Natalizumab Treatment for Relapsing Multiple Sclerosis Stabilises Normal-Appearing White Matter Microstructure: A One-Year Prospective Ultra-High-Field Quantitative Imaging Study حسب Radu Tanasescu (439168)

"…Chemical exchange saturation transfer (CEST) MRI can explore brain tissue in vivo with high resolution and sensitivity. We investigated if natalizumab can prevent microstructural tissue damage progression measured with MRI at ultra-high field (7 Tesla) over the first year of treatment. …"

Evidence and gaps in clinical outcomes of novel pharmacologic therapies for sickle cell disease: A systematic literature review highlighting insights from clinical trials and real-... حسب Mohamed Yassin (4166515)

"…Real-world studies of crizanlizumab showed a reduction in complicated VOC events. The high discontinuation rate and results of the STAND trial led to a significant decrease in the use of crizanlizumab. …"

Spatial, temporal, and demographic patterns in prevalence of chewing tobacco use in 204 countries and territories, 1990–2019: a systematic analysis from the Global Burden of Diseas... حسب Parkes J Kendrick (9714851)

"…Among females, none of these 12 countries had significant decreases in prevalence of chewing tobacco use, whereas seven of 12 countries had a significant decrease in the prevalence of tobacco smoking use for the period. …"

Ultrasonication-based rapid amplification of α-synuclein aggregates in cerebrospinal fluid حسب Keita Kakuda (9668898)

"…Notably, the lag time of patients with Parkinson’s disease was significantly correlated with the MIBG heart-to-mediastinum ratio. …"

IMPACT OF THE UAE NATIONAL SERVICE ON ACADEMIC ACHIEVEMENT AMONG COLLEGE STUDENTS حسب Alhammadi, Fatima

"…The findings have concluded that participation in the national service programme equips young people with experiential and learning skills as well as behavioural maturity improvement that significantly influence their discipline level, academic development, attitudes towards constructive feedback and informed decision-making process. …"
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Moving towards health promoting schools: Effectiveness of an educational intervention to improve knowledge, attitude and beliefs regarding heart attack, and CPR knowledge in high s... حسب Abdelkhalik, Mohamad

"…The intervention significantly increased knowledge, beliefs and attitudes towards heart attack, and knowledge of CPR (p<0.001). …"
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A loss-of-function AGTR1 variant in a critically-ill infant with renal tubular dysgenesis: case presentation and literature review حسب Aljazi Al-Maraghi (14056975)

"…<h3>Background</h3><p dir="ltr">Renal tubular dysgenesis (RTD) is a severe disorder with poor prognosis significantly impacting the proximal tubules of the kidney while maintaining an anatomically normal gross structure. …"

Mortality and associated risk factors of COVID-19 infection in dialysis patients in Qatar: A nationwide cohort study حسب Tarek Abdel Latif Ghonimi (16328413)

"…Univariate Cox regression analysis for risk factors associated with COVID-19-related death  in dialysis patients showed significant increases in risks with age (OR 1.077, CI 95%(1.018– 1.139), p = 0.01), CHF and COPD (both same OR 8.974, CI 95% (1.039–77.5), p = 0.046), history of DVT (OR 5.762, CI 95% (1.227–27.057), p = 0.026), Atrial fibrillation (OR 7.285, CI 95%(2.029–26.150), p = 0.002), hypoxia (OR: 16.6; CI 95%(3.574–77.715), p = <0.001), ICU admission (HR30.8, CI 95% (3.9–241.2), p = 0.001), Mechanical ventilation (HR 50.07 CI 95% (6.4–391.2)), p<0.001) and using inotropes(HR 19.17, CI 95% (11.57–718.5), p<0.001). …"

Mapping subnational HIV mortality in six Latin American countries with incomplete vital registration systems حسب Local Burden of Disease HIV Collaborators (13279180)

"…Despite decreases in national HIV mortality in all countries—apart from Ecuador—across the period of study, we found broad variation in relative changes in HIV mortality at the municipality level and increasing relative inequality over time in all countries. …"

Structural and Biophysical Characterization of Stable Alpha-Synuclein Oligomers حسب Nishant Vaikath (3554687)

"…It has been reported that the brains of deceased patients with PD contain high levels of protein oligomers that are cross-linked to these aldehydes. …"

Pregnancy-related issues in women with multiple sclerosis: an evidence-based review with practical recommendations حسب Beatriz Canibaño (18102676)

"…Pregnancies in MS are not <i>per se</i> high risk pregnancies, and MS does not influence the mode of delivery or anesthesia unless in the presence of significant disability. …"

An examination of how climate change could affect the future spread of Fusarium spp. around the world, using correlative models to model the changes حسب Muhammad Riaz, Ejaz

"…The plant pathogenic fungus Fusarium is known for causing crop diseases like blight, root and stem rots, and wilts, making it the most significant mycotoxigenic genus in weeds and food across various climatic zones worldwide. …"
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Tau- but not Aß -pathology enhances NMDAR-dependent depotentiation in AD-mouse models حسب Enrico Faldini (18602953)

"…<div><p>Many mouse models of Alzheimer’s disease (AD) exhibit impairments in hippocampal long-term-potentiation (LTP), seemingly corroborating the strong correlation between synaptic loss and cognitive decline reported in human studies. …"

The protective effects of conditioned media from human mesenchymal stem cells against Methylglyoxal-mediated injury of cultured endothelial cells حسب Maram Hasan (6672440)

"…We noted that only the mRNA expression of Nrf2 was increased in cells treated with MSCs-CM (50%). At the protein expression level, our results demonstrated that MSCs-CM (50%) enhanced the expression of the detoxifying NQO1in MGO-injured cells.…"

Identification of a Gene Panel Predictive of Triple-Negative Breast Cancer Response to Neoadjuvant Chemotherapy Employing Transcriptomic and Functional Validation حسب Radhakrishnan Vishnubalaji (3563306)

"…Eight RD-derived genes were identified as TNBC-essential genes, which were highly predicative of overall survival (OS) and relapse-free survival (RFS) in an additional cohort of basal breast cancer (n = 442). …"

Mechanisms underlying the effects of caloric restriction on hypertension حسب Ahmad A. Al Attar (17563152)

"…However, the mechanisms behind this effect are not yet fully understood, although an evolving view supports a significant impact of CR on vascular structure and function, specifically at the level of vascular endothelial cells, vascular smooth muscle cells along with their extracellular matrix (ECM). …"

Otosyphilis: A rare case of reversible hearing loss in a young man with secondary syphilis حسب Enas W. Sarsak (17317015)

Arrhythmia-Associated Calmodulin E105A Mutation Alters the Binding Affinity of CaM to a Ryanodine Receptor 2 CaM-Binding Pocket حسب Angelos Thanassoulas (2822861)

Efficacy of Lebanese Cannabis Oil Extract in the Treatment of Folic Acid-Induced Renal Fibrosis in Rats حسب Bylan, Diana

"…Kidney disease is a main contributor to mortality and morbidity worldwide. …"
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16S rRNA Gene-Based Characterization and Functional Profiling of the Microbiome in Young Adults حسب Makhlouf, Rita

"…An increased Proteobacteria level was linked with gut dysbiosis and reported in Type 2 diabetes, metabolic disorders, and Inflammatory Bowel Disease (IBD). …"
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