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Novel thiazolones for the simultaneous modulation of PPARγ, COX-2 and 15-LOX to address metabolic disease-associated portal inflammation
منشور في 2025"…A hybrid pharmacophore model, based on structural motifs previously identified by our team, was employed to generate ligands that simultaneously target COX-2, 15-LOX, and PPARγ in the context of metabolic dysfunction-associated fatty liver disease (MAFLD). Notable COX-2 inhibitory activities (IC50 = 0.065–0.24 μM) were observed relative to celecoxib (IC50 = 0.049 μM). …"
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Correction: Prevalence of polypharmacy and the association with non-communicable diseases in Qatari elderly patients attending primary healthcare centers: A cross-sectional study
منشور في 2020"…<p dir="ltr">Correction to: Prevalence of polypharmacy and the association with non-communicable diseases in Qatari elderly patients attending primary healthcare centers: A cross-sectional study. …"
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“Inflammatory potential of the diet and its association with physical, mental, and gut health among Lebanese adults
منشور في 2022"…From there findings demonstrated through its inflammatory potential diet is associated to several aspects of health, like chronic diseases, gut health and mental health. …"
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masterThesis -
25
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Evaluation of Health Literacy Levels and Associated Factors Among Patients with Acute Coronary Syndrome and Heart Failure in Qatar
منشور في 2023"…<h3>Purpose </h3><p dir="ltr">To determine the prevalence of inadequate health literacy and its associated risk factors among patients with acute coronary syndrome (ACS) and/or heart failure (HF) in Qatar.…"
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Novel thiazolones for the simultaneous modulation of PPARγ, COX-2 and 15-LOX to address metabolic disease-associated portal inflammation
منشور في 2025"…<p dir="ltr">A hybrid pharmacophore model, based on structural motifs previously identified by our team, was employed to generate ligands that simultaneously target COX-2, 15-LOX, and PPARγ in the context of metabolic dysfunction-associated fatty liver disease (MAFLD). Notable COX-2 inhibitory activities (IC<sub>50</sub> = 0.065–0.24 μM) were observed relative to celecoxib (IC<sub>50</sub> = 0.049 μM). …"
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Parallel multi-voltage power minimization in VLSI circuits. (c2013)
منشور في 2013احصل على النص الكامل
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masterThesis -
30
Spectrum of genetic variants associated with maple syrup urine disease in the Middle East, North Africa, and Türkiye (MENAT): a systematic review
منشور في 2025"…</p><h3>Aim</h3><p dir="ltr">This study aimed to systematically review the variants significantly associated with MSUD in the MENAT region.…"
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Restless legs syndrome in multiple sclerosis patients: Prevalence, impact, and association with disease-modifying therapies in a Saudi Arabian pilot study
منشور في 2023"…Notably, a statistically significant variance in IRLSSG scores was observed when contrasting Fingolimod and Aubagio treatments (<i>P</i> < 0.001).…"
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Stemming cardiovascular diseases in Qatar
منشور في 2015"…</p><p>All of these factors are associated with reduced physical activity and increased consumption of high-fat foods. …"
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Association of single nucleotide polymorphisms with dyslipidemia and risk of metabolic disorders in the State of Qatar
منشور في 2023"…</p><h3>Conclusion</h3><p dir="ltr">The current investigation provides evidence of association for a common SNP to coronary heart disease and suggests a sex-dependent effect and encourage potential therapeutic applications.…"
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Circulating and Tumor-Infiltrating Immune Checkpoint-Expressing CD8+ Treg/T Cell Subsets and Their Associations with Disease-Free Survival in Colorectal Cancer Patients
منشور في 2022"…Importantly, we investigated associations between different tumor-infiltrating CD8+ T cell subpopulations and disease-free survival (DFS) in CRC patients. …"
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The clinical characteristics and outcomes of patients with pulmonary hypertension in association with hyperthyroid state: A systematic review
منشور في 2022"…Various etiologies and treatments did not have any significant differences in the outcome of PHTN.</p><h3>Conclusions</h3><p dir="ltr">PHTN can be present at the initial diagnosis of HTH, which is associated with better outcomes of PHTN. …"
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Sugar-Sweetened Beverages Contribute Significantly to College Students’ Daily Caloric Intake in Jordan: Soft Drinks Are Not the Major Contributor
منشور في 2019"…<div><p>Sugar sweetened beverages (SSBs) are caloric-dense and associated with poor diet quality which may result in weight gain and obesity. …"
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Transcriptome of Tumor-Infiltrating T Cells in Colorectal Cancer Patients Uncovered a Unique Gene Signature in CD4+ T Cells Associated with Poor Disease-Specific Survival
منشور في 2021"…The top 200 deregulated genes in CD4<sup>+</sup> TILs were aligned with the cancer genome atlas (TCGA) CRC dataset to identify a unique gene signature associated with poor prognosis. Moreover, 69 upregulated and 20 downregulated genes showed similar trends of up/downregulation in the TCGA dataset and were used to calculate “poor prognosis score” (ppScore), which was significantly associated with disease-specific survival. …"
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Identification of Genes Associated with Familial Focal Segmental Glomerulosclerosis Through Transcriptomics and In Silico Analysis, Including RPL27, TUBB6, and PFDN5
منشور في 2024"…The study focuses on the use of bioinformatic analysis of gene expression data to identify genes associated with familial FSGS. A comprehensive in silico analysis was performed using the GSE99340 data set from Gene Expression Omnibus (GEO) comparing gene expression in glomerular and tubulointerstitial tissues from FSGS patients (n = 10) and Minimal Change Disease (MCD) patients (n = 8). …"
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article