Data_Sheet_1_A causal association between obesity and constipation: a two-sample bidirectional Mendelian randomization study and meta-analysis.zip by Xian Sun (655494)

“…Additionally, overweight in adults could decrease the risk of constipation [RR = 0.940 (0.827, 1.068)]. …”

Image 1_Comparative analysis of cranberry fruit rot fungal diversity in Massachusetts from wild, organic, and conventional ecosystems using multiplex PCR.jpg by Salisu Sulley (22059035)

“…Significant differences in the detection of CFR fungi were observed across these ecosystems. …”

Global, regional and national burden of colorectal cancer and its risk factors, 1990-2021: a systematic analysis for the GBD 2021 by Xuan Zeng (22461799)

“…<p dir="ltr"><b>Importance: </b>Colorectal cancer (CRC) constitutes a significant segment of the global cancer burden, thereby warranting an in-depth epidemiological appraisal to inform strategic public health interventions and resource allocation. …”

Table 1_Association of spicy food consumption with colorectal polyp and adenoma prevalence: findings from the Lanxi Pre-Colorectal Cancer Cohort (LP3C).docx by Peiling Hu (12259394)

“…</p>Results<p>Among 4,797 identified colorectal polyps and 2,607 adenomas, escalating spicy food intake exhibited a significant positive association with polyp risk (quartile 4 vs. quartile 1 OR: 1.24, 95% CI 1.13–1.37; P for trend < 0.001), contrasting with non-significant adenoma associations (quartile 4 vs. quartile 1 OR: 1.07, 95% CI 0.94–1.20; P for trend = 0.146), which was not clinically meaningful. …”

Table 1_Efficacy and safety of live combined Bacillus subtilis and Enterococcus faecium in patients with constipation: a meta-analysis of randomized controlled trials.docx by Wenwen Li (735004)

“…The defecation difficulty score tended to decrease in the experimental group relative to that in the control group, although this did not reach statistical significance [SMD (95% CI) = −1.924 (−3.947 to 0.099); p = 0.062]. …”

Image 1_Efficacy and safety of live combined Bacillus subtilis and Enterococcus faecium in patients with constipation: a meta-analysis of randomized controlled trials.tif by Wenwen Li (735004)

“…The defecation difficulty score tended to decrease in the experimental group relative to that in the control group, although this did not reach statistical significance [SMD (95% CI) = −1.924 (−3.947 to 0.099); p = 0.062]. …”

Ydj1 acetylation impacts multiple aspects of translation. by Siddhi Omkar (12413434)

“…Statistical significance was calculated via ANOVA. (*p < 0.05; **p 0.01).…”

Dataset. by Valéria Teresa Saraiva Lino (20390441)

“…In the intervention group, there was a significant decrease in the likelihood of violence against the elderly, with a 10-fold reduction. …”

CONSORT flow diagram. by Valéria Teresa Saraiva Lino (20390441)

“…In the intervention group, there was a significant decrease in the likelihood of violence against the elderly, with a 10-fold reduction. …”

Data Sheet 2_Modulation of gut microbiota by Gardeniae Fructus oil exerts TLR4/NF-κB/NLRP3 pathway-mediated antidepressant effects based on transcriptomics and fecal transplantatio... by Man Han (8444859)

“…</p>Results<p>Compared with the CON group, mice in the CUMS group showed significant depressive-like behavior, pathological damage to the hippocampus and colon tissues, significant decrease in levels of 5-HT, DA, and BDNF in the hippocampus, significant increase in levels of IL-1β, IL-6, TNF-α, DAO, and LPS in serum, significant decrease in colonic tight junction protein expression, and significant increase in protein expression of TLR4, p-NF-κB, NLRP3, ASC, and IL-1β in the hippocampus (P < 0.01); Compared with the CUMS group, the FMT group could effectively improve the above situation (P < 0.05, P < 0.01), whose therapeutic effect was second only to the OGF group (P < 0.01), while ABX + OGF group did not show obvious therapeutic effect.…”

Data Sheet 1_Modulation of gut microbiota by Gardeniae Fructus oil exerts TLR4/NF-κB/NLRP3 pathway-mediated antidepressant effects based on transcriptomics and fecal transplantatio... by Man Han (8444859)

“…</p>Results<p>Compared with the CON group, mice in the CUMS group showed significant depressive-like behavior, pathological damage to the hippocampus and colon tissues, significant decrease in levels of 5-HT, DA, and BDNF in the hippocampus, significant increase in levels of IL-1β, IL-6, TNF-α, DAO, and LPS in serum, significant decrease in colonic tight junction protein expression, and significant increase in protein expression of TLR4, p-NF-κB, NLRP3, ASC, and IL-1β in the hippocampus (P < 0.01); Compared with the CUMS group, the FMT group could effectively improve the above situation (P < 0.05, P < 0.01), whose therapeutic effect was second only to the OGF group (P < 0.01), while ABX + OGF group did not show obvious therapeutic effect.…”

Table 1_Real world efficacy and safety of the advanced hybrid closed-loop system MiniMed 780G (SmartGuard) in children under 7 years of age.docx by Sara López-López (20505704)

“…In Group 2, there was a significant increase in the TIR (7%; p = 0,000) and a significant decrease in the TAR (7%; p = 0,000 for TAR1 and 6.5%; p = 0,001 for TAR2). …”

CYP4B1 overexpression protects AC-16 cells from Ang Ⅱ-induced hypertrophy. by Li Dai (159381)

“…(<b>D</b>) qRT-PCR analyses showed significant <i>CYP4B1</i> decrease in Ang Ⅱ-treated AC-16 cells. …”

Table 1_Efficacy of thymosin α1 for sepsis: a systematic review and meta-analysis of randomized controlled trials.docx by Bin Gu (223694)

“…These observations underscore the significance of personalized immunotherapy strategies in forthcoming clinical trials.…”

Data Sheet 1_Shrunken pore syndrome in relation to morbidity and mortality in the population-based Malmö Diet and Cancer cohort: a generalized propensity score approach.docx by Anna Åkesson (2046415)

“…An explanation is a selective decrease in the filtration of substances of different masses, and this condition is referred to as “Shrunken pore syndrome” (SPS). …”

Table 5_Coordinated regulation of IGF1R by HIF1α and HIF2α enhances chemoresistance in glioblastoma.docx by Bin Liao (714989)

“…Simultaneous knockout of HIF1α and HIF2α in GBM cells resulted in the highest LDH release and apoptosis rates under hypoxic conditions, accompanied by the most significant decrease in IGF1R, p-PDK1, and p-AKT levels. …”

Table 1_Coordinated regulation of IGF1R by HIF1α and HIF2α enhances chemoresistance in glioblastoma.docx by Bin Liao (714989)

“…Simultaneous knockout of HIF1α and HIF2α in GBM cells resulted in the highest LDH release and apoptosis rates under hypoxic conditions, accompanied by the most significant decrease in IGF1R, p-PDK1, and p-AKT levels. …”

Inclusion and exclusion table. by Tong-jie Yang (20939652)

“…We systematically evaluated the key findings extracted from the included articles.…”

Table 2_Coordinated regulation of IGF1R by HIF1α and HIF2α enhances chemoresistance in glioblastoma.docx by Bin Liao (714989)

“…Simultaneous knockout of HIF1α and HIF2α in GBM cells resulted in the highest LDH release and apoptosis rates under hypoxic conditions, accompanied by the most significant decrease in IGF1R, p-PDK1, and p-AKT levels. …”

Table 4_Coordinated regulation of IGF1R by HIF1α and HIF2α enhances chemoresistance in glioblastoma.docx by Bin Liao (714989)

“…Simultaneous knockout of HIF1α and HIF2α in GBM cells resulted in the highest LDH release and apoptosis rates under hypoxic conditions, accompanied by the most significant decrease in IGF1R, p-PDK1, and p-AKT levels. …”