A novel phosphorylated STAT3 inhibitor enhances T cell cytotoxicity against melanoma through inhibition of regulatory T cells by Abou-Ghazal, Mohamed K.

“…We found that the mean percentage of peripheral blood mononuclear cells expressing phosphorylated STAT3 (p-STAT3) was significantly elevated in samples from patients with melanoma brain metastases compared to healthy donors, 16.13 ± 2.48% versus 4.17 ± 1.79%. …”
Get full text
Get full text
Get full text

The protective effects of conditioned media from human mesenchymal stem cells against Methylglyoxal-mediated injury of cultured endothelial cells by Maram Hasan (6672440)

“…Moreover, Ea.hy926 cell viability was significantly reduced by 35% when treated with MGO; while cells treated with MSCs-CM (50%) were protected. …”

Targeting of lactate dehydrogenase C dysregulates the cell cycle and sensitizes breast cancer cells to DNA damage response targeted therapy by Adviti Naik (673163)

“…Silencing LDHC in four breast cancer cell lines significantly increased the presence of giant cells, nuclear aberrations, DNA damage, and apoptosis. …”

Mutational landscape of aggressive cutaneous squamous cell carcinoma by Saade, Rami E.

“…KMT2C mutations were associated with poor outcome and increased bone invasion. Conclusions: The mutational spectrum of cSCC is similar to that of head and neck squamous cell carcinoma and dominated by tumor suppressor genes. …”
Get full text
Get full text
Get full text
Get full text

Metabolomics analyses reveal the crucial role of ERK in regulating metabolic pathways associated with the proliferation of human cutaneous T‐cell lymphoma cells treated with Glabri... by Abdul Q. Khan (14153247)

“…<p dir="ltr">Cutaneous T‐cell lymphomas (CTC) are a heterogeneous group of T‐cell lymphoproliferative malignancies of the skin with limited treatment options, increased resistance and remission. …”

Amniotic stem cells as a source of regenerative medicine to treat female infertility by Aisha Naeem (14157078)

“…Nonetheless, clinical management of some conditions such as dysfunctional endometrium, premature ovarian failure, and ovarian physiological aging still pose significant challenges. Stem cells based therapeutic strategies have a long-standing history to treat many infertility conditions, but ethical restrictions do not allow the broad-scale utilization of adult mesenchymal stromal/stem cells (MSCs). …”

The Anti-Cancer Effect of Strained Photoactivatable Polypyridyl Ruthenium(II) Complexes on Non-Small-Cell Lung Cancer and Triple Negative Breast Cancer Cells by Fayad, Christelle

“…Western blot analysis on MDA-MB-231 cells treated with C3 showed a significant increase in BAX/Bcl2 ratio with no significant effect on Pro-caspase-3 expression. …”
Get full text
Get full text
Get full text

Nox2 Activity Is Required in Obesity-Mediated Alteration of Bone Remodeling by Md Mizanur Rahman (14603354)

“…Furthermore, the in vitro differentiation of bone marrow cells into osteoclasts was significantly increased when using bone marrow cells from WT-HFD mice as compared to KO-HFD mice. …”

Metformin treatment inhibits motility and invasion of glioblastoma cancer cells by Al Hassan, Marwa

“…Furthermore, metformin’s efficiency in inhibiting 2D cell motility and cell invasion in addition to increasing cellular adhesion was also demonstrated in SF268 and U87 cells. …”
Get full text
Get full text
Get full text
Get full text

The anti-cancer effect of series of strained photoactivatable Ru(II) polypyridyl complexes on non-small-cell lung cancer and triple negative breast cancer cells by Fayad, Christelle

“…It also significantly increased Bax/Bcl2 ratio and PERK levels without affecting caspase-3 expression. …”
Get full text
Get full text
Get full text
Get full text

Squamous Cell Carcinomas of the Head and Neck Cancer Response to Programmed Cell Death Protein-1 Targeting and Differential Expression of Immunological Markers: A Case Report by Maysaloun Merhi (4246147)

“…The NY-ESO-1-specific T cells response of the patient was found to be increased after the third and the fifth (**p = 0.002) cycles of treatment but had a significant decline after progression (**p = 0.0028). …”

Molecular Mechanisms of Adiponectin-Induced Attenuation of Mechanical Stretch-Mediated Vascular Remodeling by Crystal M. Ghantous (14571292)

“…Mechanical stretch significantly increased p-ERK1/2 after 10 minutes, whereas APN significantly reduced stretch-induced ERK1/2 phosphorylation. …”

Antioxidant Activity Mediates Pirfenidone Antifibrotic Effects in Human Pulmonary Vascular Smooth Muscle Cells Exposed to Sera of Idiopathic Pulmonary Fibrosis Patients by Alessandro Giuseppe Fois (2901365)

“…IPF sera-induced cellular effects were significantly blunted in cells exposed to the NADPH oxidase inhibitor diphenyleneiodonium (DPI) proving the causative role of ROS and suggesting their potential cellular source. …”

Proteome analysis of Candida albicans cell wall mutants. (c2011) by Koussa, Joseph Wissam

Get full text
Get full text

Transferrin‑modifed liposomes triggered with ultrasound to treat HeLa cells by AlSawaftah, Nour Majdi

“…Calcein uptake by HeLa cells was found to be significantly higher with the Tf-PEG liposomes compared to the non-targeted control liposomes. …”
Get full text

Experimental and numerical study of different metal contacts for perovskite solar cells by Mohammad Istiaque Hossain (17944964)

“…The computational analysis confirms that screening of suitable metal back contact is necessary to increase device performance and stability significantly.…”

A photoactivatable chemotherapeutic Ru(II) complex bearing bathocuproine ligand efficiently induces cell death in human malignant melanoma cells through a multi-mechanistic pathway by Elias, Maria George

“…A significant increase in ROS production and DNA damage was also observed. …”
Get full text
Get full text
Get full text
Get full text

Stimulation of sphingosine 1-phosphate signaling as an alveolar cell survival strategy in emphysema by Diab, Khalil J.

“…Rationale: Vascular endothelial growth factor receptor (VEGFR) inhibition increases ceramides in lung structural cells of the alveolus, initiating apoptosis and alveolar destruction morphologically resembling emphysema. …”
Get full text
Get full text
Get full text
Get full text

Altered regulation of cell migration in IRF6-mutated orofacial cleft patients-derived primary cells reveals a novel role of RhoGTPases in cleft/lip palate development by Al Saneh, Mounir

“…The aim is to look for significant differences in the behaviour of the CL/P patient-derived cells in vitro when compared to control cells from the healthy donor through the study of different mechanisms, including cell proliferation, cell migration and adhesion. …”
Get full text
Get full text
Get full text

Investigating The Efficacy of Ruxolitinib and CHIR-99021 in Targeting Pediatric Neuroblastoma Stem Cells by Al Sayyed, Fatima

“…Western blot analysis showed significant decrease in stem cell markers SOX-2 and Oct-4, and tumorigenic protein HMGA1, whereas it showed significant increase in apoptotic markers cleaved PARP and cleaved caspase-3. …”
Get full text
Get full text
Get full text