Cathelicidin LL-37-induced transcriptome of human keratinocyte identifies chemokine CXCL10 link to T cell-mediated rosacea pathogenesis via JAK-1/STAT-1 pathway حسب Abdul W. Ansari (14557391)

"…Abnormal overexpression of human antimicrobial peptide LL-37 is a hallmark of rosacea. However, its significance in the rosacea pathogenesis is not fully understood. …"

Aspirin inhibition and recovery of cyclooxygenase activity and thromboxane biosynthesis in human megakaryocytes: a translational surrogate model حسب Zahraa I. Mallah (23125621)

"…We characterized COX-1 and COX-2 expression and activity in MEG-01 and CHRF-288-11 megakaryocytic cell lines, treated with a range of aspirin concentrations and exposure duration. …"

Adipocyte Enhancer-Binding Protein 1 (AEBP1) (a Novel Macrophage Proinflammatory Mediator) Overexpression Promotes and Ablation Attenuates Atherosclerosis in ApoE⁻′⁻ and LDLR⁻′⁻ Mi... حسب Bogachev, Oleg

"…Macrophages from ApoE⁻′⁻/TG-BM chimeric mice express reduced levels of PPARγ₁, LXRα, ATP-binding cassette A₁ (ABCA₁) and ATP-binding cassette G₁ (ABCG₁) and increased levels of the inflammatory mediators interleukin (IL)-6 and tumor necrosis factor (TNF)-α compared with macrophages of control chimeric mice (ApoE⁻′⁻/NT-BM) that received AEBP₁ nontransgenic (AEBP₁ᴺᵀ) BM cells. …"
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The molecular mechanisms of apoptosis accompanied with the epigenetic regulation of the NY-ESO-1 antigen in non-small lung cancer cells treated with decitabine (5-aza-CdR) حسب Varghese P. Inchakalody (14557382)

"…We also observed the differential expression of protein Complement C3 (3.3-fold), Destrin (−5.1-fold), Vimentin (−1.7-fold), Peroxiredoxin 4 (−1.6-fold), Fascin (−1.8-fold), Heme oxygenase-2 (−0.67-fold**p < 0.0055), Hsp27 (−0.57-fold**p < 0.004), and Hsp70 (−0.39-fold **p < 0.001), indicating reduced cell growth, cell migration, and metastasis. …"

Diphtheria toxin-murine granulocyte-macrophage colony-stimulating factor–induced hepatotoxicity is mediated by Kupffer cells حسب Abi-Habib, Ralph J.

"…Furthermore, alternative fusion toxins with potentially reduced hepatotoxicity are presented.…"
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Targeting HER2-positive breast cancer cells by a combination of dasatinib and BMS-202: Insight into the molecular pathways حسب Hadeel Kheraldine (14231609)

"…Moreover, the combination inhibits epithelial-mesenchymal transition (EMT) progression and reduces cancer cell invasion by restoring E-cadherin and β-catenin expressions and loss of vimentin, major biomarkers of EMT. …"

Comparative Transcriptome Analysis Reveals That Exendin-4 Improves Steatosis in HepG2 Cells by Modulating Signaling Pathways Related to Lipid Metabolism حسب Khaoula Errafii (10914446)

"…We compared the transcriptome profiles of untreated steatotic, and Ex-4-treated steatotic cells, and used Ingenuity Pathway Analysis (IPA) to identify the signaling pathways and associated genes involved in the protective effect of Ex-4. Ex-4 treatment significantly reduces steatosis. RNA-seq analysis revealed 209 differentially expressed genes (DEGs) between steatotic and untreated cells, with farnesoid X receptor/retinoid X receptor (FXR/RXR) (p = 8.9 × 10⁻⁷) activation being the top regulated canonical pathway identified by IPA. …"

Dynamic Change in Insulin Resistance Induced by Free Fatty Acids Is Unchanged Though Insulin Sensitivity Improves Following Endurance Exercise in PCOS حسب Myint Myint Aye (6404327)

"…Skewed data were log transformed and expressed as mean ± SEM.</p><h3>Results</h3><p dir="ltr">Before exercise, women with PCOS had a higher HOMA-IR and lower VO2 max than controls. …"

Students Plugged: The Psychological Impact of Smart Devices Screen Time Exposure on Cognitive Concentration Skills in Primary School Students in Abu Dhabi حسب Shorouk Sobh

"…However, high screen exposure was identified as a factor influencing health, correlating with reduced cognitive concentration, while physical activity proved to be a mitigating factor. …"
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A simplified model for unsteady pressure driven flows in circular microchannels of variable cross-section حسب Issa, Leila

"…Compared to classical CFD simulations, the reduced order semi-analytic method is two orders of magnitude faster, owing in part to the fact that the number of modes required for the convergence of these expressions is not too large. …"
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Design analysis and experimental validation of a multi‐level inverter for vehicle to home application حسب Mohd Khalid (681127)

"…The comparison with the existing multi‐level inverter (MLI) topologies and literature shows the significant acceptability and reliability of the proposed multi‐level inverter. …"