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Microwave hyperthermia enhances radiosensitization by decreasing DNA repair efficiency and inducing oxidative stress in PC3 prostatic adenocarcinoma cells
Published 2024“…Protein expression levels of DNA-PKcs, ATM, ATR, and P53/P21 signaling pathways significantly decreased in RT + MW-HT groups.</p> <p>MW-HT + RT treatment significantly inhibited DNA damage repair by downregulating DNA-PKcs, ATM, ATR, and P53/P21 signaling pathways, leading to increased ROS levels, aggravate DNA damage, apoptosis, and necrosis in PC3 cells, a well-established model of CRPC.…”
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Mitochondrial ROS is increased when cells are exposed to DHA.
Published 2022“…<p>(A) HepG3 cells were dosed with 7 mM DHA for 24 and 48 h and imaged to evaluate mitochondrial ROS; scale bars 25 μm. (B) A significant increase in fluorescent intensity can be observed at 24 and 48h DHA exposure cells compared to the control. …”
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Data_Sheet_1_ROS scavengers decrease γH2ax spots in motor neuronal nuclei of ALS model mice in vitro.PDF
Published 2022“…Furthermore, we found a significantly altered expression of several antioxidant molecules in the spinal cord of Wobbler mice, suggesting a deficit in ROS detoxification mechanisms. …”
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Data_Sheet_1_SKIP Silencing Decreased Disease Resistance Against Botrytis cinerea and Pseudomonas syringae pv. tomato DC3000 in Tomato.pdf
Published 2020“…VIGS-mediated SlSKIP1b silencing led to increased accumulation of reactive oxygen species (ROS), along with the decreased expression of defense-related genes (DRGs) after pathogen infection, suggesting that it reduced B. cinerea and Pst DC3000 resistance. …”
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Data_Sheet_1_Inhibition of Murine Breast Cancer Metastases by Hydrophilic As4S4 Nanoparticles Is Associated With Decreased ROS and HIF-1α Downregulation.pdf
Published 2019“…It was shown that e-As<sub>4</sub>S<sub>4</sub> was much more cytotoxic than r-As<sub>4</sub>S<sub>4</sub>, strongly inhibiting the proliferation of the cells and scavenging intracellular reactive oxygen species (ROS). The oral administration of e-As<sub>4</sub>S<sub>4</sub> significantly increased the accumulation of arsenic in the tumor tissue and eliminated ROS in tumor tissues. …”
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