Novel Small-Molecule miR-124 Inducer Acts as “a Physiological Brake” of Inflammation in Ulcerative Colitis by Targeting the PIK3R2/PI3K/Akt Axis by Tiantian Wang (1688881)

“…This study identified FHND5032, a novel small-molecule miR-124 inducer, as a potent therapeutic candidate for UC. We found that FHND5032 significantly upregulated miR-124 expression in macrophages, surpassing the clinical-stage comparator ABX464 in vitro and in vivo. …”

Development of a User-Friendly Dynamic Culture System for Decellularized Scaffold-Based Tissue Engineering by Shujuan Fan (8380047)

“…Compared to static controls, constructs cultured in our platform exhibited a > 5-fold increase in proliferating (Ki67+) cells and a 32-fold decrease in apoptotic (TUNEL+) cells. Hepatic functions were also significantly enhanced, with increased urea production and markedly higher expression of albumin (∼1.5-fold) and the key metabolic enzymes UGT1 (∼1.4-fold) and CYP2D6 (∼2.7-fold). …”

Data Sheet 1_Perceived benefits and barriers to the use of long-acting injectable antiretroviral treatment among adolescents and young people living with HIV in Western Kenya: qual... by Shukri A. Hassan (14245301)

Data Sheet 2_Perceived benefits and barriers to the use of long-acting injectable antiretroviral treatment among adolescents and young people living with HIV in Western Kenya: qual... by Shukri A. Hassan (14245301)

Synthesis and Biological Evaluation of Peripheral 5HT_2B Antagonists for Liver Fibrosis by Jihyeon Yoon (8705706)

“…<b>19c</b> showed robust <i>in vitro</i> activity with an IC₅₀ value of 1.09 nM and limited blood–brain barrier penetration. Furthermore, <b>19c</b> did not significantly inhibit hERG and cytochrome P450 enzymes. …”

Synthesis and Biological Evaluation of Peripheral 5HT_2B Antagonists for Liver Fibrosis by Jihyeon Yoon (8705706)

“…<b>19c</b> showed robust <i>in vitro</i> activity with an IC₅₀ value of 1.09 nM and limited blood–brain barrier penetration. Furthermore, <b>19c</b> did not significantly inhibit hERG and cytochrome P450 enzymes. …”

Stepped wedge cluster randomized trial design. by Antonio Marty Quispe (12574259)

“…Peridomestic mosquito counts, BPN, and BPH did not differ significantly between renovated and non-renovated households. …”

Separable Microneedle Patch Integrated with the Dictamnine-Loaded Copper MOF Nanozyme for Atopic Dermatitis Treatment by Shuyun Liu (692804)

“…In a 1-Chloro-2,4-dinitrochlorobenzene (DNCB)-induced AD mouse model, the Dic@pCu-HA MN significantly reduced oxidative stress (8-OHdG: 85.1 ± 7.0% decrease), suppressed pro-inflammatory cytokines (IL-4: 70.0 ± 7.8% decrease vs control), and restored skin barrier integrity. …”

Separable Microneedle Patch Integrated with the Dictamnine-Loaded Copper MOF Nanozyme for Atopic Dermatitis Treatment by Shuyun Liu (692804)

“…In a 1-Chloro-2,4-dinitrochlorobenzene (DNCB)-induced AD mouse model, the Dic@pCu-HA MN significantly reduced oxidative stress (8-OHdG: 85.1 ± 7.0% decrease), suppressed pro-inflammatory cytokines (IL-4: 70.0 ± 7.8% decrease vs control), and restored skin barrier integrity. …”

Separable Microneedle Patch Integrated with the Dictamnine-Loaded Copper MOF Nanozyme for Atopic Dermatitis Treatment by Shuyun Liu (692804)

“…In a 1-Chloro-2,4-dinitrochlorobenzene (DNCB)-induced AD mouse model, the Dic@pCu-HA MN significantly reduced oxidative stress (8-OHdG: 85.1 ± 7.0% decrease), suppressed pro-inflammatory cytokines (IL-4: 70.0 ± 7.8% decrease vs control), and restored skin barrier integrity. …”

Separable Microneedle Patch Integrated with the Dictamnine-Loaded Copper MOF Nanozyme for Atopic Dermatitis Treatment by Shuyun Liu (692804)

“…In a 1-Chloro-2,4-dinitrochlorobenzene (DNCB)-induced AD mouse model, the Dic@pCu-HA MN significantly reduced oxidative stress (8-OHdG: 85.1 ± 7.0% decrease), suppressed pro-inflammatory cytokines (IL-4: 70.0 ± 7.8% decrease vs control), and restored skin barrier integrity. …”

Data Sheet 1_Photodynamic inactivation of Staphylococcus aureus with rose bengal reduces superantigen activity.docx by Patrycja Ogonowska (5644274)

“…Across in vitro, ex vivo, and murine in vivo models, RB-mediated aPDI significantly decreased S. aureus viability and markedly attenuated the expression and activity of staphylococcal enterotoxins. …”

Image 4_Impact of DRG policy on the performance of tertiary hospital inpatient services in Chongqing, China: an interrupted time series study, 2020–2023.png by Yunyu Liu (11739052)

“…</p>Results<p>We found significant changes in the following indicators since the implementation of the DRG policy: case-mix index (CMI) level increased by 0.0661 (p = 0.02), but the trend decreased by 0.0071 (p < 0.001). …”

Image 1_Impact of DRG policy on the performance of tertiary hospital inpatient services in Chongqing, China: an interrupted time series study, 2020–2023.png by Yunyu Liu (11739052)

“…</p>Results<p>We found significant changes in the following indicators since the implementation of the DRG policy: case-mix index (CMI) level increased by 0.0661 (p = 0.02), but the trend decreased by 0.0071 (p < 0.001). …”

Image 2_Impact of DRG policy on the performance of tertiary hospital inpatient services in Chongqing, China: an interrupted time series study, 2020–2023.png by Yunyu Liu (11739052)

“…</p>Results<p>We found significant changes in the following indicators since the implementation of the DRG policy: case-mix index (CMI) level increased by 0.0661 (p = 0.02), but the trend decreased by 0.0071 (p < 0.001). …”

Image 3_Impact of DRG policy on the performance of tertiary hospital inpatient services in Chongqing, China: an interrupted time series study, 2020–2023.png by Yunyu Liu (11739052)

“…</p>Results<p>We found significant changes in the following indicators since the implementation of the DRG policy: case-mix index (CMI) level increased by 0.0661 (p = 0.02), but the trend decreased by 0.0071 (p < 0.001). …”

Table 2_Gandouling ameliorates Wilson’s disease-associated liver fibrosis in mice with associated faecal microbiome and metabolome remodeling.xlsx by Lulu Tang (2664904)

“…We sought to determine whether GDL may prevent liver fibrosis in toxic milk (TX) mice by assessing its ability to regulate gut microbiota, metabolites, and barrier function.…”

Table 1_Gandouling ameliorates Wilson’s disease-associated liver fibrosis in mice with associated faecal microbiome and metabolome remodeling.xlsx by Lulu Tang (2664904)

“…We sought to determine whether GDL may prevent liver fibrosis in toxic milk (TX) mice by assessing its ability to regulate gut microbiota, metabolites, and barrier function.…”

Study group background characteristics. by Zicheng Hu (3825313)

“…This relationship changed markedly with the development of <b><i>HAD</i></b> and the underlying direct neuropathic parenchymal CNS infection, i.e., <b><i>HIVE</i></b>, in which the CSF HIV-1 RNA concentrations reached high levels, and the differences between it and the blood viral load decreased. …”