Table 1_Metabolites mediate the effects of healthy lifestyles on the risks of common age-related diseases.xlsx حسب Yan Li (23143)

"…Background<p>Limited research is available on the associations between healthy lifestyles and age-related diseases, particularly those involving multiple diseases and their underlying mechanisms. We aimed to determine whether healthy lifestyles are associated with a lower likelihood of age-related diseases, and whether metabolites mediate these associations.…"

Supplementary file 1_Metabolites mediate the effects of healthy lifestyles on the risks of common age-related diseases.docx حسب Yan Li (23143)

"…Background<p>Limited research is available on the associations between healthy lifestyles and age-related diseases, particularly those involving multiple diseases and their underlying mechanisms. We aimed to determine whether healthy lifestyles are associated with a lower likelihood of age-related diseases, and whether metabolites mediate these associations.…"

Data Sheet 1_Modified life’s essential 8 mediate the correlation between dietary index for gut microbiota and sleep disorders.docx حسب Juanjuan Fang (413481)

"…We used mediation analysis to assess the intermediary role of mLE8 (Modified Life’s Essential 8) and all its components.…"

Table_1_Oxidative stress and inflammation mediate the association between elevated oxidative balance scores and improved sleep quality: evidence from NHANES.docx حسب Qu Zhang (486455)

"…Multivariable logistic and linear regression models were employed to investigate the correlation between OBS and sleep quality. …"

The role of IRF-1 in mediating T-cell immune imbalance in systemic lupus erythematosus and the construction of a diagnostic model حسب Zichen Huang (6587885)

Table 1_Inverse associations of the lifestyle critical 9 with cardiorenal syndrome: the mediating role of the dietary inflammatory index.docx حسب Hongman Li (19546419)

"…The dose–response curve illustrates a linear relationship between LC9 and CRS; as LC9 increases, the occurrence of CRS decreases. …"

Data Sheet 1_Inverse associations of the lifestyle critical 9 with cardiorenal syndrome: the mediating role of the dietary inflammatory index.xlsx حسب Hongman Li (19546419)

"…The dose–response curve illustrates a linear relationship between LC9 and CRS; as LC9 increases, the occurrence of CRS decreases. …"

Data Sheet 1_Association of the dietary index for gut microbiota with sleep disorder among US adults: the mediation effect of dietary inflammation index.docx حسب Yingying Li (50341)

"…Mediation analysis showed that DII significantly mediated the relationship between DI-GM and sleep disorders, with a mediation proportion of 27.36% (p < 0.001).…"

Supporting datasets for all figures. حسب Matthew Drill (22258391)

"…Inhibition of P2X7R with small molecule antagonist AZ10606120, for 72 hours significantly decreased U251 cell number (p < 0.0001), and significantly increased tumour cell death, as evidenced by increased LDH release (p < 0.001). …"

Table 1_Association between estimated glucose disposal rate and the risk of atherosclerotic cardiovascular disease: insight from cross-sectional and retrospective cohort studies.do... حسب Zixuan Wang (35190)

"…</p>Conclusion<p>This study elucidates the significant negative dose-response linear relationship of eGDR with ASCVD risk and the partial mediation effects of AIP, VAI, CMI, LAP, and BMI, highlighting the significance of enhancing glucose-utilizing capacity in decreasing the risk of ASCVD.…"

Flow chart of research object screening. حسب Wenyao Xie (21567889)

"…Estradiol exhibited significant non-linear relationship with ALI (P = 0.027), with multiple inflection points suggesting concentration-dependent effects.…"

Table 1_The association between lutein and zeaxanthin intake and multi-level biological aging.docx حسب Meiyi Tao (17040531)

"…The study aims to explore how LZ intake affects the biological aging progression, particularly in organs like the liver, kidneys, and cardiovascular system, and explore the potential mechanism of lutein as the main carotenoid mediating this effect.</p>Methods<p>We analyzed biological aging using biological age calculations based on data from the NHANES 2007–2015 database. …"

Table 1_Inverse association between triglyceride–glucose index and maximal oxygen uptake in US young and middle-aged population: a cross-sectional study.docx حسب Bin Zhang (64682)

"…</p>Results<p>The complex sampling design and mobile examination center sample weights were considered. In multivariable linear regression analyses, each 1 unit increase in the TyG index was associated with a decrease in VO₂max [β = −1.24, 95% CI (−1.97, −0.51), p = 0.002] when expressed as a continuous variable, independent of confounders. …"

Table 1_Negative pressure breathing: the response of human respiration and circulation to different levels of rarefaction during inspiration.docx حسب Yury S. Semenov (20345100)

"…</p>Results<p>Tidal volume increased, respiratory rate decreased under NPBin with no significant changes in minute ventilation. …"

Table 1_Association of cardiovascular health with reproductive lifespan and pregnancy loss: insights from NHANES 2005–2018.pdf حسب Yang Yan (222441)

"…Furthermore, a linear correlation was observed between CVH and reproductive lifespan (P<0.001), while the number of pregnancy losses decreased as CVH levels increase within a certain range and approximately presented an L-shaped relationship (P=0.009). …"

Table 2_Association of cardiovascular health with reproductive lifespan and pregnancy loss: insights from NHANES 2005–2018.docx حسب Yang Yan (222441)

"…Furthermore, a linear correlation was observed between CVH and reproductive lifespan (P<0.001), while the number of pregnancy losses decreased as CVH levels increase within a certain range and approximately presented an L-shaped relationship (P=0.009). …"

<b>Circular RNA encoding relaxin-2 as a potential therapy for liver fibrosis</b> حسب jiewen zhong (21472721)

"…<p dir="ltr">Circular RNAs (circRNAs) have recently emerged as a promising new drug modality with significant therapeutic potential due to their higher stability and lower immunogenicity than linear mRNAs. …"

Data Sheet 1_Interstitial fluid transport in linea alba is involved in acupuncture-induced attenuation of ovarian hypofunction in aged rats.pdf حسب Yaoyao Zhu (3487937)

"…</p>Methods<p>We used fluorescence imaging to observe ISF migration patterns in the linea alba of rats, where conception vessel acupoints are located. …"