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    LSPC treatment decreases neuropathology in prion-infected mice. by Heather Bender (363996)

    Published 2019
    “…<p>Immunohistochemistry (IHC) of brain sections through the (A) cerebellum and (B) hippocampus in infected and uninfected mice reveal that (A) while we observed no difference in cerebellar PrP<sup>Res</sup> accumulation among infected untreated, non-responder or responder mice, both GFAP stain intensity, a measure of astrogliosis, and vacuolation, a hallmark of prion-mediated neurodegeneration, were significantly decreased in LSPC responder mice. (B) In the hippocampus, we observed decreased PrP<sup>Res</sup>, GFAP and vacuolation in responder and non-responder mice compared to infected untreated mice. …”
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