Table1_Development of a risk model to predict prognosis in breast cancer based on cGAS-STING-related genes.docx by Chen Chen (6544)

“…<p>Background: Breast cancer (BRCA) is regarded as a lethal and aggressive cancer with increasing morbidity and mortality worldwide. cGAS-STING signaling regulates the crosstalk between tumor cells and immune cells in the tumor microenvironment (TME), emerging as an important DNA-damage mechanism. …”

Table_1_A Bibliometric Analysis of the Innate Immune DNA Sensing cGAS-STING Pathway from 2013 to 2021.docx by Xuan Shi (739853)

“…Before 2016, the publication trend was increasing steadily, but there was a significant increase after 2016. …”

<i>Leptospira interrogans</i> from Okinawa induces epithelial barrier disruption with different kinetics. by Tetsuya Kakita (4922584)

Data acquired from testing the effect of PAR1 inhibitors on Plasmodium falciparum-induced loss of endothelial cell barrier function by Janet Storm (8266991)

“…The authors used a co-culture of primary human brain microvascular endothelial cells (HBMEC) with <i>Plasmodium falciparum</i> material, recombinant PfEMP1 or lysates from infected erythrocytes (IE), and measured barrier function by Trans Endothelial Electrical Resistance (TEER). A selection of Protease-Activated Receptor-1 (PAR1) inhibitors was tested for their ability to reverse the <i>P. falciparum</i> and thrombin induced decrease in barrier function.…”

Image 1_Epimedium brevicornu Maxim. extract activates natural killer cells against hepatocellular carcinoma via the cGAS-STING pathway.tif by Lu Liu (171341)

“…Mechanistic studies revealed that EPE promoted IFN-β release in NK cells, significantly increased the phosphorylation levels of STING and IRF3. …”

Additional file 1 of ACOX2 destabilizes the MRE11-RAD50-NBS1 complex and boosts anticancer immunity via the cGAS-STING pathway in clear cell renal cell carcinoma by Shiqi Ye (13957986)

“…Scale bar: 10 μm. E Immunoblotting of cGAS-STING pathway markers in the indicated 769-P cells. …”

Image_1_The cGAS/STING–TBK1–IRF Regulatory Axis Orchestrates a Primitive Interferon-Like Antiviral Mechanism in Oyster.jpeg by Xue Qiao (1409857)

“…In the present study, the CgIFNLP protein in hemocytes was observed to increase after Poly (I:C) stimulation. After CgIFNLP was knocked down by RNAi, the mRNA expression of IFN-stimulated genes (CgISGs) was significantly inhibited. …”

Study on the expression of mRNA related to biofilm formation of <i>C. albicans</i> by CSR extract (100 μg/mL). by Xuxi Cheng (22453447)

DataSheet_1_The cGAS/STING–TBK1–IRF Regulatory Axis Orchestrates a Primitive Interferon-Like Antiviral Mechanism in Oyster.doc by Xue Qiao (1409857)

“…In the present study, the CgIFNLP protein in hemocytes was observed to increase after Poly (I:C) stimulation. After CgIFNLP was knocked down by RNAi, the mRNA expression of IFN-stimulated genes (CgISGs) was significantly inhibited. …”

Electrolyte Dependence of Li⁺ Transport Mechanisms in Small Molecule Solvents from Classical Molecular Dynamics by Emily Crabb (8486340)

Subjects:

HPV16 virion infection does not activate cellular responses to dsDNA. by Brittany L. Uhlorn (9707932)

Image_1_Leishmania kinetoplast DNA contributes to parasite burden in infected macrophages: Critical role of the cGAS-STING-TBK1 signaling pathway in macrophage parasitemia.pdf by Ismail Cem Yilmaz (14043801)

“…Parasite proliferation was significantly hindered in cGAS- STING- and TBK-1 knockout THP-1 macrophages when compared to wild type cells. …”

Fig 4 - by Zhen Chen (129176)

Presentation_1_Oxidative DNA Damage Accelerates Skin Inflammation in Pristane-Induced Lupus Model.PPTX by Gantsetseg Tumurkhuu (22786)

“…Use of the STING inhibitor, H151, reduced both basal and cGAMP-driven increases, indicating that OGG1 regulates Ifnb expression through the cGAS-STING pathway. …”

PARP1-cGAS-NF-κB pathway of proinflammatory macrophage activation by extracellular vesicles released during <i>Trypanosoma cruzi</i> infection and Chagas disease by Subhadip Choudhuri (8741193)

“…Inhibition studies suggested that DNA-sensing innate immune receptors (cGAS>>TLR9) synergized with PARP1 in signaling the NFκB activation, and inhibition of PARP1 and cGAS resulted in >80% inhibition of TEv-induced NFκB activity. …”

DataSheet_1_Association Study Between Methylation in the Promoter Regions of cGAS, MAVS, and TRAF3 Genes and the Risk of Cervical Precancerous Lesions and Cervical Cancer in a Sout... by Shiqi Huang (4640158)

“…The promoter methylation status genes were detected from the bisulfite-treated DNA by the bisulfite sequencing PCR (BSP) technique, which was carried out using MethPrimer. The cGAS, MAVS, and TRAF3 promoter methylation levels in CPL (CPL_cGAS = 35.40%, CPL_MAVS = 24.26%, and CPL_TRAF3 = 96.76%) were significantly higher than those in the control (Control_cGAS = 31.87%, Control_MAVS = 21.16%, and Control_TRAF3 = 96.26%, P_cGAS< 0.001, P_MAVS< 0.001, and P_TRAF3 = 0.001); however, there was no significant differences between the CC and control. …”

S1 File - by Luqiong Liu (11537092)

“…Compared with LPS treatment alone, BA significantly mitigated the reduction in the TEER, decreased FD-4 flux permeability, increased the mRNA expression of ZO-1 and Occludin, and normalized the distribution of ZO-1 and Occludin in Caco2 cells. …”

Experimental treatments and groups. by Luqiong Liu (11537092)

“…Compared with LPS treatment alone, BA significantly mitigated the reduction in the TEER, decreased FD-4 flux permeability, increased the mRNA expression of ZO-1 and Occludin, and normalized the distribution of ZO-1 and Occludin in Caco2 cells. …”

Primers for RT-qPCR. by Luqiong Liu (11537092)

“…Compared with LPS treatment alone, BA significantly mitigated the reduction in the TEER, decreased FD-4 flux permeability, increased the mRNA expression of ZO-1 and Occludin, and normalized the distribution of ZO-1 and Occludin in Caco2 cells. …”

Modeling of Microplastics Migration in Soil and Groundwater: Insights into Dispersion and Particle Property Effects by Yaqiang Wei (11230938)

“…Intriguingly, <i>v</i>_maxp of MPs exhibited a nonlinear relationship with MPs’ sizes smaller than 20 μm reaching the highest value (=1.64 × 10^–5 m/s) at a particle size of 8 μm, while a decreasing trend was identified for particle sizes ranging from 20 to 100 μm because of the hindered effect by porous media and the weaker effect of the drag force. …”