Improved Accuracy and Reliability in Untargeted Analysis with LC-ESI-QTOF/MS¹ by Ensemble Averaging by Guillaume Laurent Erny (21000926)

“…It was proved that ensemble averaging allows an increase in the S/N up to a factor of 10, and the relative standard deviation of the accurate masses and retention time decreased by a factor of 10. …”

Improved Accuracy and Reliability in Untargeted Analysis with LC-ESI-QTOF/MS¹ by Ensemble Averaging by Guillaume Laurent Erny (21000926)

“…It was proved that ensemble averaging allows an increase in the S/N up to a factor of 10, and the relative standard deviation of the accurate masses and retention time decreased by a factor of 10. …”

Connectivity between the left nucleus accumbens and two clusters. by Karel Joineau (21799908)

“…After intervention there was a significant decrease in the FR group (mean at V1: 0.249 ± 0.094, mean at V5: 0.130 ± 0.101, difference: −0.119 ± 0.097, p < 0.001) and a significant increase in the SM group (mean at V1: 0.156 ± 0.113, mean at V5: 0.287 ± 0.107, difference: 0.131 ± 0.066, p < 0.001). …”

Cyclization Decoded: Engineering Amylomaltase for Efficient α‑Glucan Transformations by Han Liu (288039)

“…Furthermore, we identify that postglycosylation noncovalent polysaccharide chain transfer emerges as the decisive factor in cyclization, particularly for AM–degree of polymerization (DP) greater than 30 substrate complexes, where this noncovalent step (≥13.6 kcal/mol) dictates the rate of CA production. 57 variants with enhanced activity (up to a 2.3-fold increase) were engineered in our biochemical experiments by strategically modulating the chain transfer step. …”

The patients discharged before the next weekend stratified by day of admission and serum sodium. by Rajkumar Rajendram (22505442)

Kaplan-Meier survival analysis comparing patients admitted before or during the COVID-19 period. by Rajkumar Rajendram (22505442)

In-Hospital Mortality by Admission Day and Serum Sodium Category (Excluding Hypernatremia). by Rajkumar Rajendram (22505442)

Thirty-day inpatient survival by admission serum sodium concentration: Kaplan-Meier analysis stratified by pre- and during-COVID-19 pandemic periods. by Rajkumar Rajendram (22505442)

Heatmap analysis for technical reproducibility of Cohort #1 CP dataset (28wk-old WT and R14^Δ/+). by Brian Foo (19273132)

Effect of the POM cycles on selected metabolites. by Bonnie A. McNeil (22331601)

Cinnamaldehyde is a specific ligand for HL-IR. by Ceyan Kuang (8554557)

Flowchart of study population. by Yan Zeng (120271)

“…</p><p>Conclusions</p><p>In MM patients in ICU, both minimum and maximum PLT were significantly associated with an increased risk of in-hospital mortality in critical ill patients with MM. …”

Primer sequences. by Ceyan Kuang (8554557)

“…Microinjection of HL-IR double-stranded RNA (dsRNA) showed that reduced transcript levels led to significant decreases in the tick repellency rate from cinnamaldehyde and the EAG response of Haller’s organ. …”

Current vaccine delivery model. by Pamela Bakkabulindi (12914980)

“…Monthly distribution costs decreased from $494.8 ($0.07 per child) to $445.9 ($0.06 per child). …”

Vaccine stock status, Gomba district, Uganda. by Pamela Bakkabulindi (12914980)

“…Monthly distribution costs decreased from $494.8 ($0.07 per child) to $445.9 ($0.06 per child). …”

Informed push model. by Pamela Bakkabulindi (12914980)

“…Monthly distribution costs decreased from $494.8 ($0.07 per child) to $445.9 ($0.06 per child). …”

Source of funds for vaccine pick-up at baseline. by Pamela Bakkabulindi (12914980)

“…Monthly distribution costs decreased from $494.8 ($0.07 per child) to $445.9 ($0.06 per child). …”

S1 Dataset - by Pamela Bakkabulindi (12914980)

“…Monthly distribution costs decreased from $494.8 ($0.07 per child) to $445.9 ($0.06 per child). …”

Discovery of NP3-742: A Structurally Diverse NLRP3 Inhibitor Identified through an Unusual Phenol Replacement by Juraj Velcicky (2201350)

“…Initial indole analog <b>7</b> demonstrated a robust in vivo IL-1β inhibition, but also a significant hERG inhibition. Decreasing lipophilicity led to the discovery of <b>NP3-742</b>, demonstrating a favorable overall profile including diminished hERG inhibition and in vivo efficacy in a mouse peritonitis model.…”

Discovery of NP3-742: A Structurally Diverse NLRP3 Inhibitor Identified through an Unusual Phenol Replacement by Juraj Velcicky (2201350)

“…Initial indole analog <b>7</b> demonstrated a robust in vivo IL-1β inhibition, but also a significant hERG inhibition. Decreasing lipophilicity led to the discovery of <b>NP3-742</b>, demonstrating a favorable overall profile including diminished hERG inhibition and in vivo efficacy in a mouse peritonitis model.…”