Circulating Endothelial Microparticles Reduce in Concentration Following an Exercise Programme in Women With Polycystic Ovary Syndrome by Richard J. Kirk (18174919)

“…</p><h3>Results</h3><p dir="ltr">CD105+MP significantly reduced in women with PCOS from pre to post-exercise programme, with CD105+ MP reducing from 2114 CD105+ MP per μl platelet free plasma (PFP) to 424 CD105+ MP per μl PFP (<i>p</i> = 0.025). …”

Two-surgeon technique of parenchymal transection contributes to reduced transfusion rate in patients undergoing major hepatectomy by Palavecino, Martin

“…Although transfusion rates can be reduced to almost 0 in uncomplicated hepatectomies, the blood transfusion rates associated with liver resection remain significant at tertiary referral centers, such as ours. …”
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An imageable retinoid acid derivative to detect human cancer xenografts and study therapeutic dosing to reduce its toxicity by Wang, Wei

“…Those agents will specifically target the disease markers for diagnosis and apply the biologically effective dose for treatment. …”
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Does colchicine reduce mortality in patients with COVID-19 clinical syndrome? An umbrella review of published meta-analyses by Mohammed I., Danjuma

“…BackgroundDespite significant improvements in both treatment and prevention strategies, as well as multiple commissioned reviews, there remains uncertainty regarding the survival benefit of repurposed drugs such as colchicine in patients with Coronavirus Disease 2019 (COVID-19) clinical syndrome. …”
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Does colchicine reduce mortality in patients with COVID-19 clinical syndrome? An umbrella review of published meta-analyses by Mohammed I. Danjuma (13569767)

“…<h3>Background</h3><p dir="ltr">Despite significant improvements in both treatment and prevention strategies, as well as multiple commissioned reviews, there remains uncertainty regarding the survival benefit of repurposed drugs such as colchicine in patients with Coronavirus Disease 2019 (COVID-19) clinical syndrome.…”

Design and Evaluation of a Just-in-Time Adaptive Intervention (JITAI) to Reduce Sedentary Behavior at Work: Experimental Study by Tasnim Ismail (18418554)

Burden and disease pathogenesis of influenza and other respiratory viruses in diabetic patients by Swapna Thomas (17337925)

“…Vaccinating diabetic patients against influenza would significantly reduce hospitalization due to disease severity. …”

Sestrin2 as a Novel Biomarker and Therapeutic Target for Various Diseases by Mazhar Pasha (11197767)

“…Thus, the aim of this review is to discuss the upstream regulators and the downstream effectors of Sestrins and to highlight the significance of Sestrin2 as a biomarker and a therapeutic target in diseases such as metabolic disorders, cardiovascular and neurodegenerative diseases, and cancer.…”

Being female with vitiligo disease in traditional societies within North Africa by Mohamed Faraj Saleh Raheel (21633068)

“…However, the illness profoundly impacted patients’ lives emotionally, with clear consequences, including diminished emotional satisfaction and reduced social participation. The results of this study highlight the negative effects that vitiligo disease can have on women’s quality of life within traditional Libyan society. …”

Systematic analysis of healthcare big data analytics for efficient care and disease diagnosing by Sulaiman Khan (12585349)

“…It contains a gigantic amount of data, especially a plethora of data types that has been significantly useful in diverse research domains. In healthcare domain, the researchers use computational devices to extract enriched relevant information from this data and develop smart applications to solve real-life problems in a timely fashion. …”

Air pollution burden of disease over highly populated states in the Middle East by Rima J. Isaifan (8350056)

“…</p><h3>Conclusions </h3><p dir="ltr">The results indicate a significant impact of air pollution due to long-term exposure to fine particles resulting in early mortality. …”

Altered regulation of cell migration in IRF6-mutated orofacial cleft patients-derived primary cells reveals a novel role of RhoGTPases in cleft/lip palate development by Al Saneh, Mounir

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Combined bronchodilators (tiotropium plus olodaterol) for patients with chronic obstructive pulmonary disease by Ramadan, Wijdan H.

“…For patients not sufficiently controlled on a single long-acting bronchodilator, a combination of different bronchodilators has shown a significant increase in lung function. Tiotropium, a once-daily dosing LAMA, demonstrated sustained improvements in lung function as well as improved health-related quality of life, reduced exacerbations, and increased survival without altering the rate of decline in the mean forced expiratory volume in 1 second (FEV1) with fairly tolerable side effects. …”
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Gut Microbiota in Familial Mediterranean Fever: Insights into Microbial Patterns and Disease Severity by Rukaya Basala

“…Our findings revealed no significant differences in gut microbiota composition or diversity between FMF patients and healthy controls, nor among FMF subgroups stratified by disease severity. …”
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Exome sequence analysis of rare frequency variants in Late-Onset Alzheimer Disease by Sudharsana Sundarrajan (3181371)

“…<p dir="ltr">Alzheimer disease (AD) is a leading cause of dementia in elderly patients who continue to live between 3 and 11 years of diagnosis. …”

Exendin-4 alleviates steatosis in an in vitro cell model by lowering FABP1 and FOXA1 expression via the Wnt/-catenin signaling pathway by Olfa Khalifa (10914452)

“…Further treatment with 200 nM Ex-4 for 3 h significantly reduced the OA-induced lipid accumulation (p < 0.05). …”

Whole blood DNA aberrant methylation in pancreatic adenocarcinoma shows association with the course of the disease by El Maarri, Osman

“…Pancreatic tumors are usually diagnosed at an advanced stage in the progression of the disease, thus reducing the survival chances of the patients. …”
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Spatial, temporal, and demographic patterns in prevalence of smoking tobacco use and attributable disease burden in 204 countries and territories, 1990–2019: a systematic analysis... by Marissa B Reitsma (8674341)

“…</p><p><br></p><h3>Methods</h3><p dir="ltr">We estimated the prevalence of smoking tobacco use and attributable disease burden for 204 countries and territories, by age and sex, from 1990 to 2019 as part of the Global Burden of Diseases, Injuries, and Risk Factors Study. …”

The role of preoperative transfusion in sickle cell disease, a systematic review and meta-analysis by Yasamin Abdu (15899155)

“…Notably, the increased bleeding risk observed seldom had clinical significance. We recommend individualizing management strategies, considering the overall positive impact of transfusions in reducing complications. …”

Trends of the Dementia Burden in South Asia: An Analysis of 2021 Global Burden of Disease Study by Shubham Chauhan (21334742)

“…While prevalence rates experienced a minor decline, Disability‐Adjusted Life Years (DALYs) rose from 272.02 to 308.27 per 100,000, reflecting an increasing burden of the disease. Notably, Nepal significantly reduced its incidence rates, while Pakistan saw an increase in mortality rates. …”