A novel phosphorylated STAT3 inhibitor enhances T cell cytotoxicity against melanoma through inhibition of regulatory T cells by Abou-Ghazal, Mohamed K.

“…The activation of signal transducer and activator of transcription 3 (STAT3) has been identified as a key mediator that drives the fundamental components of melanoma malignancy, including immune suppression in melanoma patients. Increasing evidence also suggests that regulatory T cells (Tregs) are important in suppressing anti-tumor immunity and play a dominant role in negating efficacious immunotherapy approaches. …”
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Selective induction of apoptosis in T-cell acute lymphoblastic leukemia by pristimerin through dual PI3K/AKT pathway inhibition and ROS generation by Shilpa Kuttikrishnan (3520079)

“…In this study, we demonstrate that Prist effectively inhibits the proliferation of T-ALL cell lines (Jurkat and Molt 4) by inducing G0/G1 cell cycle arrest and triggering intrinsic and extrinsic caspase-dependent apoptosis. Prist significantly increases reactive oxygen species (ROS) levels and depletes glutathione (GSH), leading to mitochondrial dysfunction and cytochrome c release. …”

Mapping subnational HIV mortality in six Latin American countries with incomplete vital registration systems by Local Burden of Disease HIV Collaborators (13279180)

“…Despite decreases in national HIV mortality in all countries—apart from Ecuador—across the period of study, we found broad variation in relative changes in HIV mortality at the municipality level and increasing relative inequality over time in all countries. …”

Managing span of control efficiency and effectiveness by El-Kassar, Abdul-Nasser

“…Purpose The purpose of this paper is to address the following issues: first, the significance of the three independent variables (the chassis, trim, and assembly departments) on the three outputs (direct run loss first time capability, jobs per hour (JPH) lost, and injury rate); second, the optimal level of span of control based on the best achieved outputs; and third, whether increasing the span of control post 2009 improved manufacturing outputs in comparison with a span of control pre 2009. …”
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Does Ultrasound Really Good Enough to Evaluate the Pneumothorax in the Emergency Department by Atilla Temel (17788481)

“…Thorax ultrasonography is a useful technique with high specificity in diagnosing pneumothorax, but its sensitivity decreases significantly when the size is below 1 cm.…”

E-cigarettes in the Middle East: The known, unknown, and what needs to be known next by Mohammed, Al-Hamdani

“…The prevalence of electronic cigarettes (e-cigarettes) is increasing globally. Population-level data from several nations suggest that a higher proportion of youth and young adults are using e-cigarettes compared to the general population. …”
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Dynamics of Muslim consumers’ behavior toward Halal products by Osama Sam Al-Kwifi (18061030)

“…</p><h3>Findings</h3><p dir="ltr">Across all participants, the level of brain activation in the ventromedial prefrontal cortex increased significantly when Halal images were presented to them. …”

Deep Learning for the Accurate Prediction of Triggered Drug Delivery by Husseini, Ghaleb

“…The model accurately predicts drug release from liposomes and MOFs under various conditions, including low- and high-frequency ultrasound (extrinsic triggering), microwave exposure (extrinsic triggering), ultraviolet light exposure (extrinsic triggering), and different pH levels (intrinsic triggering). The deep learning-based predictions significantly outperform linear predictions, proving the utility of advanced computational methods in drug delivery. …”
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The impact of environment concern and attitude on green purchasing behavior by Dagher, Grace K.

“…The findings revealed that green marketers could benefit from increasing the level of environmental concern and attitude among both males and females. …”
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Profiling the autoantibody repertoire reveals autoantibodies associated with mild cognitive impairment and dementia by Hanan Ehtewish (17149825)

“…The exact mechanisms underlying the initiation and progression of the disease remain to be fully defined. There is an increasing body of evidence for the role of immune dysregulation in the pathogenesis of dementia, where blood-borne autoimmune antibodies have been studied as potential markers associated with pathological mechanisms of dementia. …”

Developing an Urban Resilience Index for Ajman City by ALSHAMSI, ALYA

“…With global urbanisation accelerating, new regulations are needed to protect urban ecosystems, species, and the services they offer, ensuring more viable, adaptable, and liveable cities. The increase in the research of sustainable development has enhanced the awareness and attention of various global sectors such as developers and policymakers regarding advanced sustainable cities, along with the associated impact of sustainability in terms of the urban transformation. …”
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Small molecule inhibition of stat3 enhances survival in mice with intracerebral melanoma by Abou-Ghazal, Mohamed

“…In addition, WP1066 decreased the level of c-Myc and survivin in melanoma cells in a dose- and time-dependent manner. …”
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An Investigation into the factors influencing Arabic speaking students’ proficiency in the Arabic language in Dubai British School by AL AHMAD, ALAAEDDIN MEHY

“…Given the high number of British as well as other non-Arabic schools in Dubai, this is a significant issue as many Arabic-speaking students are failing to achieve proficiency in their native language. …”
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Effect of national culture on the design of management control systems of multinational enterprises by Elgammal, Walid

“…Companies increasingly need to know whether management control systems or tools that are effective in one national setting will have alternate levels of effectiveness if used in a different national setting. …”
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Developing a Sustainable Procurement Action Plan for Public Sector in Ajman by Al Abdooli, Aisha Mohamed

“…Depletion of natural resources, affecting biodiversity and increasing poverty are common challenges faced by many communities all around the world. …”
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Light chain amyloidosis presenting with autoimmune hepatitis-primary sclerosing cholangitis overlap syndrome by Hammad Shabir Chaudhry (20376378)

“…Her liver enzymes (Alkaline phosphatase, Alanine aminotransferase, Aspartate aminotransferase had decreased significantly.</p><h3>Conclusions</h3><p dir="ltr">AL amyloidosis can very rarely present as AIH-PSC overlap syndrome, manifesting with raised liver enzymes, biliary strictures, pruritis and positive liver antibodies. …”

Engagement of family members, corporate governance and social responsibility in family-owned enterprises by El-Kassar, Abdul-Nasser

“…Purpose With the increasing awareness and recognition of the importance of corporate governance (CG), its practices and mechanisms along with their effect on performance and general organization’s behavior have become of interest for many scholars. …”
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Therapeutic challenges in the management of osmotic demyelination syndrome by Mohamed Elshafei (9376832)

“…</p><h3>Outcomes</h3><p dir="ltr">Significant improvement in patients’ conscious level and motor function with the commencement of sodium relowering therapy. …”

Theoretical insight into effect of cation–anion pairs on CO₂ reduction on bismuth electrocatalysts by Sun Hee Yoon (7179263)

“…In the presence of the cation–anion pairs (M⁺/X⁻), Eads of the pairs on hydrated Bi (Bi-2H) becomes more negative than that in the cases of anions or cations alone, particularly when the ionic radius of the paired cation and anion do not differ significantly. Such a synergistic effect of the mixed ions is also observed for the work function values. …”

Using XAI Techniques to Detect Targeted Data Poisoning Attacks on Healthcare Applications of Machine Learning Systems by Eyad Dhaher Megdadi

“…As machine learning becomes increasingly integrated into critical fields like healthcare, the integrity and security of training data have become paramount concerns. …”
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