relative abundance of Acidobacteriota, Firmicutes, and Chloroflexi significantly decreased. …”

TRIM16 mediates secretory autophagy in head and neck cancer-associated fibroblasts by Thuc Ly (12832686)

“…Using both a literature based, and an unbiased approach, we studied the molecular machinery involved in autophagosome trafficking in CAFs. …”

Data Sheet 1_Constraint-based modeling of bioenergetic differences between synaptic and non-synaptic components of dopaminergic neurons in Parkinson’s disease.zip by Xi Luo (361139)

“…</p>Results<p>All models predicted that oxidative phosphorylation plays a significant role under lower energy demand, while glycolysis predominates when energy demand exceeds mitochondrial constraints. …”

Table 1_Constraint-based modeling of bioenergetic differences between synaptic and non-synaptic components of dopaminergic neurons in Parkinson’s disease.docx by Xi Luo (361139)

“…</p>Results<p>All models predicted that oxidative phosphorylation plays a significant role under lower energy demand, while glycolysis predominates when energy demand exceeds mitochondrial constraints. …”

Data from: The impact and production of the Old World climbing fern (Lygodium microphyllum) biological control agent Lygomusotima stria, is affected by the level of host plant fert... by GREGORY WHEELER (18437559)

“…Here, we report the results of greenhouse studies that examined the performance of the Lygomusotima stria larvae and their impact on the target weed when grown at a range of fertilizer and insect damage levels. …”

Data Sheet 6_StACS3-mediated drought stress adaptation in potato involves interactions with StPP2C2 and St14-3-3 proteins.pdf by Sadia Hamera (22524803)

“…In contrast, silencing StACS3 significantly reduces stress-induced ethylene accumulation and enhances drought resilience, including decreased cell death and increased antioxidant activity. …”

Movie 1 TRAF7^fl*/fl* vs. WT. by Erdyni N. Tsitsikov (20384719)

“…<div><p>Here, we describe a spontaneous mouse mutant with a deletion in a predicted gene <i>2310061I04Rik</i> (<i>Rik</i>) of unknown function located on chromosome 17. …”

Images analyzed for Fig 7. by Erdyni N. Tsitsikov (20384719)

“…<div><p>Here, we describe a spontaneous mouse mutant with a deletion in a predicted gene <i>2310061I04Rik</i> (<i>Rik</i>) of unknown function located on chromosome 17. …”

Image 2_StACS3-mediated drought stress adaptation in potato involves interactions with StPP2C2 and St14-3-3 proteins.tiff by Sadia Hamera (22524803)

“…In contrast, silencing StACS3 significantly reduces stress-induced ethylene accumulation and enhances drought resilience, including decreased cell death and increased antioxidant activity. …”

Table 2_Dynamic changes in platelet counts and psychological state in ITP patients after COVID-19 infection.docx by Xiaoli Chen (102563)

“…Interestingly, it was found that there was a transient elevation in platelet counts (PC) of ITP patients after COVID-19 infection, which then gradually decreased to the previous level after recovering from virus, including three subgroups comparation: PC >100 × 10⁹/L vs. …”