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significantly affect » significantly affected (Expand Search), significant effect (Expand Search), significant effects (Expand Search)
increase release » increased release (Expand Search), increased reliance (Expand Search), increase cellarea (Expand Search)
affect decrease » effects decreased (Expand Search), largest decrease (Expand Search)
significantly affect » significantly affected (Expand Search), significant effect (Expand Search), significant effects (Expand Search)
increase release » increased release (Expand Search), increased reliance (Expand Search), increase cellarea (Expand Search)
affect decrease » effects decreased (Expand Search), largest decrease (Expand Search)
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In microglia, C1 reduced NO release triggered by IFNγ and PolyIC, and did not affect LPS induced cytokine release.
Published 2023“…Treatment with C1 (in blue) did not have a significant effect for the LPS-induced IL6 and TNFα release, but increased the release of IL1β at all tested concentrations (0.025 μM: p = 0.0037, 0.25 μM: p < 0.0001, 2.5 μM: p < 0.0001). …”
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C1 alone does not evoke NO release, an increase in cell activity or release of pro-inflammatory cytokines.
Published 2023“…As shown in <b><a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0278325#pone.0278325.g001" target="_blank">Fig 1</a></b>, LPS stimulation induced a significant increase in NO release (p<0.0001). Treatment with C1 or DMSO did not show any significant difference compared to untreated microglia (in white). …”
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AZ10606120 treatment does not significantly increase apoptosis mediated cell death.
Published 2025Subjects: