Table 3_Inequalities and age-period-cohort effects of global and regional burden for interstitial lung disease and pulmonary sarcoidosis: based on Global Burden of Disease study 20... by Lei Zhang (38117)

“…Background<p>Interstitial lung disease (ILD) and pulmonary sarcoidosis pose significant disease burdens on a global scale.</p>Methods<p>The underlying data was derived from the Global Burden of Disease (GBD) 2021 database. …”

Table 6_Cardiac energy metabolic disorder and gut microbiota imbalance: a study on the therapeutic potential of Shenfu Injection in rats with heart failure.csv by Zhenyu Zhao (737165)

“…</p>Results<p>Myocardial energy metabolism in HF rats was disordered, characterized by reduced fatty acid oxidation, enhanced anaerobic glycolysis of glucose, mitochondrial damage, and decreased ATP content; The gut microbiota of HF rats was imbalanced, with a reduction in beneficial bacteria, an increase in conditional pathogenic bacteria, and impaired intestinal barrier function; Both Shenfu Injection and trimetazidine improved myocardial energy metabolism and cardiac function, but Shenfu Injection was more significant in regulating gut microbiota and improving intestinal health; The production of SCFAs from the gut microbiota of HF rats increased, which may be closely related to myocardial energy metabolism; SCFAs-producing bacteria Akkermansia and Blautia played a key role in the development of HF, and their abundance was positively correlated with SCFAs content.…”

Supplementary file 2_Heterogeneity and longitudinal transcriptomic characteristics of Tregs in COVID-19 patients.pdf by Yanling Wen (552195)

“…</p>Results<p>Our analysis revealed that the proportion of CCR7⁺ Tregs decreased as the disease advanced, while the cell proportion of HLA_DR⁺ regs escalated with the severity of the disease. …”

Table 1_Biliary microbiota in disease-free, obstructive and post-drainage biliary tracts.docx by Guiyuan Zhang (13994877)

“…Notably, biliary drainage was found to alter the composition of bile microbiota, resulting in decreased microbial diversity and an association with an increase in antibiotic resistance genes.…”

Data Sheet 1_High humidity environment increases FBG by impairing the intestinal barrier.zip by Yao Wang (102387)

“…Introduction<p>Climate and environmental changes pose significant threats to human metabolic health; however, the specific effects of individual environmental factors on metabolic diseases remain poorly understood. …”

Data Sheet 6_Lathyrol inhibits the proliferation of Renca cells by altering expression of TGF-β/Smad pathway components and subsequently affecting the cell cycle.xlsx by Shengyou Song (22391068)

“…The TGF-β/Smad signaling pathway plays a significant role in the development and progression of RCC.…”

Image 3_Global, regional, and national burden of acute glomerulonephritis from 1990 to 2021 and future trend predictions until 2036: a systematic analysis using the Global Burden o... by Yangtian Jiao (21725018)

“…</p>Conclusion<p>Despite significant global progress, disparities persist, particularly in low- and middle-income regions. …”

Data Sheet 1_Global, regional, and national burdens of pancreatitis in children and adolescents aged 0–24 years from 1992 to 2021: a trend analysis based on the global burden of di... by Ying-han Deng (21604157)

“…Background<p>The younger onset of pancreatitis presents a significant public health challenge. This study aims to analyze the global burden of pancreatitis in younger populations based on the Global Burden of Disease 2021.…”

DataSheet3_Primary ovarian insufficiency consequence of autoimmune diseases: a bidirectional two-sample Mendelian randomization study.pdf by Yongming Du (807059)

“…</p>Conclusion<p>This comprehensive MR analysis indicated that SLE, CeD, vitiligo, and AD caused an increased risk of POI, SIgAD was associated with a decreased risk of POI. These insights carry profound clinical implications, particularly emphasizing the early intervention for women with AIDs/POI who wish to preserve their reproductive potential or plan for future pregnancies.…”

Image 2_Moderate regular physical exercise can help in alleviating the systemic impact of schistosomiasis infection on brain cognitive function.tif by Inssaf Berkiks (15350248)

“…Remarkably, exercise decreased glial cell production of TNFα, suggesting a shift towards a less pro-inflammatory environment. …”

Table 3_PitNET tissue deconvolution: tracing normal tissue residues and immune dynamics.xlsx by Mattia Dalle Nogare (22696022)

“…</p>Results<p>CIBERSORTx demonstrated the highest sensitivity (r > 0.85) for detecting pituitary cell types, although accuracy decreased for TME components. Application to ten GH-secreting PitNETs with known histological contamination and to public datasets consistently revealed residual normal tissue across hormone-secreting subtypes, excluding silent tumors. …”

Data Sheet 1_Uncovering the heterogeneity of NK cells on the prognosis of HCC by integrating bulk and single-cell RNA-seq data.csv by Jiashuo Li (7865036)

“…Immunohistochemistry showed that HRG expression was decreased in HCC compared to normal tissues, whereas TUBA1B expression was elevated in HCC.…”

Data Sheet 1_Home-field advantage effect weakened over time but was strengthened by labile carbon input in later litter decomposition stage.doc by Yafang Xue (3775912)

“…Glucose (labile C) was added to soil after decomposition of 4 months. The HFA effect decreased over time, and the fungal community dissimilarity between home and away soils, especially Eurotiomycetes, affected variations in HFA. …”

Supplementary Material for: Phosphorus restriction prevents rapamycin-induced kidney damage in rats by Raya A.I. (19823163)

“…Rapamycin-induced kidney damage is more evident in rats that already have decreased renal function and seems to be related to the phosphaturic effect of the drug. …”

Table 1_Efficacy of the early start Denver model combined with the TEACCH program in children with autism spectrum disorder.docx by Ling-Ling Ma (7894544)

“…Post-treatment ATEC scores decreased from 84.56 ± 20.90 to 68.76 ± 17.96 versus 92.84 ± 18.20 to 84.91 ± 17.50 in controls (between-group difference = 16.32 ± 4.35; P < 0.001; Hedges’ g = 0.45). …”

Data Sheet 1_Unraveling the anti-inflammatory effects of Mediterranean diet in patients with cancer remission.pdf by Michele Francesco Di Tolla (12503167)

“…After dietary intervention, a significant reduction in specific inflammatory and metabolic biomarkers was observed, with distinct effects depending on tumor type. …”

Dynamic visualization of DNA methylation in cell cycle genes during iPSC cardiac differentiation by Ning Li (45258)

“…<p>Existing analyses with conventional assays have generated significant insights into static states of DNA methylation but were unable to visualize the dynamics of epigenetic regulation.…”

DataSheet2_Deficiency of autism susceptibility gene Trio in cerebellar Purkinje cells leads to delayed motor impairments.zip by Jinxin Wang (1696837)

“…The decreased expression of Calbindin existed in both 12-week and 20-week old mice compared with control. …”

<b>Relationship between </b><b>plant</b><b> </b><b>anatomical </b><b>traits and yield among </b><b>different</b><b> winter wheat genotypes in</b><b> </b><b>dry environment</b><b>s<... by Du (17111761)

“…Our results suggests that larger root xylem area, decreased root cortical tissue with lower root respiration, higher abaxial stomatal density with smaller but more stomata in the flag leaf have contributed to increased yields in dry environments. …”

Image3_Seawater temperature drives the diversity of key cyanobacteria (Synechococcus and Prochlorococcus) in a warming sea.tiff by Alexandra Coello-Camba (6489533)

“…<p>The picocyanobacteria genera Prochlorococcus and Synechococcus play a significant role globally, dominating the primary production in warm and oligotrophic tropical and subtropical areas, which represent the largest oceanic ecosystem. …”