Image 1_Huoxiang Zhengqi dropping pills alleviate exertional heat stroke–induced multiple organ injury through sustaining intestinal homeostasis via regulating MAPK/NF-κB pathway a... حسب Lei Li (29537)

"…Additionally, HXZQD positively regulated gut microbiota, increasing the proportion of beneficial Lactococcus and decreasing harmful Streptococcus. These findings suggest that HXZQD maintains intestinal homeostasis during EHS by preserving barrier function and modulating gut microbiota, offering a promising preventive approach for EHS management.…"

Supplementary file 1_Mechanistic insights into the PAI-1 inhibitor PAItrap3: enhancing lipid metabolism in adipose tissue of diabetic db/db mice.xlsx حسب Linxi Wang (3068649)

"…Objective<p>This study aimed to investigate the effects of PAItrap3, a novel PAI-1 inhibitor, on lipid metabolism, and autophagy pathways in diabetic mice.…"

Data Sheet 1_Huoxiang Zhengqi dropping pills alleviate exertional heat stroke–induced multiple organ injury through sustaining intestinal homeostasis via regulating MAPK/NF-κB path... حسب Lei Li (29537)

"…Additionally, HXZQD positively regulated gut microbiota, increasing the proportion of beneficial Lactococcus and decreasing harmful Streptococcus. These findings suggest that HXZQD maintains intestinal homeostasis during EHS by preserving barrier function and modulating gut microbiota, offering a promising preventive approach for EHS management.…"

Table 1_Global, regional, and national burden of liver cancer in adolescents and young adults from 1990 to 2021: an analysis of the global burden of disease study 2021 and forecast... حسب Jingyu Wen (13913130)

"…</p>Interpretation<p>Despite a gradual decline in liver cancer burden among AYAs, NASH is emerging as a significant and rising cause of incidence and mortality. …"

Table 1_Weight loss increases circadian gene expression and emotional well-being in individuals with obesity.docx حسب Carmen Grau-del Valle (22686341)

"…This study aimed to investigate the effects of weight loss by a dietary intervention on circadian gene expression and emotional state in individuals with obesity.…"

Table1_Metabolomic disorders caused by an imbalance in the gut microbiota are associated with central precocious puberty.docx حسب Chunjie Liu (3437477)

"…</p>Results<p>The gut microbiota composition in CPP patients was significantly different from that in healthy controls, characterized by an increased abundance of Faecalibacterium and a decreased abundance of Anaerotruncus. …"

Table 1_Network pharmacology and experimental validation to elucidate the pharmacological mechanisms of OATF against kidney stones.xlsx حسب Sisi Dai (7837886)

"…In vivo, OATF significantly decreased serum creatinine (SCR), serum calcium (Ca), serum phosphorus (P), and blood urea nitrogen (BUN) levels in CaOx-induced Sprague-Dawley (SD) rats, indicating its protective effects against KS.…"

Image 4_Inhibition SIRT1 to regulate FOXP3 or RORγt can restore the balance of Treg/Th17 axis in ulcerative colitis and enhance the anti-inflammatory effect of moxibustion.tif حسب Yuanbing Zhu (20538638)

"…Finally, in vivo studies, the results have shown that administering EX-527 to inhibit SIRT1 leads to an increasing in FOXP3 expression and a decreasing in RORγt expression in UC colon tissue. …"

Data Sheet 2_Early boosting of p38 MAPK signaling pathway by lycorine hydrochloride potently inhibits PRRSV proliferation in primary and established cells.pdf حسب Lizhan Su (19936980)

"…In summary, this study reveals that early boosting of p38 MAPK signaling pathway induced by LH treatment significantly suppresses PRRSV propagation, and LH has the potential to be used as a novel antiviral agent against PRRSV infections.…"

Raw data of this work. حسب Ming Liu (105953)

"…The rate of persistent non-depression is approximately 30% higher than that of persistent depression, and both have a downward trend over years. Positive youth development and healthy family function are protective factors of depression, while school maladjustment decreases persistent non-depression. …"

Image 2_Inhibition SIRT1 to regulate FOXP3 or RORγt can restore the balance of Treg/Th17 axis in ulcerative colitis and enhance the anti-inflammatory effect of moxibustion.tif حسب Yuanbing Zhu (20538638)

"…Finally, in vivo studies, the results have shown that administering EX-527 to inhibit SIRT1 leads to an increasing in FOXP3 expression and a decreasing in RORγt expression in UC colon tissue. …"

Supplementary file 1_Model-based multi-year P flow analyses and strategies for sustainable food chain management in Changzhou city at China's Taihu Basin.docx حسب Zheng Guo (14989)

"…Besides, urine diversion and waste incineration scenarios significantly decreased P accumulation in the food chain. …"

Data Sheet 4_The power of GM-CSF: immune regulation in the defense against Phialophora verrucosa infection.pdf حسب Qi Dong (119569)

"…</p>Results<p>Compared to WT mice, GM-CSF deficiency significantly delayed fungal clearance and prolonged disease progression, accompanied by reduced inflammatory responses and decreased neutrophil infiltration. …"

Data Sheet 1_Early boosting of p38 MAPK signaling pathway by lycorine hydrochloride potently inhibits PRRSV proliferation in primary and established cells.pdf حسب Lizhan Su (19936980)

"…In summary, this study reveals that early boosting of p38 MAPK signaling pathway induced by LH treatment significantly suppresses PRRSV propagation, and LH has the potential to be used as a novel antiviral agent against PRRSV infections.…"

Data Sheet 1_Effects of pathogen infection and Rhizobium inoculation on instantaneous and long-term water use efficiency of peanut with and without drought.docx حسب Girmaye Benti Regassa (21592523)

"…Inoculation Fusarium sp. and co-inoculation Rhizobium and Fusarium sp. reduced WUE_i by decreasing plant height with drought. Inoculation Rhizobium and Fusarium sp. significantly reduced WUE_L by lowering intercellular CO₂ concentration without drought. …"

Data Sheet 1_Inhibition SIRT1 to regulate FOXP3 or RORγt can restore the balance of Treg/Th17 axis in ulcerative colitis and enhance the anti-inflammatory effect of moxibustion.pdf... حسب Yuanbing Zhu (20538638)

"…Finally, in vivo studies, the results have shown that administering EX-527 to inhibit SIRT1 leads to an increasing in FOXP3 expression and a decreasing in RORγt expression in UC colon tissue. …"

Supplementary file 2_Scorpion-Centipede extracts mitigate ovariectomy-induced osteoporosis in mice through facilitating Cx3cr1 expression.docx حسب Jinghuai Ni (21023477)

"…Objectives<p>Scorpion and Centipede (SC) is an ancient formula of traditional Chinese medicine that is commonly utilized in a range of disorders, and it has been shown to have pharmacological effects on postmenopausal osteoporosis (PMOP). …"

Table 1_Effects of salinity stress on morphological structure, physiology, and mRNA expression in different wheat (Triticum aestivum L.) cultivars.doc حسب Xiaohui Sun (520181)

"…<p>Salinity is a major abiotic stress that threatens crop yield and food supply in saline soil areas. …"

Table2_Metabolomic disorders caused by an imbalance in the gut microbiota are associated with central precocious puberty.docx حسب Chunjie Liu (3437477)

"…</p>Results<p>The gut microbiota composition in CPP patients was significantly different from that in healthy controls, characterized by an increased abundance of Faecalibacterium and a decreased abundance of Anaerotruncus. …"

Supplementary file 1_Scorpion-Centipede extracts mitigate ovariectomy-induced osteoporosis in mice through facilitating Cx3cr1 expression.docx حسب Jinghuai Ni (21023477)

"…Objectives<p>Scorpion and Centipede (SC) is an ancient formula of traditional Chinese medicine that is commonly utilized in a range of disorders, and it has been shown to have pharmacological effects on postmenopausal osteoporosis (PMOP). …"