Identifying cyst initiation candidate genes through mRNA sequencing <i>Pkd2</i> mouse kidneys at pre-cystic and early cystic time points. by Abigail O. Smith (11883787)

“…Colored dots indicate FDR <0.05, red indicates increased and blue decreased in Experimental vs Control. Plot was cropped for better visualization. (*) Data point moved for better visualization: Pkd2 [Log2(FC) = -1.13, -Log10(FDR) = 93.97], Cdkl1 [Log2(FC) = 0.42, -Log10(FDR) = 26.30]. …”

Data Sheet 1_Immunogenic cell death-related biomarkers in heart failure probed by transcriptome and single-cell sequencing.zip by Haoyue Wang (13138179)

“…In addition, the expression levels of CD163 and VSIG4 increased in subpopulations of monocytes and macrophages, whereas FPR1 showed a decreasing trend. RT-qPCR results confirmed significant down-regulation of CD163, FPR1, and VSIG4 in patients with HF and animal models.…”

Data_Sheet_1_Analysis of the global burden of cardiovascular diseases linked to exposure to ambient particulate matter pollution from 1990 to 2019.docx by Binbin Zou (11358315)

“…The ASDR and DALYs increased in low-Socio-demographic Index (SDI), low–middle-SDI, and middle-SDI countries, while they decreased in high-SDI countries. The highest burden was observed in Central Asia, North Africa, the Middle East, East Asia, and South Asia. …”

Discovery of MKP10241, a Novel Small Molecule Targeting the GPR119/Incretin Axis to Treat Metabolic Disorders by Santosh Kumar Rai (22382996)

“…Chronic treatment of MKP10241 in DIO-mice exhibited marked reduction in body weight and feed intake at tested doses, which was associated with decreased blood glucose level, lipid parameters, and body fats. …”

Data from: The impact and production of the Old World climbing fern (Lygodium microphyllum) biological control agent Lygomusotima stria, is affected by the level of host plant fert... by GREGORY WHEELER (18437559)

“…Further, two generations of feeding by larvae decreased stem weights at the lowest fertilizer level and new shoot numbers. …”

The T-type voltage-gated Ca²⁺ channel Ca_V3.1 involves in the disruption of respiratory epithelial barrier induced by <i>Pasteurella multocida</i> toxin by Haixin Bi (6867632)

“…This was evidenced by a decreased expression of tight junctions (ZO-1, occludin) and adherens junctions (β-catenin, E-cadherin), as well as enhanced cytoskeletal rearrangement. …”

Figure 4 from Impact of Glucocorticoids on Immune Checkpoint Inhibitor Efficacy and Circulating Biomarkers in Non–Small Cell Lung Cancer Patients by Lauren Polyakov (21672045)

“…<p>Continued use of corticosteroids during anti–PD-L1 therapy correlates with decreased survival in a preclinical model. <b>A,</b> Experimental set-up. …”

Table 7_The impact of Helicobacter pylori infection and eradication therapies on gut microbiota: a systematic review of microbial dysbiosis and its implications in gastric carcinog... by Alia Albush (21669206)

“…In gastric cancer patients, microbial diversity was reduced, with decreased levels of Bifidobacterium and Actinobacteria, and increased levels of Prevotella and Dialister, both associated with pro-inflammatory environments. …”

Table 1_The impact of Helicobacter pylori infection and eradication therapies on gut microbiota: a systematic review of microbial dysbiosis and its implications in gastric carcinog... by Alia Albush (21669206)

“…In gastric cancer patients, microbial diversity was reduced, with decreased levels of Bifidobacterium and Actinobacteria, and increased levels of Prevotella and Dialister, both associated with pro-inflammatory environments. …”

Data Sheet 1_ROS-mediated membrane damage and antioxidant imbalance drive apple flesh browning during cold storage.csv by Jihan Wang (577833)

“…Total antioxidant capacity decreased by ~25% in FB, accompanied by significant reductions in AsA and GSH and lower CAT/APX activities. …”

Data Sheet 2_Complement activation drives the phagocytosis of necrotic cell debris and resolution of liver injury.pdf by Sofie Vandendriessche (638514)

“…Importantly, C3 deficiency led to a significant accumulation of necrotic debris and impairment of liver recovery in mice, which was attributed to decreased phagocytosis of debris by recruited neutrophils in vivo. …”

Image 2_Bmi1 deficiency exacerbates hyperoxia-induced acute lung injury in mice.tif by Helena Hernández-Cuervo (9956465)

“…</p>Results<p>Mice lacking Bmi1 versus WT exposed to hyperoxia exhibited hallmarks of human acute lung injury (ALI) such as increased lung permeability, alveolar edema, hemorrhage, interstitial thickening, and infiltration of immune cells; and alterations in lung mechanics, including increased elastance and decreased lung compliance.</p>Discussion<p>Bmi1^−/− mice exhibit increased mitochondrial damage, increased oxidative stress, and significant changes in protein markers related to mitophagy compared to WT mice. …”

Table 1_Complement activation drives the phagocytosis of necrotic cell debris and resolution of liver injury.xlsx by Sofie Vandendriessche (638514)

“…Importantly, C3 deficiency led to a significant accumulation of necrotic debris and impairment of liver recovery in mice, which was attributed to decreased phagocytosis of debris by recruited neutrophils in vivo. …”

Table 1_Horticultural performance and QTL mapping of snap bean (Phaseolus vulgaris L.) populations with organic and conventional breeding histories.xlsx by Hayley E. P. Richardson (21383333)

“…We also found that root branching density increased among organically-bred bean families, while root disease decreased in both the organically-bred bean families and the populations with ‘OR5630’ × ‘Black Valentine’ parentage. …”

Table 1_Changes in white matter microstructure in the brain of patients with inflammatory bowel disease are associated with abdominal pain.docx by Lingqin Zhang (12208919)

“…</p>Results<p>Compared with healthy controls, patients with inflammatory bowel disease presented decreased mean diffusivity, axial diffusivity, and radial diffusivity in multiple white matter regions (p < 0.05, corrected). …”

Image 6_Bmi1 deficiency exacerbates hyperoxia-induced acute lung injury in mice.tif by Helena Hernández-Cuervo (9956465)

“…</p>Results<p>Mice lacking Bmi1 versus WT exposed to hyperoxia exhibited hallmarks of human acute lung injury (ALI) such as increased lung permeability, alveolar edema, hemorrhage, interstitial thickening, and infiltration of immune cells; and alterations in lung mechanics, including increased elastance and decreased lung compliance.</p>Discussion<p>Bmi1^−/− mice exhibit increased mitochondrial damage, increased oxidative stress, and significant changes in protein markers related to mitophagy compared to WT mice. …”

Data Sheet 1_Global, regional, and national burden of hyperglycemia-associated colorectal cancer, 1990-2021: a systemic analysis for the Global Burden of Disease study.zip by Yijuan Liu (5195747)

“…Notably, while mortality-related burdens slightly decreased in high-SDI areas, YLDs continued to rise, indicating unmitigated disability burdens. …”

Image 5_Bmi1 deficiency exacerbates hyperoxia-induced acute lung injury in mice.tif by Helena Hernández-Cuervo (9956465)

“…</p>Results<p>Mice lacking Bmi1 versus WT exposed to hyperoxia exhibited hallmarks of human acute lung injury (ALI) such as increased lung permeability, alveolar edema, hemorrhage, interstitial thickening, and infiltration of immune cells; and alterations in lung mechanics, including increased elastance and decreased lung compliance.</p>Discussion<p>Bmi1^−/− mice exhibit increased mitochondrial damage, increased oxidative stress, and significant changes in protein markers related to mitophagy compared to WT mice. …”

Table 3_Association between lactate/albumin ratio and 28-day mortality in ICU critical patients with coronary heart disease: a retrospective analysis of the MIMIC-IV database.pdf by Ying Liu (18461)

“…Both elevated lactate levels and decreased albumin levels may reflect the body's stress response and inflammatory reaction. …”

Table 2_Mortality and trends of pulmonary arterial hypertension, 1990–2021: a population-based study.docx by Linhong Jiang (5004347)

“…Of note, there were significant health inequalities across 204 countries and territories, with the slope index of inequality rising over time. …”