Decoding the Therapeutic Potential of [HuArgI (Co)-PEG5000] Arginase Treatment حسب Zeineddine, Mira

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Long non-coding RNA MALAT1 promotes steatosis in HepG2 cells by modulating target gene expression in presence of Exendin-4 حسب Olfa Khalifa (10914452)

"…</p> <p>Results: Treatment with 200nM Ex-4 for 3h decreased the OA-induced lipid buildup significantly (p<0.05). Concurrently, Ex-4 significantly lowered the expression levels of De novo lipogenesis genes such as SREBP-1, SCD-1and ACC. …"

Loss of FOXA2 induces ER stress and hepatic steatosis and alters developmental gene expression in human iPSC-derived hepatocytes حسب Maryam Aghadi (17128819)

"…Lack of FOXA2 resulted in significant alterations in the expression of key developmental and functional genes in hepatic progenitors (HP) and mature hepatocytes (MH) as well as an increase in the expression of ER stress markers. …"

A comprehensive design and rating study of evaporative coolers and condensers. Part I. Performance evaluation حسب QURESHI, BILAL AHMED

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RFX3 is essential for the generation of functional human pancreatic islets from stem cells حسب Bushra Memon (4792767)

"…This was supported by our findings of high EC marker expression levels in <i>RFX3</i> KO EPs and islets. In addition, RFX3 loss led to smaller islet organoids, elevated thioredoxin-interacting protein levels and increased apoptosis in EPs and islets. …"

A photoactivatable Ru (II) complex bearing 2,9-diphenyl-1,10-phenanthroline حسب Mansour, Najwa

"…A significant increase in cell rounding and detachment, loss of membrane integrity, ROS accumulation and DNA damage was observed. …"
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Transcriptome and Literature Mining Highlight the Differential Expression of ERLIN1 in Immune Cells during Sepsis حسب Susie S. Y. Huang (2824502)

"…Septic stimulation induced a significant increase in ERLIN1 expression; however, ERLIN1 was differentially expressed among the immune blood cell subsets. …"

Squamous Cell Carcinomas of the Head and Neck Cancer Response to Programmed Cell Death Protein-1 Targeting and Differential Expression of Immunological Markers: A Case Report حسب Maysaloun Merhi (4246147)

"…The NY-ESO-1-specific T cells response of the patient was found to be increased after the third and the fifth (**p = 0.002) cycles of treatment but had a significant decline after progression (**p = 0.0028). …"

Transcriptome analysis of Escherichia coli K1 after therapy with hesperidin conjugated with silver nanoparticles حسب Masri, Abdulkader

"…Of note, the expression levels of cation efflux genes (cusA and copA) and translocation of ions, across the membrane genes (rsxB) were found to increase 2.6, 3.1, and 3.3- log FC, respectively. Significant regulation was observed for metabolic genes and several genes involved in the coordination of flagella. …"
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Shear Behavior of One-Way Reinforced Concrete Hollow Slabs Voided with PET Void Formers حسب Hasan, Haider H.

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Exendin-4 promotes GSIS without increasing β-cell number through upregulation of glucose-sensing apparatus and mitochondrial oxidative phosphorylation machinery genes in hPSC-deriv... حسب Abdoulaye Diane (14152749)

"…Interestingly, addition of Exendin-4 (50 nM) during the last 3 days of the differentiation significantly enhanced GSIS associated with increased expression of glucose-sensing apparatus genes (Glut2, G6P2C, GCK) and genes encoding mitochondrial oxidative phosphorylation machinery.…"

Characterization of the Potency and Mechanism of Action of a Novel Dual-Selective Intermolecularly Complemented Version of Anthrax Lethal Toxin (PAU2R200A- PAL1I207R/FP59) in Breas... حسب Basala, Sobhiya

"…PrAg/LF causes cell toxicity, and this motivated the development of a new generation of PrAg variants with increased selectivity. The new version of anthrax, PrAgL1 and PrAgU2 were re-engineered where their activation requires the cleavage by specific tumor associated proteases such as MMPs and uPA/uPAR. …"
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Glycemic outcomes of Advanced Hybrid Closed Loop system in children and adolescents with Type 1 Diabetes, previously treated with Multiple Daily Injections (MiniMed 780G system in... حسب Goran Petrovski (129836)

"…HbA1c decreased from 8.6 ± 1.7% (70 ± 18.6 mmol/mol) at baseline, to 6.5 ± 0.7% (48 ± 7.7 mmol/mol) at the end of the study (<i>p</i> = 0.001). …"

Characterization of the potency and mechanism of action of a novel dual-selective intermolecularly complemented version of Anthrax Lethal Toxin (PAU2R200A- PAL1I207R/FP59) in Acute... حسب Farhat, Mirna

"…Both variants proved to be highly potent against tumors while having an enhanced selectivity and as such paved the way to create a modified intermolecularly complementing (IMC), PAU2R200A-PAL1I207R, version of PrAg that requires activation by both uPA/uPAR and MMPs proteases, simultaneously. …"
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Methylation at global LINE-1 repeats in human blood are affected by gender but not by age or natural hormone cycles حسب El Maarri, Osman

"…Our results show that no significant association with age was observed. However, the previously reported increase of LINE-1 methylation in males was reconfirmed. …"
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Long Term HbA1c Prediction Using Multi-Stage CGM Data Analysis حسب Md Shafiqul Islam (7010348)

"…Having an elevated HbA1c level significantly increases the risk of developing diabetes-related health complications. …"

Pregnant Women's experiences with intimate partner violence one year after the COVID‐19 pandemic in Jordan حسب Sanaa Abujilban (12106945)

"…There were statistically significant (<i>p </i>≤ 0.05) higher mean DVQST scores for control IPV and psychological IPV during the pandemic (control IPV mean = 9.78, psychological mean = 7.03) versus before the pandemic (control IPV mean = 8.95, psychological mean = 6.62). …"

PD-L1 Expression in Human Breast Cancer Stem Cells Is Epigenetically Regulated through Posttranslational Histone Modifications حسب Pramod Darvin (153341)

"…Understanding the mechanisms behind this PD-L1 overexpression in cancer stem cells is critical for developing more effective strategies for preventing immune evasion and increasing the efficacy of anti-PD-1/PD-L1 therapy. …"

Akkermansia, a Possible Microbial Marker for Poor Glycemic Control in Qataris Children Consuming Arabic Diet—A Pilot Study on Pediatric T1DM in Qatar حسب Arun Prasath Lakshmanan (16444663)

"…The results have revealed that the subjects who had undergone CSII therapy had increased microbial diversity and genus <i>Akkermansia</i> was significantly enriched in the subjects without CSII therapy. …"

Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex حسب Wesam S. Ahmed (10170053)

"…In this regard, the recent SARS-CoV-2 alpha, beta, and gamma variants (B.1.1.7, B.1.351, and P.1 lineages, respectively) are of great significance in that they contain several mutations that increase their transmission rates as evident from clinical reports. …"