The second stage regression result of the RDD. by Liya Zheng (4792533)

Subjects:

Table 1_High cGAS-STING expression associates with improved efficacy of neoadjuvant chemo-immunotherapy in head and neck squamous cell carcinoma.docx by Miao Wang (248377)

“…Tumor cells with increased expression of CGAS or STING1 showed enhanced interactions with T cells.…”

Manganese facilitated cGAS-STING-IFNI pathway activation induced by ionizing radiation in glioma cells by Yuping He (808458)

“…Nevertheless, hypoxia significantly inhibited the radiation-induced dose-dependent activation of cGAS-STING-IFNI pathway. …”

RNA and DNA viruses that cause downregulation of mitochondrial biogenesis induce mtDNA-priming IFN-β production. by Hiroki Sato (105731)

MeV infection induces downregulation of mitochondrial biogenesis. by Hiroki Sato (105731)

Effect of knockdown of Mfn1 or PGC-1α. by Hiroki Sato (105731)

The role of Mfn1 in the downregulation of mitochondrial biogenesis in the mtDNA-priming antiviral response. by Hiroki Sato (105731)

RNA and DNA viruses that cause downregulation of mitochondrial biogenesis induce mitochondrial hyperfusion. by Hiroki Sato (105731)

MeV infection induces downregulation of mitochondrial biogenesis and hyperfusion of mitochondria. by Hiroki Sato (105731)

MeV infection induces mitochondrial hyperfusion. by Hiroki Sato (105731)

Image 1_Impact of MEK inhibition on T-cell infiltration and function after radiotherapy in KRAS-mutant lung cancer.tif by Yawen Zheng (6901787)

“…This combination also increased DNA damage and apoptosis in KRAS-mutant lung cancer cell lines, triggering the cGAS-STING pathway. …”

Data Sheet 1_Impact of MEK inhibition on T-cell infiltration and function after radiotherapy in KRAS-mutant lung cancer.pdf by Yawen Zheng (6901787)

“…This combination also increased DNA damage and apoptosis in KRAS-mutant lung cancer cell lines, triggering the cGAS-STING pathway. …”

Table 1_Impact of MEK inhibition on T-cell infiltration and function after radiotherapy in KRAS-mutant lung cancer.docx by Yawen Zheng (6901787)

“…This combination also increased DNA damage and apoptosis in KRAS-mutant lung cancer cell lines, triggering the cGAS-STING pathway. …”

DataSheet1_Capsaicin suppresses ciliary function, while inducing permeability in bronchial epithelial cell cultures of COPD patients.docx by Halil Ibrahim Toy (10533263)

“…Formoterol significantly prevented decreases in CBF induced by capsaicin. …”

Image_3_cGAS deficiency enhances inflammasome activation in macrophages and inflammatory pathology in pristane-induced lupus.jpeg by Sarinya Kumpunya (832534)

“…The dsDNA level, but not mitochondrial DNA, increased dramatically in pristane-injected Cgas-/- mice suggesting the dsDNA could be a ligand activating inflammasomes. …”

Image_1_cGAS deficiency enhances inflammasome activation in macrophages and inflammatory pathology in pristane-induced lupus.jpeg by Sarinya Kumpunya (832534)

“…The dsDNA level, but not mitochondrial DNA, increased dramatically in pristane-injected Cgas-/- mice suggesting the dsDNA could be a ligand activating inflammasomes. …”

Image_2_cGAS deficiency enhances inflammasome activation in macrophages and inflammatory pathology in pristane-induced lupus.jpeg by Sarinya Kumpunya (832534)

“…The dsDNA level, but not mitochondrial DNA, increased dramatically in pristane-injected Cgas-/- mice suggesting the dsDNA could be a ligand activating inflammasomes. …”

Image_4_cGAS deficiency enhances inflammasome activation in macrophages and inflammatory pathology in pristane-induced lupus.jpeg by Sarinya Kumpunya (832534)

“…The dsDNA level, but not mitochondrial DNA, increased dramatically in pristane-injected Cgas-/- mice suggesting the dsDNA could be a ligand activating inflammasomes. …”

The effect of I215L and H171R on IFN-β-Luc activity induced by cGAS-STING. by Xiaohong Liu (50816)

“…<p>(<b>A)</b> HEK293T cells were transfected with an IFN-β-Luc reporter, a Renilla-TK reporter, and plasmids expressing HA-cGAS and HA-STING, together with increasing amounts (100 ng, 200 ng, 400 ng) of a plasmid expressing Flag-I215L or Flag-H117R. …”

Image_2_Biodegradable nanoparticles induce cGAS/STING-dependent reprogramming of myeloid cells to promote tumor immunotherapy.tif by Joseph R. Podojil (12050717)

“…The present studies describe a novel use for ONP-302, employing an altered dosing scheme to reprogram myeloid cells resulting in significant enhancement of tumor immunity. ONP-302 infusion decreased tumor growth via the activation of the cGAS/STING pathway within myeloid cells, and subsequently increased NK cell activation via an IL-15-dependent mechanism. …”