Cold responses and hormonal echoes: a comprehensive view of Raynaud’s vascular dysfunction by Manal Fardoun (16328847)

“…Indeed, estrogen plays a fundamental role in potentiating the expression and function of α2C adrenoceptor (α2C-AR), the sole mediator of local cooling-induced vasoconstriction. …”

A Multidecadal Assessment of Haze Development and Fluctuations in Visibility for Arabian Peninsula by Luqman Atique (16036586)

“…The daily visibility of QTR exhibits significant variations from 1975 to 2023, with the lowest and greatest values representing the dynamic character of visibility in the region. …”

Dynamic Hybrid Cross-Docking Model with Multiple Truck Types by Holla, Sitara

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Deciphering the In vitro Role of microRNAs miR-21-3p and miR-222-5p In the Regulation of Clostridioides difficile Flagellin-Induced Inflammation by Salman, Zeina

“…Quantitative PCR revealed that FliC stimulation upregulated miR-222-5p and miR-21-3p expression within 2 hours of treatment. Functional assays revealed that miR-222-5p overexpression led to a significant increased expression of key pro-inflammatory cytokines, including IL-8 and TNF-α, while knockdown of these miRNAs resulted in their decreased expression. …”
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Comparative Study on Beneficial Effects of Hydroxytyrosol- and Oleuropein-Rich Olive Leaf Extracts on High-Fat Diet-Induced Lipid Metabolism Disturbance and Liver Injury in Rats by Ines Fki (14571855)

“…The hepatic immunohistochemical analysis revealed a significant increase in the expression of inflammatory genes (COX-2, NF-<em>κ</em>B, and TNF-<em>α</em>). …”

Physiological and pharmacological stimulation for in vitro maturation of substrate metabolism in human induced pluripotent stem cell-derived cardiomyocytes by Colleen A. Lopez (18520071)

“…We have investigated substrate metabolism in hiPSC-CMs grown as a monolayer and in 3D, in porous collagen-derived scaffolds and in engineered heart tissue (EHT), by measuring rates of glycolysis and glucose and fatty acid oxidation (FAO), and changes in gene expression and mitochondrial oxygen consumption. FAO was stimulated by activation of peroxisome proliferator-activated receptor alpha (PPARα), using oleate and the agonist WY-14643, which induced an increase in FAO in monolayer hiPSC-CMs. hiPSC-CMs grown in 3D on collagen-derived scaffolds showed reduced glycolysis and increased FAO compared with monolayer cells. …”

Synthetic Cannabinoid AB-FUBINACA Negatively Impacted the Male Fertility and Induced Testicular Toxicity by Ayman Alzu’bi (13162392)

“…These findings were associated with higher level of oxidative stress (GP91 expression and malondialdehyde level) and elevated expression of key regulators of apoptosis (Bax and caspase-3) as well as reduced expression of mitochondrial respiratory chain complexes SDHB (II), UQCRC2 (III), and ATP5a (V) in the testicular tissue.…”

Role of microRNA 690 in Mediating Angiotensin II Effects on Inflammation and Endoplasmic Reticulum Stress by Kalhara R. Menikdiwela (18566698)

“…Small RNA sequencing and microarray in WAT identified differentially expressed miRNAs and genes, out of which miR-690 and mitogen-activated protein kinase kinase 3 (MAP2K3) were validated as significantly up- and down-regulated, respectively, in Agt-Tg, and in Ang II-treated adipocytes compared to respective controls. …”

Interleukin-35 and Thymoquinone nanoparticle-based intervention for liver protection against paracetamol-induced liver injury in rats by Maisa Siddiq Abduh (16381125)

“…Furthermore, significant downregulation of IL1-β, TNF-α, TGF-β, and Caspas-3 genes, as well as significant upregulation of Bcl-2 and IL-10 expression were detected. …”

PD-L1 Blockade by Atezolizumab Downregulates Signaling Pathways Associated with Tumor Growth, Metastasis, and Hypoxia in Human Triple Negative Breast Cancer by Reem Saleh (3513056)

“…<div><p>Triple negative breast cancer (TNBC) is the most aggressive type of breast cancer, which shows resistance to common breast cancer therapies, as it lacks the expression of the most common breast cancer targets. …”

Triple therapy with pravastatin, low molecular weight heparin and low dose aspirin improves placental haemodynamics and pregnancy outcomes in obstetric antiphospholipid syndrome in... by Eleftheria Lefkou (17052414)

“…Addition of pravastatin increase eNOS synthesis, expression and activity/signaling leading to a significant increment in nitric oxide (NO) generation, resulting in improved placental vascular function and total protection of pregnancies.…”

Functional Characterization of Novel <i>MC4R </i>Variants Identified in Two Unrelated Patients with Morbid Obesity in Qatar by Idris Mohammed (751020)

“…In vitro analysis of the functional impact of these variants showed a significant reduction in cell surface receptor expression and impaired extracellular ligand binding activity, leading to reduced cAMP production. …”

Financial development and economic growth under uprisings by Arayssi, Mahmoud

“…Therefore, policies aiming at improving the efficiency and the operation of institutions such as a country’s legal system, citizen’s participation in selecting government, freedom of expression and the stage of financial development should persist over an extended period of time, in order to bear fruition and achieve a significant success in boosting economic growth and reducing poverty.…”
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Gender inequality and cultural values in explaining gender differences in positive and negative emotions: A comparison of 24 countries during the COVID-19 pandemic by Robin Wollast (8344017)

“…The present study investigates the expression of positive and negative emotions during the pandemic as a function of gender and across 24 countries (<i>N </i>= 49,637). …”

The utility of a deep learning-based approach in Her-2/neu assessment in breast cancer by Saidul Kabir (15302407)

“…It is present in 15 to 20% of breast cancers and is clinically significant due to the availability of multiple anti-Her2 treatment options. …”

The utility of a deep learning-based approach in Her-2/neu assessment in breast cancer by Saidul, Kabir

“…It is present in 15 to 20% of breast cancers and is clinically significant due to the availability of multiple anti-Her2 treatment options. …”
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Government and Financial Institutional Determinants of Development in MENA Countries by Arayssi, Mahmoud

“…Therefore, policies aiming at improving the efficiency and the operation of institutions such as a country’s legal system, citizen’s participation in selecting government, freedom of expression, and the stage of financial development should persist over an extended period of time, in order to bear fruition and achieve a significant success in boosting economic growth and reducing poverty.…”
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Leptin is a potential biomarker of childhood obesity and an indicator of the effectiveness of weight‐loss interventions by Mohammad Al Zein (20090700)

“…<p dir="ltr">Childhood obesity represents a significant public health concern, imposing a substantial burden on the healthcare system. …”

Ghost-NeRV: Efficient Neural Video Representation via Ghost Convolutions by Shanableh, Tamer

“…Unlike binarization-based approaches, Ghost-NeRV preserves full-precision computation while significantly reducing the number of floating-point operations and model parameters. …”
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Biochemical Characterization of Halotolerant Bacillus safensis PM22 and Its Potential to Enhance Growth of Maize under Salinity Stress by Muhammad Atif Azeem (17542080)

“…Additionally, inoculation of the halotolerant bacteria PM22 reduced the severity of salinity stress in plants and increased root and shoot length at various salt concentrations (0, 180, 240, and 300 mM). …”