The Paget's disease of bone risk gene <i>PML</i> is a negative regulator of osteoclast differentiation and bone resorption by Sachin Wani (11704868)

“…The differentiation, survival and resorptive activity of osteoclasts prepared from Pml−/− mice was increased compared with wild type. Furthermore, the inhibitory effect of IFN-γ on osteoclast formation from Pml−/− was significantly blunted compared with wild type. …”

A numerical model for the solution of thermal elastohydrodynamic lubrication in coated circular contacts by Habchi, Wassim

“…These effects increase with coating's thickness.…”
Get full text
Get full text
Get full text

Aortic stiffness, living donors, and renal transplantation by Bahous, Sola Aoun

“…In subjects with renal disease, reduced renal function and increased arterial stiffness are significantly associated in cross-sectional studies. …”
Get full text
Get full text
Get full text
Get full text

High phosphorus diet mitigates impairments in lipid and glucose metabolism associated with diet-induced obesity in male sprague dawley rats by Bassil, Maya

“…High fat induced obesity significantly (p<0.05) increased serum cholesterol, triglycerides and ALP in HF group (46.1±3.9mg/dl, 38.8±4.4mg/dl and 192.8±55.9U/l, respectively) compared to control (19.8±2.7mg/dl, 26.0.1±3.7mg/dl and 76.6±7.3U/l, respectively) but P supplementation in HFHP prevented this increase. …”
Get full text
Get full text
Get full text

Urtica dioica seed extracts. (c2007) by Halabi, Marwan Iskandar

Get full text
Get full text

Divergent Biochemical Properties and Disparate Impact of Arrhythmogenic Calmodulin Mutations on Zebrafish Cardiac Function by Sahar I. Da'as (17128747)

“…Expression of CaM^D132E and CaMD134H mutants results in significant reduction of the zebrafish heart rate, mimicking a severe form of human bradycardia, whereas expression of CaM^Q136P results in an increased heart rate mimicking human ventricular tachycardia. …”

Acute exposure to cigarette smoking followed by myocardial infarction aggravates renal damage in an In vivo mouse model by Kobeissy, Firas

“…Finally, reactive oxygen species (ROS) production was significantly accentuated in S+MI group concomitant with a significant increase in NOX-4 protein levels. …”
Get full text
Get full text
Get full text
Get full text

AI Integration Within the Architectural Design Process and Management, and its Influence on Project Agility: A Literature Review, Bibliometric, and Survey Analysis by MANSOUR, ABDULHAK N

“…The findings reveal that AI integration significantly enhances project agility and outcomes, primarily through increased design creativity and automation in project management. …”
Get full text

Efficiency of commercial banks in Lebanon by Djoundourian, Salpie

“…The stochastic production and cost function estimates show that bank level inefficiency effects decreases with time and increases with number of branches, employees per branch, and ratio of staff to operating expenses.…”
Get full text
Get full text
Get full text
Get full text

A novel inhibitor of STAT3 activation is efficacious against established central nervous system melanoma and inhibits regulatory T cells by Abou-Ghazal, Mohamed K.

“…Although WP1066 did not induce immunological memory or enhance humoral responses to EGFRvIII, this compound reduced the production of immunosuppressive cytokines and chemokines (TGF-β, RANTES, MCP-1, VEGF), markedly inhibited natural and inducible Treg proliferation, and significantly increased cytotoxic immune responses of T cells. …”
Get full text
Get full text
Get full text
Get full text

A novel inhibitor of signal transducers and activators of transcription 3 activation is efficacious against established central nervous system melanoma and inhibits regulatory T ce... by Abou-Ghazal, Mohamed

“…Although WP1066 did not induce immunologic memory or enhance humoral responses to EGFRvIII, this compound reduced the production of immunosuppressive cytokines and chemokines (transforming growth factor-β, RANTES, MCP-1, vascular endothelial growth factor), markedly inhibited natural and inducible Treg proliferation, and significantly increased cytotoxic immune responses of T cells. …”
Get full text
Get full text
Get full text
Get full text

Ethnic-specific association of amylase gene copy number with adiposity traits in a large Middle Eastern biobank by Niccolo’ Rossi (14152692)

“…Indeed, lower AMY1 CN was associated with increased total and trunk fat percentages in Arabs (P < 4.60 × 10−3) but not in Persians. …”

Anti-cancer Drug Delivery Using Metal Organic Frameworks (MOFs) and Ultrasound. by Ibrahim, Mihad

Get full text

The Use of Transferrin and Ultrasound in Cancer Treatment by AlSawaftah, Nour Majdi

Get full text

Chronic carob molasses intake and its impact on blood lipemia and glycemia in the rat model. (c2007) by Nassar, Issam Yaacoub

Get full text
Get full text

Nicotine induces resilience to chronic social defeat stress in a mouse model of water pipe tobacco exposure by activating BDNF signaling by Khalifeh, Mohamad

“…Even though WTS initially decreased anxiety-like behaviors, prolonged exposure after the completion of CSDS significantly induced anxiety-like behaviors. Finally, we showed that nicotine mediates the effects of WTS only on resilience to stress by increasing BDNF and TRKB levels and signaling. …”
Get full text
Get full text
Get full text
Get full text

Toxicity assessment of di(2-ethylhexyl) phthalate using zebrafish embryos: Cardiotoxic potential by Azza, Naïja

“…They are added to plastics to increase their flexibility and softness. Phthalate plasticizers including the Di-2-ethylhexyl phthalates (DEHP) are toxic and induce adverse effects on the different organization levels of the environment. …”
Get full text
Get full text
Get full text

20-HETE and EETs in Diabetic Nephropathy: A Novel Mechanistic Pathway by Stephanie Eid (440990)

“…In conclusion, we show that hyperglycemia in diabetes has a significant effect on the expression of Arachidonic Acid (AA)-metabolizing CYPs, manifested by increased AA metabolism, and might thus alter kidney function through alteration of type and amount of AA metabolites.…”

Pleiotropic functions of the tumor- and metastasis-suppressing matrix metalloproteinase-8 in mammary cancer in MMTV-PyMT transgenic mice by Julie Decock (44558)

“…Throughout the 14 weeks of the model, tumor burden increased in homozygous Mmp8-null mice compared to Mmp8-wild-type and -heterozygote animals. …”

12/15-Lipoxygenase-Derived Lipid Metabolites Induce Retinal Endothelial Cell Barrier Dysfunction: Contribution of NADPH Oxidase by Amira Othman (380131)

“…ROS generation and NOX2 expression were also measured in mice retinas. 12- and 15- HETE significantly increased permeability and reduced TER and ZO-1expression in REC. …”