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Identification of Genes Associated with Familial Focal Segmental Glomerulosclerosis Through Transcriptomics and In Silico Analysis, Including RPL27, TUBB6, and PFDN5
Published 2024“…The study focuses on the use of bioinformatic analysis of gene expression data to identify genes associated with familial FSGS. A comprehensive in silico analysis was performed using the GSE99340 data set from Gene Expression Omnibus (GEO) comparing gene expression in glomerular and tubulointerstitial tissues from FSGS patients (n = 10) and Minimal Change Disease (MCD) patients (n = 8). …”
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Patients with early onset of type 1 diabetes have significantly higher GG genotype at position 49 of the CTLA4 gene
Published 2004“…The GG genotype was also significantly higher among patients (12.6%) than in controls (4.2%). χ2 analysis and family-based association studies were performed and suggested the association of CTLA4 exon 1 G polymorphism with T1D (p = 0.0229). …”
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Dietary patterns in cardiovascular diseases prevention and management
Published 2014“…Using data from the national Nutrition and Non-Communicable Disease Risk Factor Survey, we appraised the association of dietary patterns with CVD risk factors among Lebanese adults. …”
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Prevalence, Associated Risk Factors, and Adverse Cardiovascular Outcomes of Statins Discontinuation: A Systematic Review
Published 2024“…<h3>Purpose</h3><p dir="ltr">Statins are widely prescribed for cardiovascular diseases (CVD) prevention; however, a significant proportion of users discontinue the medication for various reasons. …”
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Salivary α-amylase activity is associated with cardiometabolic and inflammatory biomarkers in overweight/obese, non-diabetic Qatari women
Published 2024“…</p><h3>Conclusion</h3><p dir="ltr">Our findings delineate significant associations between sAAa and markers indicative of cardiovascular disease risk and inflammation among overweight/obese adult Qatari females. …”
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Small molecule inhibition of stat3 enhances survival in mice with intracerebral melanoma
Published 2008“…Development of new, effective therapies for metastatic melanoma that target novel pathways associated with the genesis of metastatic disease is a major unmet clinical need. …”
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Genetic Basis and Prognostic Value of Exercise QT Dynamics
Published 2020“…Increased QT dynamics during recovery was significantly associated with all-cause mortality in the univariate Cox regression analysis (hazard ratio, 1.09 [95% CI, 1.05–1.13], P =2.28×10 -5 ), but the association was not significant after adjusting for clinical risk factors.…”
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Epigenetic analysis of Paget’s disease of bone identifies differentially methylated loci that predict disease status
Published 2021“…<p dir="ltr">Paget’s disease of bone (PDB) is characterized by focal increases in disorganized bone remodeling. …”
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Aorta deformation linked to heart disease
Published 2015“…<p>A cardiovascular condition called hypertrophic cardiomyopathy is associated with abnormal mechanical properties of the aorta, which could be used in the clinic to assess risk for the disease, according to new research published in the journal Global Cardiology and Practice . …”
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Sestrin2 as a Novel Biomarker and Therapeutic Target for Various Diseases
Published 2017“…Thus, the aim of this review is to discuss the upstream regulators and the downstream effectors of Sestrins and to highlight the significance of Sestrin2 as a biomarker and a therapeutic target in diseases such as metabolic disorders, cardiovascular and neurodegenerative diseases, and cancer.…”
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Parkinson’s disease and schizophrenia interactomes contain temporally distinct gene clusters underlying comorbid mechanisms and unique disease processes
Published 2024“…<p dir="ltr">Genome-wide association studies suggest significant overlaps in Parkinson’s disease (PD) and schizophrenia (SZ) risks, but the underlying mechanisms remain elusive. …”
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Olodaterol for the treatment of chronic obstructive pulmonary disease
Published 2016“…In 48- and 6-week Phase III clinical trials of olodaterol evaluating various lung function and symptomatic outcomes in patients with moderate to very severe COPD, olodaterol use was associated with significant improvements in spirometry outcomes, such as postbronchodilator forced expiratory volume in one second (FEV1), as well as dyspnea severity and quality-of-life measures. …”
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Suppression of Unstable Flow by Using Rough Surfaces at Small Mass Flow Rates in a Radial Diffuser
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Inflammatory Markers and COVID-19 Disease Progression
Published 2023“…</p> <h3>Conclusions</h3> <p>The data suggest a significant association between levels of inflammatory markers and COVID-19 severity. …”