Functional Delivery Systems for Targeting Tumor Heterogeneity: Reversing Immunosuppression and Modulating Cancer-Immune Interplay by Di Han (618795)

“…By developing a delivery vector that specifically targets circulating malignant cells (CMCs) in patient blood samples, we established an ex vivo platform to study the dynamic interplay between patient-derived cancer cells and immune cells. …”

Summary of KEGG enrichment analysis. by Zeynab Hosseinpoor (19762319)

“…While the expression levels of <i>IRS2</i>, <i>FOXO1</i>, and <i>ERK2</i> (<i>MAPK1</i>) were significantly decreased, the <i>SERPINF1</i> gene exhibited high expression simultaneously. pAAV-delivered <i>MIR-96</i> had no adverse effect on the viability of human RPE cells. …”

Histogram of the area factorψ. by Hong Zhang (25820)

“…The measured <i>I</i>_s decreases following a power-law trend as <i>β</i> and <i>D</i> increase, with weathering reducing the sensitivity of <i>I</i>_s to <i>β</i> but not significantly altering its sensitivity to <i>D</i>. …”

Raw dataset Fig. 6. by Hong Zhang (25820)

“…The measured <i>I</i>_s decreases following a power-law trend as <i>β</i> and <i>D</i> increase, with weathering reducing the sensitivity of <i>I</i>_s to <i>β</i> but not significantly altering its sensitivity to <i>D</i>. …”

Schematic for measuring <i>D</i> and <i>D</i>′ values. by Hong Zhang (25820)

“…The measured <i>I</i>_s decreases following a power-law trend as <i>β</i> and <i>D</i> increase, with weathering reducing the sensitivity of <i>I</i>_s to <i>β</i> but not significantly altering its sensitivity to <i>D</i>. …”

Primer sequences for RT-qPCR. by Wenlong Shen (9313937)

“…Data from TCGA showed that NCOA4 shows greater downgrade in tumor tissues than in non-tumor tissues and the overall survival (OS) of patients with low NCOA4 expression was significantly shorter than that of patients with high NCOA4 expression.The qPCR results showed that NCOA4 was expressed at low levels in cholangiocarcinoma tissue specimens; the mRNA expression of NCOA4 decreased after knocking down NCOA4 in cells. …”

siRNA sequences and negative controls sequences. by Wenlong Shen (9313937)

“…Data from TCGA showed that NCOA4 shows greater downgrade in tumor tissues than in non-tumor tissues and the overall survival (OS) of patients with low NCOA4 expression was significantly shorter than that of patients with high NCOA4 expression.The qPCR results showed that NCOA4 was expressed at low levels in cholangiocarcinoma tissue specimens; the mRNA expression of NCOA4 decreased after knocking down NCOA4 in cells. …”

Antibodies used in the study. by Wenlong Shen (9313937)

“…Data from TCGA showed that NCOA4 shows greater downgrade in tumor tissues than in non-tumor tissues and the overall survival (OS) of patients with low NCOA4 expression was significantly shorter than that of patients with high NCOA4 expression.The qPCR results showed that NCOA4 was expressed at low levels in cholangiocarcinoma tissue specimens; the mRNA expression of NCOA4 decreased after knocking down NCOA4 in cells. …”

General characteristics of study subjects. by Soo-Hee Hwang (17767519)

“…COVID-19 did not affect inpatient mortality (p = 0.9608), but in-hospital mortality decreased from 12% to 7% in the medical aid group.</p><p>Conclusion</p><p>Overall, we found that COVID-19 had an impact on admission rates of patients with AMI but did not have a significant impact on in-hospital mortality. …”

Accuracy on the ERAM task. by Daisung Jang (16781451)

“…Existing research suggests that accuracy is higher during the follicular phase and ovulation compared to the luteal phase, but findings are inconsistent. Using a repeated measures design with a sample of healthy naturally cycling women (N = 63), we investigated whether emotion recognition accuracy varied between the follicular and luteal phases, and whether accuracy related to levels of estrogen (estradiol) and progesterone. …”

PRISMA flow diagram of study selection. by Masoud Rahmati (16665456)

“…<div><p>Background</p><p>Vision impairment is a common disability that poses significant challenges to individuals’ ability to perform activities essential for independent living, including activities of daily living (ADL) and instrumental activities of daily living (IADL). …”

General characteristics of included studies. by Masoud Rahmati (16665456)

“…<div><p>Background</p><p>Vision impairment is a common disability that poses significant challenges to individuals’ ability to perform activities essential for independent living, including activities of daily living (ADL) and instrumental activities of daily living (IADL). …”

Characteristics of individual studies. by Masoud Rahmati (16665456)

“…<div><p>Background</p><p>Vision impairment is a common disability that poses significant challenges to individuals’ ability to perform activities essential for independent living, including activities of daily living (ADL) and instrumental activities of daily living (IADL). …”

Table2_Significant nocturnal wakefulness after sleep onset in metabolic dysfunction–associated steatotic liver disease.DOCX by Sofia Schaeffer (20379954)

“…<p>Metabolic dysfunction–associated steatotic liver disease (MASLD) is a multisystemic disease with a multifactorial pathogenesis involving dietary, environmental, and genetic factors. …”

Table1_Significant nocturnal wakefulness after sleep onset in metabolic dysfunction–associated steatotic liver disease.DOCX by Sofia Schaeffer (20379954)

“…<p>Metabolic dysfunction–associated steatotic liver disease (MASLD) is a multisystemic disease with a multifactorial pathogenesis involving dietary, environmental, and genetic factors. …”

Gene expression omnibus datasets. by Xinyi Xia (7516694)

“…Functional enrichment analysis revealed that inflammation played a significant role. Based on shared genes, TCMR was divided into two clusters. …”

Basic characteristics of the afforested land. by Yao Zhong (280645)

“…Notably, bacterial β-diversity exhibited a significant negative correlation with MAOC content, offering a new perspective on the role of microbes in carbon stabilization. …”

Study Flowchart. by Jae-Heung Cho (798319)

“…Despite no significant differences in pain reduction at week 5, CMT was found to be a cost-effective treatment for TMD, particularly for improving function and quality of life. …”

Changes in outcomes over time. by Jae-Heung Cho (798319)

“…Despite no significant differences in pain reduction at week 5, CMT was found to be a cost-effective treatment for TMD, particularly for improving function and quality of life. …”

Study timetable. by Jae-Heung Cho (798319)

“…Despite no significant differences in pain reduction at week 5, CMT was found to be a cost-effective treatment for TMD, particularly for improving function and quality of life. …”