Data Sheet 1_Bifidobacterium depletion promotes goiter via gut-thyroid axis: evidence from Mendelian randomization and experimental validation.xls by Wenyong Liao (21669332)

“…In goiter rats, 16S rRNA sequencing revealed eight differentially abundant microbial taxa including significantly reduced B. bifidum, accompanied by: (1) impairment of two butyrate synthesis pathways, (2) decreased levels of six SCFAs (including butyrate), (3) impaired thyroid iodine uptake, (4) downregulated NIS expression, and (5) thyroid dysfunction [reduced triiodothyronine (T3), thyroxine (T4), free T3 (FT3), free T4 (FT4) with elevated thyroid-stimulating hormone (TSH)] - all measurements showing statistical significance (p < 0.05).…”

Table 1_Chicory supplementation improves growth performance in juvenile ostriches potentially by attenuating enteritis.xlsx by Meng Li (79487)

“…The diet with the CC supplementation significantly increased the abundance of Phascolactobacteria (linear discriminant analysis; LDA >4) and Bacteroidota (26.7% vs. 17.7%, respectively) as well as decreased the enrichment of Clostridium (5.0% vs. 9.1%, respectively) in the ostrich ilea compared to the diet without CC. …”

Image 1_Myo-inositol improves developmental competence and reduces oxidative stress in porcine parthenogenetic embryos.tif by Ali Jawad (1728757)

“…Myo-Ins supplementation also decreased the rate of apoptosis and the apoptotic index in the treatment groups. …”

Table 1_DNase I alleviates renal inflammatory injury in MRL/lpr mice by inhibiting NETs formation.docx by Manling Zhang (566460)

“…RNA-seq analysis revealed that the neutrophil and T cell activation and chemotaxis pathways were suppressed, and the infiltration of cytotoxic immune cells in the kidneys was decreased in the DNase I-treated group compared to MRL/lpr mice. …”

Table 7_Genome-wide association study of seedling–plant resistance to stripe rust in bread wheat (Triticum aestivum L.) genotypes.xlsx by Genet Atsbeha (17595417)

“…<p>Fungal diseases, such as stripe rust, are major bottlenecks in Ethiopian wheat production. They can significantly reduce yields and impact regional food security. …”

Data Sheet 1_Chicory supplementation improves growth performance in juvenile ostriches potentially by attenuating enteritis.docx by Meng Li (79487)

“…The diet with the CC supplementation significantly increased the abundance of Phascolactobacteria (linear discriminant analysis; LDA >4) and Bacteroidota (26.7% vs. 17.7%, respectively) as well as decreased the enrichment of Clostridium (5.0% vs. 9.1%, respectively) in the ostrich ilea compared to the diet without CC. …”

Table 1_Associations between systemic inflammatory indices and the risk of renal function decline in patients with type 2 diabetes mellitus: a retrospective cohort study.docx by Zhi Shang (4849129)

“…</p>Conclusion<p>A significantly positive association was shown between systemic inflammatory indices and the risk of renal function decline in T2DM patients. …”

Table 2_Prognostic value of platelet to lymphocyte ratio (PLR) in breast cancer patients receiving neoadjuvant therapy: a systematic review and meta-analysis.docx by Ziqian Zhao (9518348)

“…</p>Results<p>Twenty-four studies involving 7,557 BC patients receiving NACT were included. Elevated PLR was significantly associated with reduced pCR rates (HR = 1.51; 95% CI: 1.24–1.84; p < 0.0001; I² = 70%), shorter OS (HR = 1.64; 95% CI: 1.27–2.11; p = 0.0002; I² = 0%), and decreased DFS (HR = 2.29; 95% CI: 1.54–3.39; p < 0.0001; I² = 44%). …”

Table 1_NLRP3 deficiency aggravated DNFB-induced chronic itch by enhancing type 2 immunity IL-4/TSLP-TRPA1 axis in mice.docx by Si-Ting Huang (5591432)

“…Inhibition of TRPA1 or administration of recombinant IL-18 significantly reduced DNFB-induced itch behavior in Nlrp3-/- mice. …”

Data Sheet 2_Impact of digital health on Type 2 diabetes management: a randomised controlled trial of the ‘TreC Diabete’ platform (TELEMECHRON Study).docx by Alexia Giovanazzi (16816139)

“…At 12 months, the median change in HbA1c levels did not differ significantly between groups. Regarding app usage, data entries decreased significantly from the first quarter to the second quarter but subsequently stabilised (p = 0.001). …”

Table 13_Genome-wide association study of seedling–plant resistance to stripe rust in bread wheat (Triticum aestivum L.) genotypes.xlsx by Genet Atsbeha (17595417)

“…<p>Fungal diseases, such as stripe rust, are major bottlenecks in Ethiopian wheat production. They can significantly reduce yields and impact regional food security. …”

Table 1_Genome-wide association study of seedling–plant resistance to stripe rust in bread wheat (Triticum aestivum L.) genotypes.doc by Genet Atsbeha (17595417)

“…<p>Fungal diseases, such as stripe rust, are major bottlenecks in Ethiopian wheat production. They can significantly reduce yields and impact regional food security. …”

Table 1_Prognostic value of platelet to lymphocyte ratio (PLR) in breast cancer patients receiving neoadjuvant therapy: a systematic review and meta-analysis.docx by Ziqian Zhao (9518348)

“…</p>Results<p>Twenty-four studies involving 7,557 BC patients receiving NACT were included. Elevated PLR was significantly associated with reduced pCR rates (HR = 1.51; 95% CI: 1.24–1.84; p < 0.0001; I² = 70%), shorter OS (HR = 1.64; 95% CI: 1.27–2.11; p = 0.0002; I² = 0%), and decreased DFS (HR = 2.29; 95% CI: 1.54–3.39; p < 0.0001; I² = 44%). …”

Data Sheet 1_Assessment of the effect of social media use on medical students’ academic performance: cross-sectional study from Jordan.pdf by Hana Taha (4747014)

“…GPA was significantly associated with more time spent on social media (OR: 0.476; 95%CI: 0.278–0.813; p = 0.022). …”

Passive mapping of hand motor cortex across altered states of consciousness by Yusheng Tong (6183350)

“…The sensitivity based on HGB average power at short-latency period decreased from 100% in awake stage to 72.83%±12.95%, 48.11%±15.95%, and 21.12%±5.70% across LOC stages. …”

Image 2_Global, regional, and national burden of ischemic stroke in older adults (≥60 years) from 1990 to 2021 and projections to 2030.jpeg by Shuting Hua (21264785)

“…</p>Conclusion<p>The global burden of ischemic stroke has significantly decreased, particularly in high-SDI regions with abundant healthcare resources. …”

Data Sheet 1_Global, regional, and national burden of ischemic heart disease attributed to non-optimal temperature, 1990–2021: an age-period-cohort analysis of the global burden of... by Xiaoqing Xia (14607269)

“…Background<p>In recent years, non-optimal temperature has significantly impacted global health including ischemic heart disease (IHD).…”

Table 12_Genome-wide association study of seedling–plant resistance to stripe rust in bread wheat (Triticum aestivum L.) genotypes.xlsx by Genet Atsbeha (17595417)

“…<p>Fungal diseases, such as stripe rust, are major bottlenecks in Ethiopian wheat production. They can significantly reduce yields and impact regional food security. …”

Supplementary file 1_Bibliometrics-guided cyberpharmacology and transcriptomics for multidimensional analysis of the antihepatic fibrosis mechanism of kaempferol.docx by Jiali Liu (327739)

“…Additionally, it impacted the dysregulation of lipid metabolism and inflammatory response pathways, significantly inhibited hepatic stellate cell (HSC) activation, and reduced ECM accumulation.…”

Data Sheet 1_Study of pain perception under negative emotions and its large-scale brain network dynamics in adolescents with non-suicidal self-injury.zip by Yang Zhou (65942)

“…In contrast, the occurrence frequency, coverage of microstate B, and transition probabilities from microstates C/D→B were significantly lower in the MDD group than in the HC group.…”