Image_1_What can be observed in intervertebral cartilage endplate with aging? An animal model study of excessive axial mechanical loading.PNG by Zhouyang Hu (8410554)

“…MRI analysis revealed significant degenerative changes in the loaded Co8/9 CEP, including decreased signal intensity and the formation of Schmorl’s nodes at 8 and 12 weeks. …”

Table 1_Effects of gut microbiota dysbiosis on the metabolism and pharmacokinetics of losartan in rats: from endogenous to ceftriaxone-induced dysbiosis.docx by Jiaxuan Xia (13808828)

“…</p>Results<p>The results showed that the intestinal flora from SHRs led to a more significant degradation of losartan than that from Wistar Kyoto rats (WKYs) in vitro. …”

Data Sheet 2_Triterpenes in breast cancer: a systematic review of preclinical evidence in rodents.xlsx by Alexandra Prodea (22617710)

“…The toxicity assessment revealed that triterpenes have in general, insignificant or absent toxicity, with only a small number of studies reporting serious side effects such as leukopenia, hepatotoxicity and mortality at specific doses that were reversed in some cases by the use of carriers, which hold the potential to enhance the therapeutic effect of triterpenes while reducing their systemic toxicity.</p>Conclusion<p>We concluded that the current in vivo evidence does not support the clinical translation of triterpenes for the treatment of breast cancer due to methodological and clinical heterogeneity as well as the lack of toxicity data in a significant number of studies. …”

Table 1_Impact of the Yangtze River on Sediment source-to-sink processes in estuarine bays: a study of the Oujiang River Estuary, SE China.docx by Xia Guang (21570056)

“…Our findings revealed a dynamic pattern of sediment distribution, with the predominant clay minerals in the surface sediment of the offshore area being illite, followed by kaolinite and chlorite, with a minor smectite content. Notably, we observed a gradual increase in the proportions of illite and smectite from the upstream to the estuary, while kaolinite decreased accordingly. …”

Data Sheet 1_Triterpenes in breast cancer: a systematic review of preclinical evidence in rodents.pdf by Alexandra Prodea (22617710)

“…The toxicity assessment revealed that triterpenes have in general, insignificant or absent toxicity, with only a small number of studies reporting serious side effects such as leukopenia, hepatotoxicity and mortality at specific doses that were reversed in some cases by the use of carriers, which hold the potential to enhance the therapeutic effect of triterpenes while reducing their systemic toxicity.</p>Conclusion<p>We concluded that the current in vivo evidence does not support the clinical translation of triterpenes for the treatment of breast cancer due to methodological and clinical heterogeneity as well as the lack of toxicity data in a significant number of studies. …”

Data Sheet 1_Prophylactic administration of lecithinized superoxide dismutase for a murine model of oxaliplatin-induced myelosuppression.pdf by Mikako Shimoda (9519493)

“…PC-SOD treatment significantly restored the oxaliplatin-dependent reduction in white blood cell count (day 10). …”

Data Sheet 1_Multimodal MRI reveals distinct hippocampal subregional alterations in de novo Parkinson’s disease across the cognitive spectrum.docx by Chenxi Pan (10211363)

“…The functional connectivity (FC) and gray matter (GM) volume alterations in the anterior, middle, and posterior regions of the left hippocampus were investigated. Moreover, we explored their relationship with cognition.</p>Results<p>Compared to the PD-NC, the PD-SCD group revealed a significantly decreased FC between the left middle hippocampus (HIPm) and right postcentral gyrus (PoCG. …”

Functional predictions and abundance top 15. by Xia Deng (613144)

“…The FUN Guild prediction showed that six groups of plant pathogens and plant saprotrophs changed significantly (<i>P <</i> 0.05), the amount of harmful bacteria in the soil increased while the amount of arbuscular mycorrhizal fungui (AMF) decreased, leading to a continuous cropping obstacle of lavender. …”

Data Sheet 1_The global, regional, and national impact of laryngeal cancer from 1990 to 2021, along with forecasts for 2050: a comprehensive analysis for the Global Burden of Disea... by Tingting Duan (5181482)

“…However, there are significant differences among different countries and regions. …”

DataSheet1_Genetic variants of LRRC8C, OAS2, and CCL25 in the T cell exhaustion-related genes are associated with non-small cell lung cancer survival.doc by Guojun Lu (7169969)

“…Background<p>T cell exhaustion is a state in which T cells become dysfunctional and is associated with a decreased efficacy of immune checkpoint inhibitors. …”

Table1_Genetic variants of LRRC8C, OAS2, and CCL25 in the T cell exhaustion-related genes are associated with non-small cell lung cancer survival.docx by Guojun Lu (7169969)

“…Background<p>T cell exhaustion is a state in which T cells become dysfunctional and is associated with a decreased efficacy of immune checkpoint inhibitors. …”

Data Sheet 1_What regulates decomposition in agroecosystems? Insights from reading the tea leaves.pdf by Marshall D. McDaniel (4341325)

“…No-tillage increased, but perennial cropping decreased, the rate of rooibos tea decomposition (C:N = 50.1). …”

Table 1_The real-world safety of Nivolumab: a pharmacovigilance analysis based on the FDA adverse event reporting system.docx by Yutong Wu (3130584)

“…Notably, we detected several potential safety signals not currently listed in the prescribing information: Malignant neoplasm progression, weight decreased, sepsis myocarditis, encephalitis and hypotension.…”

Data Sheet 1_Cytosolic phospholipase A2 links tau pathology to insulin signaling impairment in Alzheimer’s disease.pdf by Faruk Hossen (20275670)

“…Specifically, we found significant decreases in insulin receptor-α (IR-α) and insulin receptor-β (IR-β) expression, along with increased levels of phospho-insulin receptor substrate 1 at Ser307 [p-IRS-1 (Ser307)] and decreased levels of p-IRS-1 (Tyr895), compared to wild-type (WT) mice. …”

Data Sheet 1_Anti-neoplastic effects of the antipsychotic drug penfluridol in preclinical prostate cancer models.pdf by Arjanneke F. van de Merbel (5809940)

“…</p>Results<p>Penfluridol significantly reduced the viability of a panel of human PCa cells, induced apoptosis by increasing caspase-3/7 levels and decreased the number of PCa stem cells in vitro. …”

Data Sheet 2_Anti-neoplastic effects of the antipsychotic drug penfluridol in preclinical prostate cancer models.docx by Arjanneke F. van de Merbel (5809940)

“…</p>Results<p>Penfluridol significantly reduced the viability of a panel of human PCa cells, induced apoptosis by increasing caspase-3/7 levels and decreased the number of PCa stem cells in vitro. …”

Fasting inhibits glycolysis and migration/invasion in gallbladder cancer via PCBP2/ANGPTL4 signaling by Ying Tao (469347)

“…We found that fasting could inhibit glycolysis and cell migration/invasion in GBC cells and that fasting mimic diets could significantly inhibit GBC cell proliferation in a mouse xenograft model. …”

Data Sheet 2_Heterogeneity in polyamine metabolism dictates prognosis and immune checkpoint blockade response in hepatocellular carcinoma.csv by Jianyan Pan (20681864)

“…In vitro experiments suggested that FIRRE, the gene with the greatest impact on the PAscore, significantly contributed to HCC proliferation and metastasis. …”

Image 4_ZKSCAN3 promotes ovarian cancer cell proliferation by increasing HSPB1 expression.pdf by Qian Ke (9164990)

“…HSPB1 expression is significantly decreased upon suppressing ZKSCAN3 expression. …”

Table 1_ZKSCAN3 promotes ovarian cancer cell proliferation by increasing HSPB1 expression.docx by Qian Ke (9164990)

“…HSPB1 expression is significantly decreased upon suppressing ZKSCAN3 expression. …”