Selective induction of apoptosis in T-cell acute lymphoblastic leukemia by pristimerin through dual PI3K/AKT pathway inhibition and ROS generation by Shilpa Kuttikrishnan (3520079)

“…In this study, we demonstrate that Prist effectively inhibits the proliferation of T-ALL cell lines (Jurkat and Molt 4) by inducing G0/G1 cell cycle arrest and triggering intrinsic and extrinsic caspase-dependent apoptosis. Prist significantly increases reactive oxygen species (ROS) levels and depletes glutathione (GSH), leading to mitochondrial dysfunction and cytochrome c release. …”

Long-Chain Acyl-CoA Synthetase 1 Role in Sepsis and Immunity: Perspectives From a Parallel Review of Public Transcriptome Datasets and of the Literature by Jessica Roelands (7516439)

“…Furthermore, available clinical data indicate that levels of ACSL1 and ACSL4 induction was significantly higher in fatal cases of sepsis. …”

Children diabetes prevention camps by Nature Research (16552612)

“…These percentages are significantly higher than the region’s average (13% and 24.5%, respectively). …”

Perceptions and Practices Related to Twice-Exceptional Learners in K-12 American Private Schools in Dubai by FAKIH, MIRNA KHALIL

“…Results of the study have revealed that stakeholders and K–12 teachers have shown different perceptions, experiences, and low levels of awareness towards the education of twice-exceptional learners due to many factors and challenges. …”
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Risk Factors for Post-Cesarean, Surgical Site Infections in a Multi-Ethnic Population of Qatar by Sufia Athar (14777830)

“…</p><h3>Conclusion</h3><p dir="ltr">This study provides baseline levels for SSI after CD across several different patient subgroups. …”

Environmental movement in Lebanon by Djoundourian, Salpie

“…Using the total number of established environmental organizations and the level of reported activities aimed at spreading environmental awareness and educating people as indicators of private sector involvement in the environmental movement, the paper concludes that the post war era is characterized by a significant increase in the number of established organizations. …”
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Profiling the autoantibody repertoire reveals autoantibodies associated with mild cognitive impairment and dementia by Hanan Ehtewish (17149825)

“…And 20 proteins had significantly altered autoantibody responses in MCI compared to cognitively normal individuals. …”

Deep Learning for the Accurate Prediction of Triggered Drug Delivery by Husseini, Ghaleb

“…The model accurately predicts drug release from liposomes and MOFs under various conditions, including low- and high-frequency ultrasound (extrinsic triggering), microwave exposure (extrinsic triggering), ultraviolet light exposure (extrinsic triggering), and different pH levels (intrinsic triggering). The deep learning-based predictions significantly outperform linear predictions, proving the utility of advanced computational methods in drug delivery. …”
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Willingness to Pay for Clean Air: Evidence from the UK by Maarraoui, Giorgio

“…The willingness to pay for clean air is also significant and increases with level of education. These measurements derived can be used as benchmarks for pollution abatement subsidies or pollution taxes and can help in projecting a more comprehensive assessment of costs and benefits.…”
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Construction workforce management strategies to reduce absenteeism by Lattouf, M. Ghayth

“…Despite the international location of the survey, the results indicate a worker demographic similar to that found in the southwestern United States and other areas with significant residential construction. The results also serve to highlight the significance of basic management techniques in reducing absenteeism: adopting training programs to increase the skill level of workers, providing incentives to increase the tenure of workers onsite, and arranging the working schedule to favor less overtime.…”
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Synthesis and analysis of silver–copper alloy nanoparticles of different ratios manifest anticancer activity in breast cancer cells by Sara Al Tamimi (9692615)

“…Furthermore, we observed the cell death pathway by the apoptosis marker Annexin-V which showed non-significant results, while the exposure of AgCu-NP in MCF-7 cells leads to toxicity and also caused significant increase in MMP-9 level, which suggests the cell death may be associated with other pathways such as autophagy and oxidative stress related.…”

How FIFA World Cup 2022™ can meet the carbon neutral commitments and the United Nations 2030 Agenda for Sustainable Development?: Reflections from the tree nursery project in Qatar... by Ioannis Spanos (2086933)

“…Tree nurseries with stress-tolerant variants play a significant role in cutting the excess emissions from Qatar 2022, thereby supporting long-term sustainable development. …”

Unsustainability in emergent systems by Haddad, Marc

“…These challenges are already significant enough to seriously hamper the network's ability to deliver an acceptable level of service within reasonable norms for environmental, health and safety impacts, especially in and around the country's major urban centers. …”
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The impact of environment concern and attitude on green purchasing behavior by Dagher, Grace K.

“…The findings revealed that green marketers could benefit from increasing the level of environmental concern and attitude among both males and females. …”
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Cardiorespiratory Fitness and Performance Adaptations to High-Intensity Interval Training: Are There Differences Between Men and Women? A Systematic Review with Meta-Analyses by Merilyn Lock (9440240)

“…Data were sub-grouped for men and women, baseline training level, mean age, intervention type, and intervention length. …”

Frugal innovation for sustainable rural development by Mokter, Hossain

“…However, certain SDGs have limited potential for frugal or other types of innovation to make significant contributions, as these goals are mainly intended to be assessed at the national level. …”
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One-year experience of hybrid closed-loop system in children and adolescents with type 1 diabetes previously treated with multiple daily injections: drivers to successful outcomes by Goran Petrovski (129836)

“…</p> <h2>Conclusion</h2> <p>HCL system (MiniMed 670G) in children and adolescents previously treated with MDI significantly improves glycemic outcomes (HbA1c and Time in Ranges) immediately during the first month. …”

Economic policy uncertainty: Global energy security with diversification by Dagar, Vishal

“…To obtain a sustainable level of ED, policymakers should increase investment in gross capital formation because economic growth and openness via pro-global policies have less impact on ED. …”
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The molecular mechanisms of apoptosis accompanied with the epigenetic regulation of the NY-ESO-1 antigen in non-small lung cancer cells treated with decitabine (5-aza-CdR) by Varghese P. Inchakalody (14557382)

“…Bisulfite-sequencing demonstrated 45.6% demethylation efficiency at the NY-ESO-1 gene promoter region and RT-qPCR analysis confirmed the significant induction of NY-ESO-1 at mRNA level (128-fold increase, *p < 0.050). …”

G9a-mediated repression of CDH10 in hypoxia enhances breast tumour cell motility and associates with poor survival outcome by Francesco Casciello (18557613)

“…CDH10 overexpression significantly reduces cellular movements in breast cancer cell lines and prevents the hypoxia-mediated increase in cell motility. …”