The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu... حسب Wesal Habbab (17346961)

"…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …"

Machine Learning based Model Reveals the Metabolites Involved in Coronary Artery Disease حسب Fathima Lamya (22565261)

"…The results show that 173 metabolites ( P < .05) are significantly associated with CAD. Of these metabolites, the majority (95/173, 54.91%) were high in CAD patients, while 45.09% (78/173) were high in the control group. …"

Prevalence of non-communicable disease and the associated factors among healthcare workers in Qatar حسب Ayman Al-Dahshan (8962568)

"…<h3>Background</h3><p dir="ltr">Non-communicable diseases (NCDs) significantly impact global health and contribute to economic burdens and premature deaths, with healthcare workers (HCWs) being at high risk. …"

Methylomic profiling in trisomy 21 identifies cognition- and Alzheimer’s disease-related dysregulation حسب Larissa Haertle (3864310)

"…Furthermore, T21 patients have a high risk of developing Alzheimer’s disease (AD) early in life, characterized by the presence of senile plaques of amyloid protein and neurofibrillary tangles, leading to neuronal loss and cognitive decline. …"

Lipid profile in Parkinson's disease: The potential role of brain-derived neurotrophic factor حسب Mahmoud A. Alomari (14780446)

"…Subsequent ANCOVA revealed differences (p < 0.05) in TC, HDL, LDL, TC/LDL, and TriG/HDL but not in glucose, TriG, and TC/HDL among the patients with low-BDNF versus high-BDNF.</p><h3>Significance</h3><p dir="ltr">The results demonstrate a relationship of BDNF with lipid profile suggesting the importance of BDNF for lipid metabolism in PD.…"

Anti-amyloid monoclonal antibody therapies in Alzheimer’s disease – a scoping review حسب Shahd Abubaker Elamin (22569539)

"…<p dir="ltr">Alzheimer’s disease (AD) is a progressive neurodegenerative disorder affecting millions worldwide, and with advancements in the medical field, Anti-amyloid monoclonal antibodies (AA mAbs) targeting amyloid-β have emerged as potential disease-modifying agents altering AD pathology. …"

Mulberry Leaf Disease Detection Using CNN-Based Smart Android Application حسب Abdus Salam (1918387)

"…However, mulberry trees are highly susceptible to diseases, spreading rapidly and causing significant losses. …"

Endocrine contribution to the sexual dysfunction in patients with advanced chronic kidney disease and the role of hyperprolactinemia حسب Haitham Elbardisi (14058048)

"…Patients treated with cabergoline (<i>n</i> = 26) showed a significant increase in LH levels (<i>p</i> = .003) and a significant decrease in prolactin levels (<i>p</i> = .003). …"

EEG-Based Semantic Vigilance Level Classification Using Directed Connectivity Patterns and Graph Theory Analysis حسب Yahya, Fares

"…The strength and directionality of information flow in the connectivity network by RWTE/PDC and the GTA measures significantly decrease with vigilance decrement, p<0.05. …"
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Can the Salivary Microbiome Predict Cardiovascular Diseases? Lessons Learned From the Qatari Population حسب Selvasankar Murugesan (4376506)

"…This study aims to identify whether a predictive salivary microbiome signature is associated with a high risk of developing CVD in the Qatari population.…"

Whole blood DNA aberrant methylation in pancreatic adenocarcinoma shows association with the course of the disease حسب El Maarri, Osman

"…Additionally, high methylation levels at TNFRSCF10C were associated with positive perineural spread of tumor cells, while higher methylation levels of TNFRSF10C and ACIN1 were significantly associated with shorter survival. …"
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Trends of the Dementia Burden in South Asia: An Analysis of 2021 Global Burden of Disease Study حسب Shubham Chauhan (21334742)

"…While prevalence rates experienced a minor decline, Disability‐Adjusted Life Years (DALYs) rose from 272.02 to 308.27 per 100,000, reflecting an increasing burden of the disease. Notably, Nepal significantly reduced its incidence rates, while Pakistan saw an increase in mortality rates. …"

The role of preoperative transfusion in sickle cell disease, a systematic review and meta-analysis حسب Yasamin Abdu (15899155)

"…Further high-quality studies are needed to refine recommendations.…"

Cutting‐edge technologies for detecting and controlling fish diseases: Current status, outlook, and challenges حسب Sk Injamamul Islam (14111241)

"…Early detection of disease is crucial for farmers as mortality rates can reach as high as 100% if left untreated. …"

National-level and state-level prevalence of overweight and obesity among children, adolescents, and adults in the USA, 1990–2021, and forecasts up to 2050 حسب Marie, Ng

"…Without major reform, the forecasted trends will be devastating at the individual and population level, and the associated disease burden and economic costs will continue to escalate. …"
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Myeloid Cells in Circulation and Tumor Microenvironment of Colorectal Cancer Patients with Early and Advanced Disease Stages حسب Salman M. Toor (8854751)

"…We found high levels of granulocytic myeloid cells (GMCs) in whole blood, but their levels were significantly lower in PBMCs. …"

Changes in the burden and underlying causes of heart failure in the Eastern Mediterranean Region, 1990–2019: an analysis of the Global Burden of Disease Study 2019 حسب Razieh, Hassannejad

"…This study provides a systematic analysis of the burden and underlying causes of HF in the EMR, including at the country level, between 1990 and 2019. MethodsWe used the 2019 Global Burden of Disease (GBD) data for estimates of prevalence, years lived with disability (YLDs), and underlying causes of HF in the EMR. …"
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Intravenous administration of gold nanoparticles in rats exhibit alterations in sphingomyelins, bile acids, sphingolipids, and cholesterol esters levels حسب Haya Al-Sulaiti (5449256)

"…Furthermore, treatment with AuNPs caused significant alterations in cholesterol ester levels, essential for lipid storage and transport, indicating disruptions in these mechanisms. …"

Clinical relevance of aortic stiffness in end-stage renal disease and diabetes : implication for hypertension management حسب Bahous, Sola Aoun

"…In treated hypertensive patients, both diabetes and end-stage renal disease (ESRD) are comorbid conditions associated with increased aortic stiffness and high CVR. …"
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Development of a cancer metastasis-on-chip assay for high throughput drug screening حسب Lutfiye Yildiz Ozer (17732619)

"…High-content imaging with automated quantification methods was optimized to assess the tumor cell invasion and intravasation within the model. …"