Discovery of Novel [1,2,4]Triazolo[1,5‑<i>a</i>]pyrimidine Derivatives as Novel Potent S‑Phase Kinase-Associated Protein 2 (SKP2) Inhibitors for the Treatment of Cancer by Kaizhao Hu (15670612)

“…Pharmacological inhibition of Skp2 has exhibited promising antitumor activity. Herein, we present the design and optimization of a series of [1,2,4]triazolo[1,5-<i>a</i>]pyrimidine-based small molecules targeting Skp2. …”

Discovery of Novel [1,2,4]Triazolo[1,5‑<i>a</i>]pyrimidine Derivatives as Novel Potent S‑Phase Kinase-Associated Protein 2 (SKP2) Inhibitors for the Treatment of Cancer by Kaizhao Hu (15670612)

“…Pharmacological inhibition of Skp2 has exhibited promising antitumor activity. Herein, we present the design and optimization of a series of [1,2,4]triazolo[1,5-<i>a</i>]pyrimidine-based small molecules targeting Skp2. …”

Discovery of Novel [1,2,4]Triazolo[1,5‑<i>a</i>]pyrimidine Derivatives as Novel Potent S‑Phase Kinase-Associated Protein 2 (SKP2) Inhibitors for the Treatment of Cancer by Kaizhao Hu (15670612)

“…Pharmacological inhibition of Skp2 has exhibited promising antitumor activity. Herein, we present the design and optimization of a series of [1,2,4]triazolo[1,5-<i>a</i>]pyrimidine-based small molecules targeting Skp2. …”

Discovery of Novel [1,2,4]Triazolo[1,5‑<i>a</i>]pyrimidine Derivatives as Novel Potent S‑Phase Kinase-Associated Protein 2 (SKP2) Inhibitors for the Treatment of Cancer by Kaizhao Hu (15670612)

“…Pharmacological inhibition of Skp2 has exhibited promising antitumor activity. Herein, we present the design and optimization of a series of [1,2,4]triazolo[1,5-<i>a</i>]pyrimidine-based small molecules targeting Skp2. …”

Discovery of Novel [1,2,4]Triazolo[1,5‑<i>a</i>]pyrimidine Derivatives as Novel Potent S‑Phase Kinase-Associated Protein 2 (SKP2) Inhibitors for the Treatment of Cancer by Kaizhao Hu (15670612)

“…Pharmacological inhibition of Skp2 has exhibited promising antitumor activity. Herein, we present the design and optimization of a series of [1,2,4]triazolo[1,5-<i>a</i>]pyrimidine-based small molecules targeting Skp2. …”

Results of differential abundance assessment expressed as Log2 Fold Change (Log2FC) for comparison between different taxonomic groups after the intervention. by Adriana Bittencourt Campaner (21175462)

Expression analysis of color-related genes in the hepatopancreas and shell tissues of cherry shrimp (<i>N</i>. <i>davidi</i> var. red) fed with vehicle, astaxanthin alone and in co... by Wei-Wei Hou (3405947)

Phosphorylation of LKB1 and AMPK in 3T3-L1 adipocytes treated with isoarborinol. by Yesenia Arcos-Reyes (22177391)

Supplementary file 1_Investigating the feasibility of machine learning to guide personalized red blood cell (RBC) transfusion: analyzing the heterogeneity of RBC transfusion in sep... by Penglei Yang (8090156)

“…Background<p>This study utilized the causal forest algorithm to explore the heterogeneity of treatment effects of low-dose red blood cell (RBC) transfusion on the 90-day survival rate of sepsis patients with hemoglobin (Hb) levels of 7–9 g/dL to develop personalized transfusion strategies.…”

Primers for qPCR. by Kaitao Zhao (3617825)

“…Transiently or stably knockdown of MRE11, RAD50 or NBS1 in hepatocytes before HBV infection significantly decreased viral markers, including cccDNA, while reconstitution reversed the effect. …”

Antibodies used for western blotting. by Kaitao Zhao (3617825)

“…Transiently or stably knockdown of MRE11, RAD50 or NBS1 in hepatocytes before HBV infection significantly decreased viral markers, including cccDNA, while reconstitution reversed the effect. …”

Target sequences of siRNAs. by Kaitao Zhao (3617825)

“…Transiently or stably knockdown of MRE11, RAD50 or NBS1 in hepatocytes before HBV infection significantly decreased viral markers, including cccDNA, while reconstitution reversed the effect. …”

Plasmids information. by Kaitao Zhao (3617825)

“…Transiently or stably knockdown of MRE11, RAD50 or NBS1 in hepatocytes before HBV infection significantly decreased viral markers, including cccDNA, while reconstitution reversed the effect. …”

Raw data. by Kaitao Zhao (3617825)

“…Transiently or stably knockdown of MRE11, RAD50 or NBS1 in hepatocytes before HBV infection significantly decreased viral markers, including cccDNA, while reconstitution reversed the effect. …”

Graphical abstract regarding program development. by Ana Beato (20489933)

“…<div><p>The stigma surrounding mental health remains a significant barrier to help-seeking and well-being in youth populations. …”

Phases of the intervention program. by Ana Beato (20489933)

“…<div><p>The stigma surrounding mental health remains a significant barrier to help-seeking and well-being in youth populations. …”

Influence of Postsynthetic Ligand Exchange in ZIF‑7 on Gate-Opening Pressure and CO₂/CH₄ Mixture Separation by Lukas W. Bingel (9371686)

“…The field of flexible metal–organic frameworks (MOFs) has garnered significant attention from researchers due to their potential for gas storage and capture applications. …”

Consort diagram. by Ana Beato (20489933)

“…<div><p>The stigma surrounding mental health remains a significant barrier to help-seeking and well-being in youth populations. …”

Influence of Postsynthetic Ligand Exchange in ZIF‑7 on Gate-Opening Pressure and CO₂/CH₄ Mixture Separation by Lukas W. Bingel (9371686)

“…The field of flexible metal–organic frameworks (MOFs) has garnered significant attention from researchers due to their potential for gas storage and capture applications. …”

Characteristics of the sample. by Ana Beato (20489933)

“…<div><p>The stigma surrounding mental health remains a significant barrier to help-seeking and well-being in youth populations. …”