Efficacy and safety of aldafermin in non-alcoholic steatohepatitis: A systematic review and meta-analysis of randomized controlled trials by Mohamed Mahmoud Marey (18560902)

“…Aldafermin showed a dose-dependent improvement in the ≥30 % reduction in the liver fat content (RR: 2.16, 95 % CI [1.41 to 3.32]) and (RR: 5.00, 95 % CI [1.34 to 18.64]), alanine aminotransferase levels (MD: −19.79, 95 % CI [−30.28 to −9.3]) and (MD: −21.91, 95 % CI [−29.62 to −14.21]), aspartate aminotransferase levels (MD: −11.79, 95 % CI [−18.06 to −5.51]) and (MD: −13.9, 95 % CI [−18.59 to −9.21]), and enhanced liver fibrosis score (ELF) (MD: −0.13, 95 % CI [−0.29 to 0.02]) and (MD: −0.33, 95 % CI [−0.50 to −0.17]), in the 1 mg and 3 mg subgroups respectively. No significant differences were detected in the aldafermin group regarding histologic endpoints, lipid profile, metabolic parameters, and overall adverse effects, except for the increased occurrence of diarrhea in the aldafermin 3 mg subgroup.…”

Deep Learning for the Accurate Prediction of Triggered Drug Delivery by Husseini, Ghaleb

“…The need to mitigate the adverse effects of chemotherapy has driven the exploration of innovative drug delivery approaches. …”
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Inappropriate Medication Use in Elderly Lebanese Outpatients by Saab, Yolande B.

“…Factors predicting potentially inappropriate drug intake included female sex (65.7% vs 53.3% for males, p = 0.03) and alcohol intake (p = 0.007). There were also significant associations between the likelihood of use of an inappropriate drug and (i) increased number of medical illnesses (p < 0.00002); and (ii) consumption of an over-the-counter drug (OTC) and/or prescription drug (p = 0.048 and p = 0.0035, respectively). …”
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Dissecting the signaling pathways regulating the vascular endothelial growth factor (VEGF) in brain tumor cells. (c2017) by Nicolas, Samer Michel

“…Moreover, when the astrocytoma cells were subjected to hypoxia at different times, we detected a significant increase in pERK. So, in order to confirm that the MAPK pathway is involved in VEGF expression, we added the MAPK inhibitor U0126 to these cells. …”
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Sustainable Detoxification of Methylene Blue in Wastewater via Tea Residue Adsorption: Optimization and Kinetics by Farah F. Salameh (21797300)

“…Contact time showed a stable effect, and increasing the dosage enhanced MB adsorption. …”

Estimating the Impact of Combined Horizontal and Vertical Curves on Drivers’ Perception by Alozn, Mohammad Essam

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Cost and Sustainability Optimization of Desalinated Water Supply Chains by Freihat, Sami Taher

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Evaluation of light-activated Ru(II) prodrugs and their photoproducts as potential anti-cancer agents by Elias, Maria

“…Cytotoxicity assays on A375 showed a mean phototoxicity index of 340 at 72 hours, presenting the intracellular aquated photoproducts being effective rather than the dissociating ligands. A significant increase in ROS production and DNA damage was also observed. …”
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Optimizing pain management and pupil dilation in cataract surgery: a systematic review and meta-analysis of phenylephrine/ketorolac (OMIDRIA®) by Mohamed Abo Zeid (20020680)

“…Data were synthesized using meta-analysis with fixed and random-effects models, and heterogeneity was assessed using the I² statistic.…”

Comparative cost assessment of sustainable energy carriers produced from natural gas accounting for boil-off gas and social cost of carbon by Mohammed Al-Breiki (14152476)

“…<p dir="ltr">As a result of particular locations of large-scale energy producers and increases in energy demand, transporting energy has become one of the key challenges of energy supply. …”

YOLO-DefXpert: An Advanced Defect Detection on PCB Surfaces Using Improved YOLOv11 Algorithm by Prabu Selvam (22330264)

“…<p dir="ltr">Surface defects in Printed Circuit Boards (PCBs), which arise during manufacturing, significantly impact product quality and directly influence equipment performance, stability and reliability. …”

Promising approaches for controlled pulmonary drug delivery by Nature Research (16552612)

“…They, too, enhance the bioavailability of delivered drugs, and also prolong their therapeutic effects. Similarly, nano- and microparticles made of natural or synthetic polymers increase bioavailability and, being biocompatible, 1 they also minimize toxicity. …”

Developing an Urban Resilience Index for Ajman City by ALSHAMSI, ALYA

“…A 17-item universal resilience indicator composite was developed and found to be effective in assisting policymakers with the planning and assessment of a resilient future Ajman. …”
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In vitro regulation of quorum sensing in Pseudomonas aeruginosa using synthetic autoinducers By Hrag Dilabazian A thesis by Dilabazian, Hrag

“…The inducing ability of OdDHL and BHL on the lasB gene was tested under different conditions: by increasing cell density or manipulating the concentration of or time of exposure to autoinducers, revealed that induction was not possible in elastase negative strains and had no detectable effect on the elastase positive strains. …”
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Hydroxyurea Use in Lebanese Patients With [beta]-Thalassemia Intermedia by Taher, Ali

“…We defined therapy to be effective if there was an increase in Hb of at least 1 g/dL because this was correlated in other studies with symptomatic improvement. …”
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The Role of DJ-1 in the Glycation Process of Skin and Plasma Proteins in Mice Models by Abou Younes, Nour

“…Therefore, our findings propose that DJ-1 might be upregulated by a significant increase in carbonyl stress in a time dependent manner, further contributing to the preexisting literature about the deglycase activity of DJ-1. …”
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Pt-doped armchair graphene nanoribbon as a promising gas sensor for CO and CO₂: DFT study by Ehab Salih (17075206)

“…After doping, the results revealed a significant increase in the adsorption energy to almost 9 times than the non-doped systems for the cases of CO on Pt–N-AGNR as well as CO₂ on both Pt–H-AGNR and Pt–N-AGNR. …”

Lipsome-coated metal organic frameworks as a new drug nanocarrier by Mohamed, Omnia A.

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A multi-targeted approach to identify potential flavonoids against three targets in the SARS-CoV-2 life cycle by Sanjay Kumar (8853)

“…To identify the most promising bioactive flavonoids against the SARS-CoV-2, this article screened a virtual library of 46 bioactive flavonoids against three promising targets in the SARS-CoV-2 life cycle: human TMPRSS2 protein, 3CLpro, and PLpro. By examining the effects of glycosylation and other structural-activity relationships, the presence of sugar moiety in flavonoids significantly reduces its binding energy. …”

RFX3 is essential for the generation of functional human pancreatic islets from stem cells by Bushra Memon (4792767)

“…Despite a significant reduction in the expression levels of pancreatic islet hormones, the pan-endocrine marker chromogranin A remained unchanged at both EP and islet stages, likely due to an increase in the abundance of enterochromaffin cells (ECs). …”