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421
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12/15-Lipoxygenase-Derived Lipid Metabolites Induce Retinal Endothelial Cell Barrier Dysfunction: Contribution of NADPH Oxidase
Published 2013“…VEGF-R2 inhibitor reduced the permeability effect of 12-HETE. Treatment of REC with HETE also increased ROS generation and expression of NOX2 and pVEGF-R2 and decreased pSHP1 expression. …”
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423
BCL-2 Inhibitor Venetoclax Induces Autophagy-Associated Cell Death, Cell Cycle Arrest, and Apoptosis in Human Breast Cancer Cells
Published 2020“…This effect was associated with a significant increase in the percentage of apoptotic MDA-MB-231 cells and in the expression of the apoptotic genes, caspase 3, caspase 7, and BAX, with inhibition of antiapoptotic gene, BCL-2 levels. …”
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424
Delineating the molecular mechanisms of hippocampal neurotoxicity induced by chronic administration of synthetic cannabinoid AB-FUBINACA in mice
Published 2024“…Chronic use of synthetic cannabinoids (SCs) has been associated with cognitive and behavioural deficits and an increased risk of neuropsychiatric disorders. The underlying molecular and cellular mechanisms of the neurotoxic effects of long-term use of SCs have not been well investigated in the literature. …”
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425
Board composition, CEO turnover and firm value
Published 2016“…This paper tests the effect of an exogenous shock, the Sarbanes-Oxley Act (SOX) of 2002, on the structure of corporate boards and their efficiency as a monitoring mechanism. …”
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426
Job insecurity
Published 2013“…No significant relationship was found between job insecurity and peer trust. …”
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427
Delineating the molecular mechanisms of hippocampal neurotoxicity induced by chronic administration of synthetic cannabinoid AB-FUBINACA in mice
Published 2024“…<p dir="ltr">Chronic use of synthetic <u>cannabinoids</u> (SCs) has been associated with cognitive and behavioural deficits and an increased risk of neuropsychiatric disorders. The underlying molecular and cellular mechanisms of the neurotoxic effects of long-term use of SCs have not been well investigated in the literature. …”
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428
Assessment of Disinfection By-Product Formation in Polymeric Pipe Distribution Systems
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429
Efficiency of commercial banks in Lebanon
Published 2008“…The stochastic production and cost function estimates show that bank level inefficiency effects decreases with time and increases with number of branches, employees per branch, and ratio of staff to operating expenses.…”
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430
A photoactivatable chemotherapeutic Ru(II) complex bearing bathocuproine ligand efficiently induces cell death in human malignant melanoma cells through a multi-mechanistic pathway
Published 2021“…A significant increase in ROS production and DNA damage was also observed. …”
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431
Bevacizumab Improves Pathologic Response and Protects Against Hepatic Injury in Patients Treated With Oxaliplatin-Based Chemotherapy for Colorectal Liver Metastases
Published 2007“…The current study evaluated the effect of bevacizumab added to fluoropyrimidine-plus-oxaliplatin (5FU/OX) chemotherapy for colorectal liver metastases (CLM) on the pathologic response and nontumorous liver histology. …”
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432
Walking around the preferred speed: examination of metabolic, perceptual, spatiotemporal and stability parameters
Published 2024“…Results indicated a significant main effect of speed on all studied variables. …”
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433
Co-occurrence of antibiotic and metal resistance in long-term sewage sludge-amended soils: influence of application rates and pedo-climatic conditions
Published 2022“…<p dir="ltr">Urban sewage sludge (USS) is increasingly being used as an alternative organic amendment in agriculture. …”
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434
Tryptophanyl-tRNA synthetase-1 (WARS-1) depletion and high tryptophan concentration lead to genomic instability in Caenorhabditis elegans
Published 2024“…Our result demonstrates that exposing C. elegans to a high tryptophan dosage leads to DNA damage checkpoint activation and a significant increase in the tryptophan metabolites. …”
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435
Double diffusive mixed convection and entropy generation analysis of NEPCM-water mixture in a π-shaped cavity
Published 2025“…Results demonstrate that Reynolds and Richardson numbers significantly enhance heat and mass transfer (up to 204 % increase in Nusselt number), while magnetic fields substantially suppress convective transport (60.5 % reduction in Nusselt number). …”
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436
Sustainable urban development strategies to enhance outdoor thermal comfort and promote walkability in the United Arab Emirates
Published 2021“…Moreover, individuals can walk less than 10 min in summertime before the feel very uncomfortable. while this duration significantly increases if the street is shaded. The result if simulations shows that street orientation and H/W aspect ratio can contribute to enhancement of 2 °C. …”
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437
A lipidomic screen of hyperglycemia-treated HRECs links 12/15-Lipoxygenase to microvascular dysfunction during diabetic retinopathy via NADPH oxidase
Published 2015“…The permeability effect of 12-HETE was significantly reduced in NOX2<sup>−/−</sup> mice compared with the WT mice. …”
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438
The Interplay of E-commerce, Resilience and Exports in the Context of COVID-19
Published 2022“…Furthermore, held as a constant, firm size demonstrates a significant and positive effect on direct and indirect exports. …”
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439
The Foreign Direct Investment and Trade Connection Between China and the Gulf Cooperation Council Countries
Published 2025“…The findings show that cumulative FDI Granger-causes an increase in trade volume. Specifically, each one-million-dollar increase in FDI is associated with an $88,269 rise in Chinese exports to the GCC countries and a $64,760 increase in imports from the GCC. …”
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440
Formation of Trihalomethanes during Seawater Chlorination
Published 2010“…Chlorination of seawater has shown significant increase in total THMs (TTHMs) and in bromoform concentrations. …”