Data Sheet 2_Immunometabolic alterations in type 2 diabetes mellitus revealed by single-cell RNA sequencing: insights into subtypes and therapeutic targets.csv by Huahua Li (6896339)

“…</p>Results<p>In patients with T2DM, a marked increase in monocytes and a decrease in CD4+ T cells were observed, indicating immune dysregulation. …”

Table2_Asparagus officinalis L. extract exhibits anti-proliferative and anti-invasive effects in endometrial cancer cells and a transgenic mouse model of endometrial cancer.pdf by Ziwei Fang (10115899)

“…Asparagus officinalis extract treatment for 4 weeks resulted in a significant reduction in tumor growth in Lkb1^fl/flp53^fl/fl mice under both obese and lean conditions, with a decrease in Ki-67 and vascular endothelial growth factor expression and an increase in Bip expression in endometrial tumors.…”

Table2_Association of mitochondrial haplogroup H with reduced risk of type 2 Diabetes among Gulf Region Arabs.xlsx by Mohammed Dashti (4849747)

“…</p>Results<p>The analysis revealed a significant protective effect of haplogroup H against T2D (odds ratio [OR] = 0.65; P = 0.022). …”

Image 1_Non-chemotherapy drugs inducing agranulocytosis: a disproportionality analysis based on the FAERS database.pdf by Shanshan Wu (348762)

“…Notably, NCDIA-associated mortality rates showed a significant decrease from 11.91% (2004–2010) to 7.28% (2021–2024) (P < 0.001).…”

Supplementary file 1_Amomum tsao-ko Crevost et Lemarie extract targets the gut-liver axis to combat atherosclerosis in ApoE−/− mice.docx by Qianqian Wang (494839)

“…Serological tests confirmed T-K’s ability to decrease the total serum cholesterol and low-density lipoprotein cholesterol levels. …”

Image 5_Bifidobacterium animalis BD400 protects from collagen-induced arthritis through histidine metabolism.jpeg by Yang Yang (45629)

“…Additionally, there was a decrease in osteo-facial fusion and calcified cartilage thickening in the knee joint. …”

Image 3_Bifidobacterium animalis BD400 protects from collagen-induced arthritis through histidine metabolism.jpeg by Yang Yang (45629)

“…Additionally, there was a decrease in osteo-facial fusion and calcified cartilage thickening in the knee joint. …”

Data Sheet 1_Global, regional, and national burden of acute glomerulonephritis in children and adolescents: 1990–2021 analysis and future projections.docx by Ming Liu (105953)

“…</p>Results<p>From 1990 to 2021, the global burden of AGN among children and adolescents remained significantly high. In 2021, there were approximately 170,584 new cases, representing a decrease compared to earlier years, with an age-standardized incidence rate (ASIR) of 6.47 per 100,000 (95% UI: 4.79–8.45). …”

Data Sheet 1_Deep crustal composition and Late Paleozoic geotectonic evolution in West Junggar, China.pdf by Shenglin Xu (12076840)

“…During the Early Permian-Early Triassic period (272–250 Ma), magmatic activity decreased significantly, where the southwestern region experienced high-temperature, low-pressure, crustal thinning extension. …”

<b>Characterizing the role of PP2AB'' family subunits in mechanical stress response and plant development through calcium and ABA signaling in </b><b><i>Arabidopsis thaliana</i></b... by Hyuk Sung Yoon (19985262)

“…Transcriptome analysis showed a significant decrease in the expression of <i>CYP707A3</i>, a gene potentially targeted by VIP1 that regulates abscisic acid (ABA) catabolism, in the <i>atb''αβγδ</i> mutant compared to wild type leaves. …”

Decadal changes in species composition of rare oak <i>Quercus chungii</i> forests with logging history by Wenbin Li (9244088)

“…A larger contribution from balanced abundance variations than abundance gradient to the temporal <i>β </i>diversity suggested that there was no significant consistent increase or decrease in species abundance during this decade. …”

Data Sheet 3_Immunometabolic alterations in type 2 diabetes mellitus revealed by single-cell RNA sequencing: insights into subtypes and therapeutic targets.csv by Huahua Li (6896339)

“…</p>Results<p>In patients with T2DM, a marked increase in monocytes and a decrease in CD4+ T cells were observed, indicating immune dysregulation. …”

Table 2_The impact of the herd health interventions in small ruminants in low input production systems in Ethiopia.docx by Mesfin Mekonnen Moliso (19920393)

“…Generally, the intervention impact analysis revealed that morbidity rate was significantly decreased (p = 0.009) in intervention years (6.31% in 2018 to 3.02% in 2021) and that herd health interventions provide an added value.…”

DataSheet2_Asparagus officinalis L. extract exhibits anti-proliferative and anti-invasive effects in endometrial cancer cells and a transgenic mouse model of endometrial cancer.pdf by Ziwei Fang (10115899)

“…Asparagus officinalis extract treatment for 4 weeks resulted in a significant reduction in tumor growth in Lkb1^fl/flp53^fl/fl mice under both obese and lean conditions, with a decrease in Ki-67 and vascular endothelial growth factor expression and an increase in Bip expression in endometrial tumors.…”

PTEN KD increases chromatin accessibility. by Ahmed H. Ghobashi (12705573)

“…Red dots indicate peaks with significantly increased or decreased accessibility with Log2 FC > |0.5|. …”

<b>ART does not correct plasma virome and cytokine dysregulations induced by HIV-1</b> by Yingying Ma (18762652)

“…Notably, most cytokines dysregulated were not fully restored by ART, with abnormal levels of IL-10, GM-CSF, VEGF, and eotaxin, and a significantly increased level of plasma I-FABP. Anelloviruses showed significantly negative correlations with other commensal viruses except HPgV-1, but had positive corrections with several anti-inflammatory and Th1 cytokines.…”

Figure 5 from PD-1 Blockade Mitigates Surgery-Induced Immunosuppression and Increases the Efficacy of Photodynamic Therapy for Pleural Mesothelioma by Gwendolyn M. Cramer (16964052)

“…<p>PDT decreases PD-L1 expression and significantly reduces tumor growth after TI. …”

Supporting information_Soil carbon isotopes in global coastal wetlands by Qian Hao (15288697)

“…The results indicated that soil δ¹³C exhibits significant spatial heterogeneity across global coastal wetlands, with values ranging from -21.20‰ to -9.00‰ and decreasing with increasing latitude. …”

Secondary and tertiary outcomes. by Maram Khaled (14642937)

“…Primary outcome is pain intensity with movement (elicited by asking the patient to move from supine to sitting position) using 0–10 Numerical Rating Scale (0 = no pain, 10 = worst possible pain).</p><p>Significance</p><p>The results of this study may result in improved pain control, maternal satisfaction and wound healing; decrease the use of perioperative opioids; potentially decrease the incidence of postpartum depression and persistent pain; and overall lead to better postoperative outcomes thereby decreasing healthcare costs.…”

CONSORT flow diagram. by Maram Khaled (14642937)

“…Primary outcome is pain intensity with movement (elicited by asking the patient to move from supine to sitting position) using 0–10 Numerical Rating Scale (0 = no pain, 10 = worst possible pain).</p><p>Significance</p><p>The results of this study may result in improved pain control, maternal satisfaction and wound healing; decrease the use of perioperative opioids; potentially decrease the incidence of postpartum depression and persistent pain; and overall lead to better postoperative outcomes thereby decreasing healthcare costs.…”