Stromal TRIM28-associated signaling pathway modulation within the colorectal cancer microenvironment حسب Seán Fitzgerald (721911)

"…<h3>Background</h3><p dir="ltr">Stromal gene expression patterns predict patient outcomes in colorectal cancer. …"

Proteomic insight towards key modulating proteins regulated by the aryl hydrocarbon receptor involved in ovarian carcinogenesis and chemoresistance حسب Lubna Therachiyil (4246156)

"…We have previously reported that exposure of OC cells to TCDD, an AhR activator, significantly modulated the expression of several genes that play roles in stemness and chemoresistance. …"

Physiological and pharmacological stimulation for in vitro maturation of substrate metabolism in human induced pluripotent stem cell-derived cardiomyocytes حسب Colleen A. Lopez (18520071)

"…We have investigated substrate metabolism in hiPSC-CMs grown as a monolayer and in 3D, in porous collagen-derived scaffolds and in engineered heart tissue (EHT), by measuring rates of glycolysis and glucose and fatty acid oxidation (FAO), and changes in gene expression and mitochondrial oxygen consumption. …"

p53 Inhibition in Pancreatic Progenitors Enhances the Differentiation of Human Pluripotent Stem Cells into Pancreatic β-Cells حسب Idil I. Aigha (14913774)

"…Interestingly, overexpression of NKX6.1 in hESC-MPCs enhanced the expression of key MPC genes and dramatically suppressed p53 expression. …"

Description of PTPRG genetic variants identified in a cohort of Chronic Myeloid Leukemia patients and their ability to influence response to Tyrosine kinase Inhibitors حسب Mohamed A. Ismail (418629)

"…</p><h2>Other Information</h2><p dir="ltr">Published in: Gene<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.gene.2021.146101" target="_blank">https://dx.doi.org/10.1016/j.gene.2021.146101</a></p>…"

BCL-2 Inhibitor Venetoclax Induces Autophagy-Associated Cell Death, Cell Cycle Arrest, and Apoptosis in Human Breast Cancer Cells حسب Ali Alhoshani (3720718)

"…This effect was associated with a significant increase in the percentage of apoptotic MDA-MB-231 cells and in the expression of the apoptotic genes, caspase 3, caspase 7, and BAX, with inhibition of antiapoptotic gene, BCL-2 levels. …"

The Cancer Spliceome: Reprograming of Alternative Splicing in Cancer حسب Ettaib El Marabti (23276158)

"…<p dir="ltr">Alternative splicing allows for the expression of multiple RNA and protein isoforms from one gene, making it a major contributor to transcriptome and proteome diversification in eukaryotes. …"

Tumor-Infiltrating Lymphoid Cells in Colorectal Cancer Patients with Varying Disease Stages and Microsatellite Instability-High/Stable Tumors حسب Salman M. Toor (8854751)

"…Lastly, The Cancer Genome Atlas Colon Adenocarcinoma datasets showed associations between low expression of selective genes and poorer progression-free interval. …"

Urtica dioica extract and its impact on blood lipids, glycemia & inflammation in the rat model. (c2005) حسب Baroudy, Karmen George

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Phenol sulfotransferases حسب Nasser, Selim M.

"…In recent years, significant effort has been made to identify genes that influence breast cancer risk. …"
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PD-L1 Blockade by Atezolizumab Downregulates Signaling Pathways Associated with Tumor Growth, Metastasis, and Hypoxia in Human Triple Negative Breast Cancer حسب Reem Saleh (3513056)

"…Gene set enrichment analyses revealed that a significant number of these genes are related to the NF-kB, PI3K/Akt/mTOR, MAPK, and CD40 signaling pathways. …"

Pleiotropic functions of the tumor- and metastasis-suppressing matrix metalloproteinase-8 in mammary cancer in MMTV-PyMT transgenic mice حسب Julie Decock (44558)

"…Using quantitative real-time RT-PCR, we tracked the expression of the entire Mmp and Timp gene families, observing a significant decrease in Mmp3 expression in Mmp8-null tumors compared to wild-type and heterozygotes throughout the time course of the model, which was confirmed at the protein level. …"

A Comprehensive Method of Ion Exchange Resins Regeneration and Its Optimization for Water Treatment حسب Al-Asheh, Sameer

"…The strong acidic cation polymeric exchanger resin is commercially called MERCK 104765 cation exchanger IV with capacity greater than 3.2 mmol/ml, while the strong basic anion polymeric exchanger resin is commercially called MERCK 104767 anion exchanger III with capacities greater than 1.0 mmol/ml. …"
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Aqueous urtica dioica leaves extract inhibits proliferation of acute myeloid leukemia cells in vitro حسب Rizk, Sandra

"…With respect to the proteins studied, treatment with Urtica dioica extract significantly increased the expression of the pro-apoptotic protein Bax with concomitant decrease in the anti-apoptotic protein Bcl-2 expression. …"
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Internet Searches for Medical Symptoms Before Seeking Information on 12-Step Addiction Treatment Programs: A Web-Search Log Analysis حسب George Nitzburg (18614989)

"…Second, we examined symptom queries preceding queries on the 12-step program at time lags of 0-7 days, 7-14 days, and 14-30 days, where the probability of asking about a medical symptom was greater in the 30-day time window preceding 12-step program information-seeking as compared to all previous times that the symptom was queried.…"

Whole-genome sequencing based molecular characterization of multi-drug resistant isolates of Enterobacter spp. and Klebsiella aerogenes in Lebanon. (c2019) حسب Merhi, Georgi S.

"…One blaCTX-M-15 positive ECC isolate had the ESBL gene integrated in the chromosome through an ISEcp1-blaCTX-M-15-orf477Δ transposition unit, while a second extremely resistant ECC isolate coharbored blaNDM-1 and blaCTX-M-15. …"
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Protocadherin of the liver, kidney and colon associates with detergent-resistant membranes during cellular differentiation حسب Rizk, Sandra

"…Here, we demonstrate that the expression of PLKC at the apical membrane domain and its concentration at regions of cell-cell contacts occur concomitantly with significant elevation of PLKC-mRNA levels. …"
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Epigenetic analysis of Paget’s disease of bone identifies differentially methylated loci that predict disease status حسب Ilhame Diboun (3522413)

"…Meta-analysis of data from the discovery and cross-validation set, each comprising 116 PDB cases and 130 controls, revealed significant differences in DNA methylation at 14 CpG sites, 4 CpG islands, and 6 gene-body regions. …"

Immune Checkpoints in Circulating and Tumor-Infiltrating CD4+ T Cell Subsets in Colorectal Cancer Patients حسب Salman M. Toor (8854751)

"…Additionally, tumor-infiltrating CD4⁺ T cells upregulated programmed cell death protein-1 (PD-1), cytotoxic T-lymphocyte-associated protein-4 (CTLA-4), T cell immunoglobulin and mucin domain-3 (TIM-3) and lymphocyte-activation gene 3 (LAG-3). We also characterized the expression of PD-1, CTLA-4, TIM-3, and LAG-3 on different CD4⁺FoxP3^−/+Helios^−/+ T cell subsets. …"

The Impact of a Computerized Potassium Alert on Adverse Drug Events and Pharmacists' Interventions حسب Mansour, Hanine

"…Conclusions: Implementation of a computerized pharmacy alert resulted in a statistically significant decrease in adverse drug events related to hyperkalemia in our institution. …"
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