Data Sheet 1_Comprehensive analysis of metabolism-related genes in sepsis reveals metabolic–immune heterogeneity and highlights GYG1 as a potential therapeutic target.csv by Jie Zheng (31208)

“…In vivo, Gyg1 was markedly upregulated in septic mice, and LNP-mediated siRNA knockdown of Gyg1 significantly improved survival in the LPS model. Mechanistically, Gyg1 knockdown significantly reduced glycogen content in myeloid cells, attenuated IL-6 and TNF-α production, alleviated LPS-induced neutrophil, and modestly decreased CD40 expression in monocytes and dendritic cells. …”

Data Sheet 1_Impact of liposomal bupivacaine on subjective recovery quality after surgery: a meta-analysis of randomized controlled trials.docx by Longyi Zhang (11120151)

“…The LB group also exhibited lower cumulative morphine-equivalent opioid consumption within 72 h after surgery, a reduced incidence of PONV, and significantly higher patient satisfaction scores.</p>Conclusion<p>The use of LB was associated with improved QoR scores within 72 h after surgery, a reduced incidence of PONV, and decreased opioid consumption. …”

Table 1_Molecular epidemiological characteristics of pertussis in a pediatric hospital in Jinan City, China, 2022 to 2024.docx by Miao Liu (148274)

“…BP co-detection rates with specific pathogens—human rhinovirus, adenovirus, Haemophilus influenzae, Staphylococcus aureus, and Mycoplasma pneumoniae significantly increased (all P_trend < 0.05), whereas parainfluenza virus co-infections decreased (P_trend < 0.05). …”

Data Sheet 1_Global, regional and national mortality burden of laryngeal cancer attributable to occupational exposure to sulfuric acid and asbestos: 1990–2021 and projections to 20... by Xin Gong (592328)

“…Disease burden varies significantly across SDI regions, suggesting that preventive measures should be tailored to specific SDI levels.…”

Table 1_Therapeutic potential of Triptolide in inhibiting breast cancer-induced bone destruction – PTHrP as a therapeutic target.docx by Wu Di (11561998)

“…</p>Results<p>TP treatment significantly reduced osteoclastogenesis in both co‐culture and conditioned medium systems. …”

Data Sheet 3_Global, regional and national mortality burden of laryngeal cancer attributable to occupational exposure to sulfuric acid and asbestos: 1990–2021 and projections to 20... by Xin Gong (592328)

“…Disease burden varies significantly across SDI regions, suggesting that preventive measures should be tailored to specific SDI levels.…”

Data Sheet 1_Prepandemic levels of cytokines and immunoglobulins and risk of SARS-CoV-2 infection and COVID-19 in the general population of Barcelona.docx by Miquel Porta (199379)

“…</p>Results<p>Higher concentrations in 2016–17 of IL-8 and TNF-α significantly decreased the risk of SARS-CoV-2 seropositivity in 2020–21, whereas higher concentrations of MIP-1α were a risk factor for seropositivity. …”

Data Sheet 2_Global, regional and national mortality burden of laryngeal cancer attributable to occupational exposure to sulfuric acid and asbestos: 1990–2021 and projections to 20... by Xin Gong (592328)

“…Disease burden varies significantly across SDI regions, suggesting that preventive measures should be tailored to specific SDI levels.…”

SEAwise report on the impact of socioeconomic effects of fisheries management adapted according to input from review workshops by Isabella Bitetto (20145735)

“…For demersal fleets, variable prices caused significant income shifts, though operational effort was independent of price. …”

Additional file 1 of MDM2-amplified esophageal adenocarcinomas exhibit an activated metabolic and immunosuppressive phenotype with multiple potential therapeutic targets by Karl Knipper (15016346)

“…Volcano plot of all detected proteins comparing the proteome of neoadjuvantly treated MDM2-amplified and non-amplified tumors. Grey: not significantly different expressed, blue: significantly decreased expression in neoadjuvantly treated MDM2-amplified tumors, red: significantly increased expression in neoadjuvantly treated MDM2-amplified tumors. …”

Supplementary Data for article '<b>Long-term biochar amendment alters microbial necromass carbon accumulation in topsoil and subsoil of two contrasting croplands: Alfisol and Ultis... by Zhiwei Liu (17302867)

“…Compared to the biochar-free control, biochar amendment significantly increased total necromass C (TNC) by 45.9% in the topsoil of Ultisol but decreased it by 9.9% in Alfisol. …”

Data Sheet 1_Perilipin 5 alleviates ferroptosis of cardiomyocytes by targeting USP10-p53-TfR proteasome-dependent degradation.docx by Jianqiao Zhao (14519036)

“…</p>Methods<p>H9c2 cells were treated with H₂O₂ and Erastin, while the rat model of MI was established by ligating the left anterior descending coronary artery.</p>Results<p>We found that after MI, cardiac subcellular iron levels increased and the expression of PLIN5 decreased. …”

Data Sheet 1_Global, regional, and national trends and burden of hypertensive disorders in pregnancy among women of childbearing age from 1990 to 2021.pdf by Zhongyun Tang (21287855)

“…</p>Conclusion<p>Over the past 32 years, HDP prevalence cases and incidence cases have risen globally, but death cases and DALYs cases have significantly decreased, particularly in low SDI regions and the 25–29 age group. …”

Table 1_GRHL2-HER3 and E-cadherin mediate EGFR-bypass drug resistance in lung cancer cells.xlsx by Fumiya Ito (14833366)

“…However, resistance to EGFR inhibitors, such as erlotinib, presents a significant challenge in treating lung cancer. In this study, we established an EGFR-independent, erlotinib-resistant (ER) phenotype in lung cancer A549 cells by exposing them to erlotinib for an extended period. …”

Data Sheet 2_The ERF transcription factor TaERF13-2B functions as a negative regulator of drought tolerance in Arabidopsis and wheat.docx by Yang Yu (4292)

“…TaERF13-2B overexpression in Arabidopsis resulted in significantly reduced survival rates under drought conditions with decreased expression of stress-responsive and antioxidant enzyme genes, indicating that the TaERF13-2B gene elevated drought sensitivity in transgenic Arabidopsis. …”

Table 1_Puf4 -mediated oxidative stress virulence attenuation in Cryptococcus neoformans.docx by Chenhao Suo (7022351)

“…</p>Methods<p>In this study, we systematically investigated the role of Puf4 in the metabolism and virulence of C. neoformans using RNA sequencing (RNA-seq), biochemical analysis, and in vivo animal experiments.…”

Presentation1_Leaf nutrient traits exhibit greater environmental plasticity compared to resource utilization traits along an elevational gradient.zip by Xing Zhang (11943)

“…Generally, as elevation increased, SLA decreased, while LDMC significantly increased (P < 0.001), and LN first increase and then decreased (P < 0.001). …”

Data Sheet 1_GRHL2-HER3 and E-cadherin mediate EGFR-bypass drug resistance in lung cancer cells.pdf by Fumiya Ito (14833366)

“…However, resistance to EGFR inhibitors, such as erlotinib, presents a significant challenge in treating lung cancer. In this study, we established an EGFR-independent, erlotinib-resistant (ER) phenotype in lung cancer A549 cells by exposing them to erlotinib for an extended period. …”

Table 1_Global, regional, and national trends and burden of hypertensive disorders in pregnancy among women of childbearing age from 1990 to 2021.xlsx by Zhongyun Tang (21287855)

“…</p>Conclusion<p>Over the past 32 years, HDP prevalence cases and incidence cases have risen globally, but death cases and DALYs cases have significantly decreased, particularly in low SDI regions and the 25–29 age group. …”

Data Sheet 1_The ERF transcription factor TaERF13-2B functions as a negative regulator of drought tolerance in Arabidopsis and wheat.docx by Yang Yu (4292)

“…TaERF13-2B overexpression in Arabidopsis resulted in significantly reduced survival rates under drought conditions with decreased expression of stress-responsive and antioxidant enzyme genes, indicating that the TaERF13-2B gene elevated drought sensitivity in transgenic Arabidopsis. …”