Image 3_Beta-hydroxybutyrate (BHB) elicits concentration-dependent anti-inflammatory effects on microglial cells which are reversible by blocking its monocarboxylate (MCT) importer... by Chase Garcia (21803576)

“…</p>Results<p>At this concentration, BHB significantly and concentration-dependently decreased the following: 1) inflammatory cytokine expression (IL-6, TNF-α, and IL-1β), 2) inflammatory morphological changes, and 3) activation of p-ERK and p-p38MAPK, which are key pathways involved in microglial inflammation. …”

Data Sheet 1_Global, regional, and national burdens of endometriosis from 1990 to 2021: a trend analysis.docx by Hailan Yan (18174379)

“…Background<p>Endometriosis is a common, chronic, estrogen-dependent gynecological disorder that significantly affects patients’ quality of life. However, the disease burden and its trends may be undergoing significant changes, and comprehensive data on this issue are currently lacking. …”

<b><i>Original data for "High risk of soil available silicon deficiency in bamboo forest: Insights from bamboo afforestation chronosequences in the karst region of southwest China"... by Kangning Yan (22751487)

“…Furthermore, aboveground Si content decreased significantly from leaves (10.54–21.45 g kg–1) to branches (3.81–5.61 g kg–1) and culms (1.07–1.98 g kg–1). …”

Data Sheet 1_Brown adipocyte exosome - derived C22:6 inhibits the IL-1β signaling pathway to alleviate rheumatoid arthritis.pdf by Rui Jiang (264894)

“…Introduction<p>Rheumatoid arthritis (RA) is an autoimmune disorder characterized by significant disability and teratogenic effects, for which there are few effective curative therapies. …”

Supplementary Material for: Additive inhibition of HERG channels expressed in Xenopus oocytes by antipsychotic drugs and citrus juice flavonoid naringenin by Yang K.-H.S. (18331101)

“…Methods: In the present study, we evaluated the effect of combining naringenin with antipsychotics on the function of HERG channels expressed in Xenopus oocytes. …”

Method for establishing the multipath adaptive mitigation model considering deformation displacement of monitoring stations by Guo Zihuai (20442074)

“…The comparison between MAMM and the Multipath Hemispherical Model (MHM) indicates that, in the simulated displacement experiments, MHM’s effectiveness in mitigating multipath errors significantly decreases as the actual displacement distance increases, whereas MAMM consistently maintains an improvement rate in positioning precision of over 100%, markedly surpassing that of MHM. …”

S1 File - by Qian Wang (32718)

“…Prior cancer history had little impact on DSS; however, the presence of prior solid cancer history, latency period of 10+ years, and prior administration of radiotherapy or chemotherapy significantly decreased OS. Prior cancer history had no effect on DSS, but survival compromised OS under specific circumstances.…”

Table 1_The impact of digital economy on the supply chain resilience of cross-border healthcare e-commerce.xlsx by Jianyu Liu (313522)

“…The results indicate that the digital economy significantly enhance supply chain resilience, with reduced reliance on foreign trade, increased export technology complexity, and decreased export concentration being key pathways for this improvement. …”

Data Sheet 1_China’s readiness for transitioning to a low-carbon economy: mitigant and catalyst factors for a geopolitical conflict.zip by Yan Chen (4308)

“…This study examines the relationship between Low-Carbon Economic Development (LCED) and Geopolitical Risk (GPR) in China by focusing on the challenges and opportunities they present. We use a qualitative analysis to identify that rising GPR, exacerbated by market instability, resource allocation conflicts, and trade disputes, significantly hinders LCED progress. …”

Supplementary Material for: Diverse Obesity Trajectories in a Family including Identical Twins with a Pathogenic MC4R Variant by figshare admin karger (2628495)

“…Twin 2 had a sedentary lifestyle and epilepsy and had a peak BMI of 30.1 kg/m2; she responded well to naltrexone-bupropion and BMI decreased to 26 kg/m2. Conclusion: The manifestation of obesity, even in cases of monogenic obesity, can vary significantly due to the influence of environmental and lifestyle factors.…”

Data Sheet 1_Ribosomal protein L9 is a potential therapeutic target for B-ALL through the activation of the p53 signaling pathway.docx by Xinxin Li (281237)

“…Although recent advancements have highlighted the pivotal role of ribosomes in the progression of B-ALL, the specific function of ribosomal protein L9 (RPL9), a key component of ribosomal structural protein, still unclear. In this study, we observed a significant upregulation of RPL9 in human B-ALL cells compared to normal B cells, suggesting RPL9’s potential key role in B-ALL progression. …”

Renal function and risk of dementia: a Mendelian randomization study by Haowen Huang (1430386)

“…At the stratum of genetic susceptibility, we tested the causal relationship between variations index in renal function and the occurrence of dementia. …”

Image 1_Yacon root is a functional food beneficial for human health: a meta-analysis of clinical trials.pdf by Ling-Hui Pan (9341084)

“…The pooled results showed that YR significantly reduced BMI [SMD = −0.81, 95%CI (−1.54, −0.08)], decreased stool pH [SMD = −1.12, 95%CI (−1.61, −0.62)], softened stools [SMD = 0.94, 95%CI (0.08, 1.80)], facilitated defecation [SMD = 4.03, 95% CI (0.54, 7.52)], improved fiber consumption patterns [SMD = 0.58, 95%CI (0.18, −0.99)]. …”

Table 1_Association of inflammatory biomarkers with new functional morbidity at hospital discharge in children who survive severe sepsis.docx by Mallory A. Perry-Eaddy (20842868)

“…</p>Methods<p>We conducted a post hoc secondary analysis of the MitoPSe clinical study, including N = 119 critically ill children who survived sepsis. …”

Image 2_Age-dependent effects of H2S on post-traumatic stress disorder in adolescent and adult mice.jpeg by Bing Gu (276393)

“…In addition, we found that high dose H₂S could improve anxiety and depression-like behavior, mitigate synaptic plasticity deficits, and activate the CREB/BDNF signaling pathway, as well as increase H₂S levels in the hippocampus. …”

Image 3_Impact of social factors and health campaigns on the burden of idiopathic epilepsy: an inequality, decomposition, generalized and synthetic difference-in-differences study.... by Xuewen Rong (6242657)

“…The slope index of inequality for the mortality burden decreased from 1.97 to 1.62. After the policy shock, the age-standardized rate (ASR) of years lived with disability (YLD) in the Caribbean increased significantly to 4.59 (95% CI: 0.96 to 8.22), while the all-age YLD rate in the U.S. increased (5.18, 95% CI: 0.66 to 9.70) for both sexes.…”

Data Sheet 2_Red mite (Panonychus citri) attack amplifies citrus rootstock-driven responses in physiological and biochemical traits, VOC emission, and expression of defence-related... by Tommy Rioja (22179742)

“…<p>Citriculture faces significant constraints in expanding into new environments and agroecological zones. …”

Thermodynamic properties of non-azeotropic refrigerant heat pumps under full operating conditions with non-phase-change heat sinks and heat soucres by Hemin Hu (21488860)

“…<p>When using pure refrigerants in heat pump, a significant temperature mismatch arises between hot and cold fluids within the evaporator and condenser, adversely impacting the thermal efficiency of system. …”

Table 2_CqHKT1 and CqSOS1 mediate genotype-dependent Na+ exclusion under high salinity conditions in quinoa.xlsx by Yasufumi Kobayashi (5481530)

“…By contrast, K⁺ accumulation was slightly reduced in the aerial parts but significantly decreased in the roots of all the genotypes. …”

Data Sheet 2_Screening of neurotransmitter receptor modulators reveals novel inhibitors of influenza virus replication.pdf by Yarou Gao (20620991)

“…In a mouse model of lethal influenza, isoxsuprine significantly decreased lung viral titers, mitigated pulmonary inflammation, and enhanced survival rates. …”