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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
منشور في 2019"…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …"
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Daucus carota pentane-based fractions arrest the cell cycle and increase apoptosis in MDA-MB-231 breast cancer cells
منشور في 2014"…The increase in apoptosis in response to treatment was also apparent in the increase in BAX and the decrease in Bcl-2 levels as well as the proteolytic cleavage of both caspase-3 and PARP as revealed by Western blot. …"
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Growth hormone treatment modulates active ghrelin levels in rats
منشور في 2014"…Genotropin treatment caused a dose dependent decrease in active ghrelin concentration in stomach, kidney and pancreas with a concomitant increase in plasma, and reaching significance at 20 and 100 µg/rat/day doses. …"
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Renewable Energy, Coal as a Baseload Power Source, and Greenhouse Gas Emissions: Evidence from U.S. State-Level Data
منشور في 2017"…After accounting for the role of coal as a baseload power source, an increase in the share of renewable energy is estimated to mitigate N2O emissions at the U.S. state level only if states individually decrease their share of coal use to levels below 41.47%. …"
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EEG-Based Semantic Vigilance Level Classification Using Directed Connectivity Patterns and Graph Theory Analysis
منشور في 2020"…Behaviorally, all subjects demonstrated vigilance decrement as reflected by the significant increase in response time and reduced accuracy. …"
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Intravenous administration of gold nanoparticles in rats exhibit alterations in sphingomyelins, bile acids, sphingolipids, and cholesterol esters levels
منشور في 2024"…Results indicate that AuNPs treatment significantly impacted several metabolic pathways. Notably, there was an increase in sphingomyelin (SM 34:2) levels (estimate 0.23, <i>p</i> ≤ 0.001), which are critical for cell membrane structure and signalling. …"
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Neoadjuvant Chemotherapy Alters Neuropilin-1, PlGF, and SNAI1 Expression Levels and Predicts Breast Cancer Patients Response
منشور في 2019"…In addition, NRP-1 knockdown in MDA-MB-231 cells sensitized the cells to AC and more profoundly to PAC treatment and the cells sensitivity was proportional to the expressed levels of NRP-1. Unlike NRP-1, circulating PlGF was significantly increased (<i>p</i> = 0.014) in patients with a pathological complete response (pCR). …"
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Dietary Trichosporon mycotoxinivoron modulates ochratoxin-A induced altered performance, hepatic and renal antioxidant capacity and tissue injury in broiler chickens
منشور في 2021"…Dietary OTA at all the tested levels induced the hepatic and renal tissue injury as indicated by significant decreased total antioxidant capacity in these organs along with significant decreased (p ≤ 0.05) serum concentrations of total proteins and albumin. …"
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Stress Management Using Physiological Signals and Audio Stimulation
منشور في 2021احصل على النص الكامل
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Feasibility of a group-based laughter yoga therapy on anxiety and happiness among community-dwelling older adults: A quasi-experimental study
منشور في 2024"…The Geriatric Anxiety Scale and Arabic Scale of Happiness were used to evaluate the participants' anxiety and happiness levels.</p><p><br></p><h3>Results</h3><p dir="ltr">A statistically significant decrease in anxiety level among the study group compared to the control group (Pre = 16.68 (7.35), immediate = 6.65 (2.89), post three-month = 7.68 (2.75), p=<0.001 and effect size = 0.715). …"
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The promise of tirzepatide: A narrative review of metabolic benefits
منشور في 2025"…Additionally, tirzepatide exerts a beneficial impact on lipid profile parameters, including reductions in total cholesterol, low-density lipoprotein cholesterol, and triglyceride levels, while increasing high-density lipoprotein cholesterol concentrations. …"
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Modulation of gut microbiota: The effects of a fruits and vegetables supplement
منشور في 2022"…Among the serum vitamins, the folic acid level was significantly higher (<i>p</i> = 0.001) in the FVS group than in the PLA group, whereas the vitamin B2 level was significantly higher in the PLA group than in the FVS group (<i>p</i> = 0.028). …"
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Investigating vulnerability for developing eating disorders in a multi-confessional population
منشور في 2016"…Affiliating as Christian was found to significantly decrease the vulnerability to developing an ED. …"
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A GRASP Approach for Solving Large-Scale Electric Bus Scheduling Problems
منشور في 2021"…The analysis focuses on the relation between EB ranges (battery capacity) and required charging rates (in kW) on the size of the fleet needed to cover a public transport timetable. The results of the conducted computational experiments indicate that an increase in infrastructure investment through high speed chargers can significantly decrease the size of the necessary fleets. …"
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The Impact of a Computerized Potassium Alert on Adverse Drug Events and Pharmacists' Interventions
منشور في 2010"…Methods: An alert was built into the pharmacy computer system, which warned pharmacists about a potassium level greater than 5.1 mEq/L when processing an order that could increase potassium. …"
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Investigating vulnerability for developing eating disorders in a multi-confessional lebanese sample
منشور في 2015"…Being Christian was found to significantly decrease the vulnerability to developing an ED. …"
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Conceptual Skills in Leading Change: A Competence Approach to Public Sector Leadership
منشور في 2019"…The highest level of leaders makes fewer conceptual errors, and these errors increase as the levels decrease. …"
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