cGAS promotes DNA damage induced apoptosis of HPV positive cells. by Elona Gusho (4688170)

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BA attenuated the decrease in the integrity and increase in the permeability of the epithelial barrier injury induced by LPS in Caco2 cell monolayers. by Luqiong Liu (11537092)

HPV positive cells lacking cGAS display lower levels of γH2AX and cleaved caspases 3/7. by Elona Gusho (4688170)

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Etoposide does not cause an early interferon response in primary or HPV positive keratinocytes. by Elona Gusho (4688170)

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HPV positive cells synthesize 2’3’ cGAMP. by Elona Gusho (4688170)

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DNA damage induces cGAS expression in HPV positive cells while IFN has no effect. by Elona Gusho (4688170)

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Complete western blots for pSTING post cGAMP treatment. by Elona Gusho (4688170)

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cGAS-STING canonical pathway is active and responsive in high risk HPV positive keratinocytes. by Elona Gusho (4688170)

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Host population bottlenecks decrease microbiome diversity. by Michael Ørsted (5926028)

Y-27632 collaborated with BA to attenuate the increase in the integrity and decrease in the permeability of epithelial barrier injury induced by LPS in Caco2 monolayers. by Luqiong Liu (11537092)

“…<p>(<b>A)</b> Y-27632 collaborated with BA to attenuate the effect of LPS on TEER in Caco2 cells on days 1–22. (<b>B)</b> Y-27632 collaborated with BA to attenuate the effect of LPS on TEER in Caco2 cells on day 22. …”

Y-27632 synergized with BA to alleviate the decrease in the expression of and abnormal localization of ZO-1 and Occludin in LPS-induced Caco2 cells. by Luqiong Liu (11537092)

STING expression specifically stabilizes nsP1. by L. G. Webb (9525495)

The role of cGAS in innate antiviral responses against MeV. by Hiroki Sato (105731)

The role of cGAS in innate antiviral responses against MeV. by Hiroki Sato (105731)

“…(C) MCF7 cells were transfected with siRNA for the negative control (NC), MAVS, cGAS, or both. Left: immunoblot of the cell lysate. …”

PCV Rep suppresses cGAS activation by self-DNA. by Hongyan Yin (5066285)

“…<p>(A, B and C) iPAMs were transfected with increasing doses of PCV2d Rep for 24 h. Cells were stimulated with BPTES at a concentration of 10 uM. …”

PRV US1 inhibits cGAS-mediated production of downstream ISGs. by Weiyu Qu (16556638)

Peptides derived from US1 bind to cGAS and inhibit its activation. by Weiyu Qu (16556638)

“…In a mixture of 2.5 μM ISD45, peptide AB and cGAS, proteins and peptides were increased in a molar ratio of 1:0 to 1:32, followed by EMSA. …”

The effect of HA digestion and HA replenishment alone or with CS on barrier function measured by TEER. by Charlotte J. van Ginkel (20790466)

“…PS decreased TEER. (C) Different treatments (treatment groups n = 8)with HA and/or CS did not affect TEER recovery after PS treatment, full recovery was seen in all groups after 24 hours. …”

Alpha-herpesvirus US1 protein inhibits cGAS-mediated IFN-β induction. by Weiyu Qu (16556638)

“…<b>(L)</b> Detection of IFN-β promoter activation in HEK-293T cells was performed 24 hours after transfection with the IFN-β-Luc reporter plasmid, PRV or HSV-1 US1 protein expression plasmids, or an empty vector, with or without co-transfection of cGAS and STING, using the dual-luciferase reporter assay. ns, not significant; ***<i><i>P</i></i> < 0.0001. …”

PCV2d Rep disrupts cGAS oligomerization and phase separation. by Hongyan Yin (5066285)

“…(E) Immunoblotting assay for cGAS complexes incubated with cross-linker between recombinant pcGAS full length and increasing doses of PCV2d Rep proteins. …”